A5066604386- Pluripotent Stem Cells Research
- Cardiomyopathy and Myosin Studies
- Cellular Mechanics and Interactions
- Muscle Physiology and Disorders
- Tissue Engineering and Regenerative Medicine
- Congenital heart defects research
- Histone Deacetylase Inhibitors Research
- Signaling Pathways in Disease
- Bipolar Disorder and Treatment
- Neurogenetic and Muscular Disorders Research
- Viral Infections and Immunology Research
- Biochemical effects in animals
- Cancer-related gene regulation
- Phytochemicals and Antioxidant Activities
- Genomic variations and chromosomal abnormalities
- Sirtuins and Resveratrol in Medicine
- Pancreatic function and diabetes
- Calpain Protease Function and Regulation
- RNA Interference and Gene Delivery
- CRISPR and Genetic Engineering
- Diabetes Treatment and Management
- Diet, Metabolism, and Disease
- Pharmacological Effects and Toxicity Studies
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
Nirma University
2012-2023
Fulcrum Therapeutics (United States)
2023
University of Houston
2017-2020
National Institutes of Health
2020
Yale University
2020
Harvard University
2020
Rockefeller University
2020
We have evaluated the effect of buspirone (1.5 mg/kg/day, p.o.) type 1 diabetes induced cardiovascular complications by streptozotocin (STZ, 45 mg/kg, i.v.) in Wistar rats. Various biochemical, cardiovascular, and hemodynamic parameters were measured at end 8 weeks treatment. STZ produced significant hyperglycaemia, hypoinsulinemia, dyslipidemia, which was prevented increase serum creatinine, urea, lactate dehydrogenase, creatinine kinase, C-reactive protein levels treatment with reduction...
The regulatory paradigm in cardiac hypertrophy involves alterations gene expression that is mediated by chromatin remodeling. Various data suggest class I and II histone deacetylases (HDACs) play opposing roles the regulation of hypertrophic pathways. To address this, we tested effect magnesium valproate (MgV), an HDAC inhibitor with 5 times more potency on HDACs. Cardiac was induced partial abdominal aortic constriction Wistar rats, at end 6 weeks, evaluated hypertrophic, hemodynamic,...
Muscle wasting, or muscle atrophy, can occur with age, injury, and disease; it affects the quality of life complicates treatment. Insulin-like growth factor 1 (IGF1) is a key positive regulator mass. The IGF1/Igf1 gene encodes multiple protein isoforms that differ in tissue expression, potency, function, particularly cellular proliferation differentiation, as well systemic versus localized signaling. Genome engineering novel strategy for increasing expression has potential to recapitulate...
Animal models have a pivotal role in biomedical research and contribute significantly to the study of human disease. C.B‐17 SCID mice which are homozygous for prkdscid mutation BALB/c background, been used support cancer, diabetes, obesity, cardiovascular diseases many other areas. In current study, we report severe cardiac calcinosis male at 10 weeks age, particularly right ventricular myocardium. Dystrophic is characteristic certain inbred strains background exhibit more susceptibility. It...
Cardiovascular diseases are a leading cause of death and disability in diabetic patients. Recent studies suggest that switching gears towards survival longevity factors such as sirtuins induce protection against cardiovascular complications The present study investigated the effect SIRT1 activator II on myocardial injury high fat diet‐induced type 2 mice. Adult C57BL/6J mice (n=16/group) were fed normal chow diet (ND‐10 Kcal % fat) or high‐fat (HFD‐60 for 6 months. Body weights blood glucose...
Abstract Inbred mouse strains are the most widely used mammalian model organism in biomedical research owing to ease of genetic manipulation and short lifespan; however, each inbred strain possesses a unique repertoire deleterious homozygous alleles that can make specific more susceptible particular disease. In current study, we report dystrophic cardiac calcinosis ( DCC ) C.B‐17 SCID male mice at 10 weeks age with no significant change function. Acquisition was characterized by myocardial...
Heart Failure (HF) accounts for 5.7 million deaths annually, which often are the result of acute or chronic ischemic injury due to myocardial infarction (MI). MI is associated with cardiomyocyte death succeeded by scar tissue formation. This serves as a mechanical barrier and prevents normal electrical conductivity through ventricles, thus contributing development arrhythmias. Various stem cell therapies cardiac repair directed towards replacing injured myocardium healthy cardiomyocytes....
Heart failure (HF) is a chronic condition where the heart loses its ability to efficiently pump blood other organs in body. Currently, there no cure for HF, than transplant, which may not be available most patients. Other treatments HF focus on reducing symptoms, but do properly address loss of cardiac tissue and scar formation commonly observed this condition. We believe that novel therapeutic approach can achieved through direct administration electrical conducting cells failing hearts....