A5055343363- Linguistic research and analysis
- Linguistic Education and Pedagogy
- Trypanosoma species research and implications
- Second Language Learning and Teaching
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Research on Leishmaniasis Studies
- Ion Channels and Receptors
- Ion channel regulation and function
- Connexins and lens biology
- Gender Studies in Language
- Bioactive Compounds and Antitumor Agents
- Palliative Care and End-of-Life Issues
- Social and Demographic Issues in Germany
- Family Support in Illness
- Synthesis and Biological Evaluation
- Heat shock proteins research
- Malaria Research and Control
- Synthesis and Catalytic Reactions
- Ancient and Medieval Archaeology Studies
- Synthesis and biological activity
- HIV/AIDS drug development and treatment
- PARP inhibition in cancer therapy
- Peptidase Inhibition and Analysis
- German Literature and Culture Studies
Johannes Gutenberg University Mainz
2017-2022
Goethe University Frankfurt
2017-2020
University Medical Center of the Johannes Gutenberg University Mainz
2017-2019
University of Geneva
1990
Significance Poly(ADP-ribose) polymerase-1 (PARP-1) is a DNA repair protein and part of the genome maintenance network. On other hand, PARP-1 involved in pathophysiological processes such as inflammation. Chronic inflammation has emerged key event carcinogenesis, including formation colorectal cancer (CRC). Our data reveal that abundantly expressed human CRC, correlating with disease progression. Using transgenic mouse models, we show fosters inflammation-driven tumor growth stimulates...
Abstract TRPV4 is a cell surface-expressed calcium-permeable cation channel that mediates cell-specific effects on cellular morphology and function. Dominant missense mutations of cause distinct, tissue-specific diseases, but the pathogenic mechanisms are unknown. Mutations causing peripheral neuropathy localize to intracellular N-terminal domain whereas skeletal dysplasia in multiple domains. Using an unbiased screen, we identified cytoskeletal remodeling GTPase RhoA as interactor....
Rhodesain is a major cysteine protease of Trypanosoma brucei rhodesiense, pathogen causing Human African Trypanosomiasis, and validated drug target. Recently, we reported the development α-halovinylsulfones as new class covalent reversible inhibitors. Here, α-fluorovinylsulfones/-sulfonates were optimized for rhodesain based on molecular modeling approaches. 2d, most potent selective inhibitor in series, shows single-digit nanomolar affinity high selectivity toward mammalian cathepsins B L....
Lipoic acid (LA) is a redox-active disulphide compound, which functions as pivotal co-factor for mitochondrial oxidative decarboxylation. LA and chemical derivatives were shown to target mitochondria in cancer cells with altered energy metabolism, thereby inducing cell death. In this study, the impact of on tumor suppressor protein p53 was analyzed various colorectal (CRC) lines, focus mechanisms driving degradation. First, demonstrated trigger depletion both wildtype mutant all CRC tested...
The efficient production of many medicinally or synthetically important starting materials suffers from wasteful toxic precursors for the synthesis. In particular, aromatic non-protected primary amine function represents a versatile synthetic precursor, but its synthesis typically requires oxidizing agents and transition metal catalysts. twofold electrochemical amination activated benzene derivatives via Zincke intermediates provides an alternative sustainable strategy formation new C-N...
Abstract Trypanosomal and leishmanial infections claim tens of thousands lives each year. The metabolism these unicellular eukaryotic parasites differs from the human host their enzymes thus constitute promising drug targets. Tryparedoxin (Tpx) Trypanosoma brucei is essential oxidoreductase in parasite's hydroperoxide‐clearance cascade. In vitro vivo functional assays show that a small, selective inhibitor efficiently inhibits Tpx. With X‐ray crystallography, SAXS, analytical SEC, SEC‐MALS,...
Ubiquitin (Ub)-mediated regulation of plasmalemmal ion channel activity canonically occurs via stimulation endocytosis. Whether ubiquitination can modulate by alternative mechanisms remains unknown. Here, we show that the transient receptor potential vanilloid 4 (TRPV4) cation is multiubiquitinated within its cytosolic N-terminal and C-terminal intrinsically disordered regions (IDRs). Mutagenizing select lysine residues to block but not IDR resulted in a marked elevation TRPV4-mediated...
Abstract Jedes Jahr fordern durch Trypanosomen und Leishmanien verursachte Infektionen zehntausende Menschenleben. Der Metabolismus dieser einzelligen eukaryotischen Parasiten unterscheidet sich von dem des menschlichen Wirts. Daher stellen die parasitären Enzyme vielversprechende Angriffspunkte für Arzneistoffe dar. Tryparedoxin (Tpx) aus Trypanosoma brucei ist eine essentielle Oxidoreduktase in der Detoxifizierungskaskade Hydroperoxide. Funktionale In‐vitro‐ In‐vivo‐Experimente zeigen,...
Prenant comme point de depart les resultats obtenus dans recherches sur l'acquisition en langue seconde, l'A. reflechit cet article leur impact pour l'enseignement futur la grammaire et des changements a adopter. S'il est vrai que l'apprentissage guide seconde se deroule meme facon naturelle du langage (en L1 ou L2), un cours qui veut efficient devra ainsi plier aux lois naturelle, ce signifie que: (1) progression grammaticale doit suivre sequences naturelles d'acquisition; (2) Les...
In bisherige Studien werden als Risikofaktoren im Bereich der familiären Betreuung mangelndes Selbstbewusstsein hinsichtlich persönlichen Kommunikationskompetenz Umgang mit Patienten und deren Angehörigen die Beziehung zu diesen genannt [1,2]. Während eines Interviews berichtete eine Pflegekraft bezüglich von Angehörigen: „Das ist bei Palliativpatienten mindestens genauso aufwendig wie Patient selbst.“ Eine andere erzählte: „Ich glaub wir sind auch oft ein Ventil für diese Schwierigkeiten....
Aufgrund des Anstiegs der Zahl Pflegebedürftigen [1] sowie Zunahme an krebsbedingten Erkrankungen [2] ist Ausbau Palliativversorgung notwendig [3]. Ziel vorliegenden Studie war es, die Lage aus Sicht Palliativpflegekräfte zu ermitteln.