A5029301178- Aquaculture Nutrition and Growth
- Reproductive biology and impacts on aquatic species
- Epigenetics and DNA Methylation
- Aquaculture disease management and microbiota
- Birth, Development, and Health
- Fish Ecology and Management Studies
- Selenium in Biological Systems
- RNA modifications and cancer
- Physiological and biochemical adaptations
- Peroxisome Proliferator-Activated Receptors
- Effects and risks of endocrine disrupting chemicals
- Animal Genetics and Reproduction
- Marine Bivalve and Aquaculture Studies
- Fatty Acid Research and Health
- Toxic Organic Pollutants Impact
- Ocean Acidification Effects and Responses
- Mercury impact and mitigation studies
- Folate and B Vitamins Research
- Pregnancy and preeclampsia studies
- Child Nutrition and Water Access
- Environmental Toxicology and Ecotoxicology
- Heavy Metal Exposure and Toxicity
- Biocrusts and Microbial Ecology
- Molecular Biology Techniques and Applications
- Marine Sponges and Natural Products
Norwegian Institute of Marine Research
2018-2025
New York University Press
2022
Cambridge University Press
2022
National Institute of Nutrition
2010-2014
University of Bergen
2009-2010
Abstract Methylation of cytosines is a prototypic epigenetic modification the DNA. It has been implicated in various regulatory mechanisms across animal kingdom and particularly vertebrates. We mapped DNA methylation 580 species (535 vertebrates, 45 invertebrates), resulting 2443 genome-scale profiles multiple organs. Bioinformatic analysis this large dataset quantified association with underlying genomic sequence throughout vertebrate evolution. observed broadly conserved link two major...
Endocrine-disrupting contaminants have been associated with aberrant changes in epigenetic pathways animals. In this study, zebrafish embryos were exposed bisphenol A (BPA) to search for associations between behavior and mechanisms fish. For concentration-dependent responses, a range of BPA concentrations (0.1 nM 30 μM). Embryos analyzed locomotor activity at 3-, 4-, 5-days post fertilization (dpf) response changing light conditions. Based on effects gene expression, 10 μM [from 24 96 hours...
Abstract Micronutrient status of parents can affect long term health their progeny. Around 2 billion humans are affected by chronic micronutrient deficiency. In this study we use zebrafish as a model system to examine morphological, molecular and epigenetic changes in mature offspring that experienced one-carbon (1-C) Zebrafish were fed diet sufficient, or marginally deficient 1-C nutrients (folate, vitamin B12, B6, methionine, choline), then mated. Offspring livers underwent histological...
Micronutrients (vitamins and minerals) have been less well studied compared to macronutrients (fats, proteins, carbohydrates) although they play important roles in growth, metabolism, maintenance of tissues. Hence, there is growing interest understand the influence micronutrients across various aspects nutritional research. In last two decades, aquaculture feeds shifted containing more plant-based materials meet increasing demand maintain sustainability industry. A recent whole life cycle...
Supplementation of one-carbon (1C) metabolism micronutrients, which include B-vitamins and methionine, is essential for the healthy growth development Atlantic salmon (
In spite of the high abundance and species diversity diatoms, only a few bioactive compounds from them have been described. The present study reveals number mammalian cell death inducing substances in biofilm-associated diatoms sampled intertidal zone. Extracts genera Melosira, Amphora, Phaeodactylum Nitzschia were all found to induce leukemia death, with either classical apoptotic or autophagic features. Several extracts also contained inhibitors thrombin-induced blood platelet activation....
Abstract World Health Organization is concerned for parental vitamin deficiency and its effect on offspring health. This study examines the of a marginally dietary-induced one carbon (1-C) micronutrient embryonic gene expression using zebrafish. Metabolic profiling revealed reduced 1-C cycle efficiency in F 0 generation. Parental fecundity total 364 genes were differentially expressed 1 embryos. The upregulated (53%) deficient group enriched biological processes such as immune response blood...
To ensure sustainability of aquaculture, plant-based ingredients are being used in feeds to replace marine-derived products. However, plants contain secondary metabolites which can affect food intake and nutrient utilisation fish. The application nutritional stimuli during early development induce long-term changes animal physiology. Recently, we successfully this approach improve the diets diploid triploid Atlantic salmon. In present study explored molecular mechanisms occurring liver...
