The WHO 2021 data estimate that 2 million lives and 53 disability-adjusted life-years were lost in 2019 due to exposures selected chemicals. It is important know the pattern outcome of acute poisoning cases for proper planning, prevention management. Knowing will also help designing training modules primary care physicians make them aware about newer poisons their Awareness regarding consumed necessary early identification, initial management timely referral higher centres by physicians....

Introduction: Psychiatric disorders, especially anxiety and depression have been reported to an increased prevalence in chronic obstructive pulmonary disease (COPD) patients, but there is a paucity of data from India. Aims Objectives: Aim our study the frequency psychiatric comorbidities COPD patients their correlation with severity COPD, as per global initiative for lung guidelines. Materials Methods: This was conducted outpatient department tertiary care hospital (King George's Medical...

This cross-sectional study was carried out to assess drug prescribing pattern at a tertiary care teaching medical institute. One thousand prescriptions were randomly collected and analyzed using the world health organization indicators. The average number of drugs per prescription 2.91. percentage prescribed by generic name, from essential list (National) as fixed dose combinations (FDCs) 10.05%, 22.57%, 49.22%, respectively. total encounters with antibiotics, injectables, FDCs 19.70%,...

Background The rising prevalence of type 2 diabetes mellitus (T2DM) in the elderly is associated with mental health disorders like cognitive impairment and depression due to hyperglycemia inflammation. present study aims estimate its association clinical, biochemical, psychosocial factors identify high-risk subjects. Methods A cross-sectional was conducted at a tertiary care teaching hospital enrolled 99 patients T2DM, aged equal or more than 60 years from North India. Cognitive function...

Background Type 2 diabetes mellitus (T2DM) and aging are associated with inflammation. Our study investigates the diagnostic accuracy of pro- anti-inflammatory biomarkers in predicting T2DM geriatric population relation these clinical biochemical parameters. Methods This case-control included age-gender matched, 100 treatment-naïve cases, healthy controls. Clinical, biochemical, anthropometric parameters were comprehensively profiled. The quantified by enzyme-linked immunosorbent assay...

Introduction About one-half of patients who have essential hypertension obstructive sleep apnea (OSA), and about hypertension. OSA can cause even resistant if left untreated. These two entities often co-exist are seen as a continuum the same process. Eighty percent to 90% cases undiagnosed mostly because lack awareness. Material methods This was cross-sectional study done over period one year in tertiary care hospital. After taking informed consent, 179 hypertensive >18 years were...

Organophosphorous (OP) poisoning is one of the most common poisonings seen in India. OP compounds act through inhibition enzyme acetylcholinesterase and estimation pseudocholinesterase (PCE) activity strengthens diagnosis clinically uncertain cases poisoning. The role pralidoxime (PAM) therapy has been controversial.This study was aimed to determine prognostic significance PCE also assess PAM poisoning.Patients suspected age >12 years admitted emergency unit at a tertiary healthcare center...

Hair dye containing paraphenylenediamine (PPD) is widely used in India because of its free availability and low cost. PPD produces local as well systemic toxic effects when applied topically and/or ingested. It highly taken by mouth the outcome depends mainly on dose taken. Important clinical manifestations are angioedema leading to dysphasia respiratory distress, rhabdomyolysis, intravascular hemolysis, acute renal failure hepatic necrosis. Myocarditis or fatal arrhythmia may also occur...

Introduction: Obstructive sleep apnea (OSA) and hypothyroidism are closely linked as has been shown to lead the development of OSA through multiple mechanisms. With changing lifestyle patterns worldwide increased prevalence obesity, burden substantially increased. The association with is essential establish. If identified early, treatment associated can be done timely minimize potential harmful complications on all aspects patient's health. Aims: This study was find out in patients. Setting...

Thyroid dysfunction can cause inspiratory and expiratory muscle weakness in patients with or without chronic obstructive pulmonary disease (COPD) COPD results increased frequency of exacerbation thus lead to poor quality life. It may further increase cardiovascular risk thereby increasing mortality.

Background:: The plasma virome represents the overall composition of viral sequences present in it. Alteration has been reported treatment naïve and immunocompromised (CD4 count < 200) people with HIV (PWH). However, effect ART on PWH preserved CD4 counts is poorly understood. Objective:: We aimed to assess alterations comparison HIV-negative uninfected controls further investigate possible associations viruses inflammation immune dysfunction, namely, immunosenescence exhaustion....

Snake bite is an important cause of mortality and morbidity in India with estimated 35 000–50 000 fatal bites occurring annually. Neurological deficits following vasculotoxic snake are either due to intracranial haemorrhage or subarachnoid bleed as a result consumption coagulopathy. However, ischaemic strokes acute disseminated encephalomyelitis have been reported occasionally. We hereby report case leading leucoencephalopathy.

Introduction: Hansen's disease (leprosy) most commonly presents with cutaneous and nerve involvement. Rheumatological manifestations occur but are often under-recognized. Physicians rheumatologists alike perplexed the rheumatological manifestations, given that these may precede diagnosis of leprosy or suggest another disease, in addition to leprosy. We present our experience patients presenting manifestations. Methods: This was a retrospective study carried out Departments Rheumatology...

Background: Homocysteine (HCY) interferes with collagen cross-linking in bones and stimulates osteoclast activity. The activated osteoclasts secrete cathepsin K (CathK), a cysteine protease, eminent quantity during bone resorption. Hyperhomocysteinemia may effect mineral density (BMD) through CathK. We, therefore, examined the relation between HCY BMD along CathK, 25-hydroxyvit-D (25[OH]D), intact parathyroid hormone (iPTH), Vitamin B12. Materials Methods: We recruited total of 93...

Kerosene poisoning is a common in India especially childhood, and clinical spectrum can range from meager chemical pneumonitis to grave complications such as hypoxia, pneumothorax, pneumomediastinum, emphysema. Pyopneumothorax that may require aggressive management the form of thoracotomy has not been reported literature. We hereby report 22-year young female who had developed series respiratory including pyopneumothorax following ingestion kerosene with suicidal intent was treated successfully.

Introduction: Metabolic syndrome (MetS) and hypothyroidism are well-established forerunners of atherogenic cardiovascular disease (CVD). It is possible that patients suffering from both these entities may have a compounded risk. This study aimed at determining the prevalence in MetS. Materials Methods: cross-sectional was conducted September 2017 to August 2018 department medicine tertiary care hospital Northern India. Ethical approval obtained institutional ethical committee. The subjects...

Carotid artery intima media thickness reflects the ongoing process of atherosclerosis in body. The pathologic occurring obese patients vascular system is which an important cause ischemic stroke. Body mass index indirect measure obesity general population.The study was to assess role carotid as a marker and its relation with body stroke patients.Body all calculated by using formula kilograms divided square height meters. were classified four groups according Indian standards. sonography done...

Context: Glycated hemoglobin A1c(HbA1c) indicates long-term uncontrolled hyperglycemia in the body, which diabetic patients leads to various vascular complications as a part of generalized atherosclerosis culminating ultimately into ischemic stroke. Aims: Study aims show association between marker HbA1c and (Carotid intima media thickness [CIMT] carotid plaque) stroke patients. Subjects Methods: Carotid sonography using high resolution 7.5 MHz technique was done each patient find occurrence...

Infective endocarditis is the most common and dangerous form of endovascular infection. Fungal especially native valve rare with Candida albicans being causative organism in one-fourth such cases. Diagnosis cases further complicated if blood cultures are sterile, vegetations not initially seen on echocardiogram patient presents non-specific symptoms. We hereby report a fungal endocarditis, treated successfully voriconazole.