A5052140994- Bone health and osteoporosis research
- Vitamin D Research Studies
- Bone health and treatments
- Bone and Joint Diseases
- Nutrition and Health in Aging
- Pituitary Gland Disorders and Treatments
- Diabetes and associated disorders
- Bone Metabolism and Diseases
- Cardiovascular Function and Risk Factors
- Diabetes Management and Research
- Advanced Glycation End Products research
- Vitamin C and Antioxidants Research
- Obesity, Physical Activity, Diet
- Childhood Cancer Survivors' Quality of Life
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adrenal and Paraganglionic Tumors
- Hip and Femur Fractures
- Diet and metabolism studies
- Parathyroid Disorders and Treatments
- Connective tissue disorders research
- Adolescent and Pediatric Healthcare
- Metabolism, Diabetes, and Cancer
- Pharmaceutical studies and practices
- Diabetes Treatment and Management
- Adipose Tissue and Metabolism
Massachusetts General Hospital
2022-2025
The University of Texas Southwestern Medical Center
2023-2025
Harvard University
2022-2024
SUNY Upstate Medical University
2014-2024
Brock University
2024
Winthrop-University Hospital
2013-2018
Diabetes Australia
2016
State University of New York
2016
AstraZeneca (Brazil)
2014
Sanofi (France)
2014
African Americans have a lower total serum 25-hydroxyvitamin D [25(OH)D] but superior bone health. This has been referred to as paradox. A recent publication found that free 25(OH)D is the same in black and white individuals. However, study was criticized because an indirect method used measure 25(OH)D. direct recently developed.We hypothesized although Americans, measured directly would not differ between races.White healthy postmenopausal women were matched for age body mass index. Serum...
Abstract Context Increased bone fragility and reduced energy absorption to fracture associated with type 2 diabetes (T2D) cannot be explained by mineral density alone. This study, for the first time, reports on alterations in tissue’s material properties obtained from individuals known status. Objective To investigate role of T2D altering biomechanical, microstructural, compositional fracture. Methods Femoral head tissue specimens were collected patients who underwent replacement surgery hip...
In Brief Older adults with type 1 diabetes are at high risk for severe hypoglycemia and may have serious comorbid conditions. Problems cognition, mobility, dexterity, vision, hearing, depression, chronic pain interfere the ability to follow complex insulin regimens. With development of geriatric syndromes, unpredictable eating, frailty, treatment regimens must be modified goal minimizing hyperglycemia maximizing quality life.
Abstract Purpose Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome of abnormal phosphate and vitamin D metabolism caused by typically small endocrine tumors that secrete fibroblast growth factor 23 (FGF23). TIO characterized clinically progressive musculoskeletal pain, fatigue, proximal muscle weakness, multiple fractures, leading to long-term disability. Misdiagnosis delayed diagnosis are common because the nonspecific symptoms, several years may elapse before patients...
Abstract Context Trabecular bone score (TBS), a gray-level texture index derived from lumbar spine (LS) dual-energy x-ray absorptiometry (DXA) scans, is decreased in patients with diabetes and associated increased fracture risk, independent of areal mineral density (aBMD), but potentially influenced by abdominal fat tissue. Objective Evaluate effect romosozumab (210 mg monthly) for 12 months followed alendronate (70 weekly) 24 vs alone 36 on LS aBMD TBS women type 2 (T2D) enrolled the ARCH...
It has been proposed that serum free 25-hydroxyvitamin D [25(OH)D] may better reflect vitamin action than total 25(OH)D. An ELISA for 25(OH)D recently become available, permitting direct assay.To determine whether provides additional information in relation to calcium absorption and other biomarkers of compared 25(OH)D.Ambulatory research setting a teaching hospital.Serum measured previously performed study varied doses D3 (placebo 800, 2000, 4000 IU) on absorption, PTH, procollagen type 1...