Abstract Although early embryonic protein production relies exclusively on maternal molecules such as messenger RNAs (mRNAs) incorporated into ovarian follicles, knowledge about any thermally induced, intergenerational effects is scarce in ectotherms. Here, we investigated how elevated temperatures (9°–12°C vs. 6°C) during oogenesis influenced the next generation by targeting mRNAs Atlantic cod (Gadus morhua) embryos, view of up- and down-regulated genes follicles pre-spawning adults....
Manipulating spawning seasons of Atlantic salmon ( Salmo salar ) is a common practice to facilitate year-round harvesting in aquaculture. This process involves adjusting water temperature and light regime control female broodstock maturation. However, recent studies have indicated that altered can significantly affect the nutritional status growth performance offspring. Therefore, gaining deeper understanding biological regulations influenced by these alterations crucial enhance fish over...
This study explores the effect of high dietary arachidonic acid (ARA) levels (high ARA) compared with low ARA (control) on general metabolism using zebrafish as model organism. The fatty composition today's 'modern diet' tends towards higher n-6 PUFA in relation to n-3 PUFA. Low n-3:n-6 ratio is a health concern, give rise eicosanoids and PG, which are traditionally considered pro-inflammatory, especially when derived from ARA. Juvenile fed high-ARA diet for 17 d had lower whole-body low-ARA...
With regard to predicted oceanic warming, we studied the effects of heat stress on redox system during embryonic development Atlantic cod (Gadus morhua), with emphasis glutathione balance, activities key antioxidant enzymes, and their mRNA levels. The embryos were incubated at optimal temperature for (6 °C) or slightly above threshold (10 °C). regulation all redox-related parameters measured optimum was highly dynamic complex, indicating importance both maternal zygotic contributions...
The reduction potential of a cell is related to its fate. Proliferating cells are more reduced than those that differentiating, whereas apoptotic generally the most oxidized. Glutathione considered important cellular redox buffer and average (Eh) or organism can be calculated from concentrations glutathione (GSH) disulfide (GSSG). In this study, triplicate groups cod larvae at various stages development (3 63 days post-hatch; dph) were sampled for analyses GSSG/2GSH concentrations, together...
Diet has been shown to influence epigenetic key players, such as DNA methylation, which can regulate the gene expression potential in both parents and offspring. Diets enriched omega-6 deficient omega-3 PUFAs (low dietary omega-3/omega-6 PUFA ratio), have associated with promotion of pathogenesis diseases humans other mammals. In this study, we investigated impact increased intake arachidonic acid (ARA), a physiologically important PUFA, on 2 generations zebrafish. Parental fish were fed...
Feeding plant-based diet through smoltification of Atlantic salmon requires verification the optimal level 1C nutrients. Here, we fed diets containing three different surplus amounts nutrients; methionine, cobalamin (vitamin B12), pyridoxine B6) and folic acid during 6 weeks in fresh water, smoltification, followed by 3 months on-growing period salt water. The were to fish dispersed triplicate tanks throughout experiment. Mean start body weight was 32 g. Dietary methionine levels 6.7, 9.2...
Selenium is an essential micronutrient and its metabolism closely linked to the methionine cycle transsulfuration pathway. The present study evaluated effect of two different selenium supplements in diet rainbow trout (Onchorhynchus mykiss) broodstock on one-carbon hepatic DNA methylation pattern progeny. Offspring three parental groups trout, fed either a control (NC, basal Se level: 0.3 mg/kg) or supplemented with sodium selenite (SS, 0.8 mg Se/kg) hydroxy-selenomethionine (SO, 0.7 Se/kg),...
DNA methylation has an important role in intergenerational inheritance. An increasing number of studies have reported evidence germline inheritance induced by nutritional signals mammals. Vitamins and minerals as micronutrients contribute to growth performance vertebrates, including Atlantic salmon (Salmo salar), also a epigenetics environmental factors that alter status. It is understand whether the paternal diet can influence offspring through alterations signatures male germ cells.Here,...