A5018110872- Immunotherapy and Immune Responses
- Toxin Mechanisms and Immunotoxins
- Cell death mechanisms and regulation
- Cancer Cells and Metastasis
- Microbial Natural Products and Biosynthesis
- Bacteriophages and microbial interactions
- Microbial Metabolism and Applications
- RNA Interference and Gene Delivery
- Peptidase Inhibition and Analysis
- Lung Cancer Research Studies
- Cancer Research and Treatments
- Cancer Mechanisms and Therapy
- Chemokine receptors and signaling
- Genomics and Phylogenetic Studies
Fundación Josep Carreras Contra la Leucemia
2021-2022
Hospital de Sant Pau
2021-2022
Josep Carreras Leukaemia Research Institute
2022
Universidad de Oviedo
2021
Therapy resistance, which leads to the development of loco-regional relapses and distant metastases after treatment, constitutes one major problems that head neck squamous cell carcinoma (HNSCC) patients currently face. Thus, novel therapeutic strategies are urgently needed. Targeted drug delivery chemokine receptor 4 (CXCR4) represents a promising approach for HNSCC management. In this context, we have developed self-assembling protein nanotoxins T22-PE24-H6 T22-DITOX-H6, incorporate...
Colorectal cancer (CRC) remains the third cause of cancer-related mortality in Western countries, metastases are main death. CRC treatment limited by systemic toxicity and chemotherapy resistance. Therefore, nanoparticle-mediated delivery cytotoxic agents selectively to cells represents an efficient strategy increase therapeutic index overcome drug We have developed T22-PE24-H6 protein-only nanoparticle that incorporates exotoxin A from Pseudomonas aeruginosa target because its multivalent...
Loco-regional recurrences and distant metastases represent the main cause of head neck squamous cell carcinoma (HNSCC) mortality. The overexpression chemokine receptor 4 (CXCR4) in HNSCC primary tumors associates with higher risk developing loco-regional metastases, thus making CXCR4 an ideal entry pathway for targeted drug delivery. In this context, our group has generated self-assembling protein nanocarrier T22-GFP-H6, displaying multiple T22 peptidic ligands that specifically target...
Genome mining has proven its usefulness in the search for novel bioactive compounds produced by microorganisms, and halogenases comprise an interesting starting point. In this work, we have identified a new halogenase coding gene that led to discovery of lipopetide nonribosomal peptide synthetase/polyketide synthase (NRPS/PKS)-derived natural products, colibrimycins, Streptomyces sp. strain CS147, isolated from Attini ant niche.
Advanced endometrial cancer (EC) lacks therapy, thus, there is a need for novel treatment targets. CXCR4 overexpression associated with poor prognosis in several cancers, whereas its inhibition prevents metastases. We assessed expression EC women by using IHC. Orthotopic models were generated transendometrial implantation of CXCR4-transduced cells. After vitro evaluation the CXCR4-targeted T22-GFP-H6 nanocarrier, subcutaneous used to study uptake tumor and normal organs. Of women, 91%...
Loco-regional recurrences and metastasis represent the leading causes of death in head neck squamous cell carcinoma (HNSCC) patients, highlighting need for novel therapies. Chemokine receptor 4 (CXCR4) has been related to loco-regional distant recurrence worse patient prognosis. In this regard, we developed a protein nanoparticle, T22-DITOX-H6, aiming selectively deliver diphtheria toxin cytotoxic domain CXCR4+ HNSCC cells. The antimetastatic effect T22-DITOX-H6 was evaluated vivo an...