ABSTRACT Type 2 diabetes mellitus (T2DM) increases fracture risk despite normal or increased BMD. Abaloparatide reduces in patients with postmenopausal osteoporosis (PMO); however, its efficacy women T2DM is unknown. This post hoc analysis evaluated the and safety of abaloparatide T2DM. The included from A baloparatide C omparator T rial I n V ertebral E ndpoints (ACTIVE), a phase 3, double‐blind, randomized, placebo‐ active‐controlled trial. In ACTIVE, participants were randomized 1:1:1 to...
Bone health is influenced by the intake of both calcium and vitamin D. Our objective was to evaluate influence D supplementation on PTH bone turnover. At an ambulatory research center, 159 postmenopausal healthy white women participated in this double-blind, placebo-controlled parallel, longitudinal factorial study that 6 months duration. Subjects were randomly allocated 4 groups: 1) double placebo, 2) (1200 mg daily) plus 3) D3 (100 μg) 4) calcium. Serum urine collected fasting 2 hours...
OBJECTIVES To examine the effect of 25‐hydroxyvitamin D (25(OH)D) levels recommended by Endocrine Society guidelines (>30 ng/mL) on cognition in healthy older African‐American women over 3 years. DESIGN Randomized, double‐blind, placebo‐controlled clinical trial. SETTING Bone Mineral Research Center at New York University Winthrop Hospital. PARTICIPANTS Healthy postmenopausal African American aged 65 and (N=260; mean age 68.2 ± 4.9; 46% college education or higher). INTERVENTION Half were...
ABSTRACT Accumulation of advanced glycation end-products (AGE) in bone alters collagen structure and function. Fluorescent AGEs are associated with fractures but less is known regarding non-fluorescent AGEs. We examined associations carboxy-methyl-lysine (CML), incident clinical prevalent vertebral by type 2 diabetes (T2D) status, the Health, Aging, Body Composition cohort older adults. Incident baseline were assessed. Cox regression was used to analyze between serum CML fracture incidence,...
Abstract Bone histomorphometric endpoints in transilial biopsies may be associated with an increased risk of atypical femoral fracture (AFF) patients osteoporosis who take antiresorptives, including bisphosphonates (BPs). One way to test this hypothesis is evaluate bone age-, gender-, and treatment time-matched either had AFF or did not have AFF. In study, we performed transiliac 52 White postmenopausal women (n = 20) without 32) AFFs, all whom been treated for continuously alendronate 4–17...
Heart failure is a prominent complication of type 2 diabetes mellitus (T2D). The goal this study was to provide longitudinal data on cardiac structure and function (and cross-sectional comparison normal-weight obese controls without T2D) in individuals followed from adolescence with youth-onset T2D.In the TODAY (Treatment Options for Type Diabetes Mellitus Adolescents Youth), echocardiograms were performed at years 4 5 9 10. Echocardiograms also obtained 8 control population age,...
X-linked hypophosphatemia (XLH) is an inherited skeletal disorder that can lead to lifelong deleterious musculoskeletal and functional consequences. Although often perceived as a childhood condition, children adults both experience the negative effects of XLH. Adolescents young (AYAs) benefit from effective health care transition (HCT) preparation support transfer pediatric- adult-focused care. Whereas timelines, milestones, educational tools exist for some chronic conditions, they do not...
Abstract Osteoporosis in men is an underappreciated public health issue, accounting for approximately 30% of the societal burden osteoporosis. Although prevalence osteoporosis lower, fracture-related morbidity and mortality rates exceed those women. Abaloparatide a synthetic, 34-amino acid peptide with homology to human parathyroid hormone-related protein (PTHrP), which favors bone formation by selective activation PTH receptor type 1. In Treatment Men With (ATOM; NCT03512262) trial, 228...
Abstract Abaloparatide treatment significantly increased bone mineral density (BMD) at the lumbar spine, total hip, and femoral neck compared with placebo in men osteoporosis phase 3 ATOM trial. The current study used 3D-DXA modeling to evaluate effects of abaloparatide on cortical trabecular compartments proximal femur participants. Proximal DXA images were retrospectively analyzed using (3D-Shaper software v2.12.0, 3D-Shaper Medical, Barcelona, Spain) changes parameters from baseline...