A5030989967- Tuberculosis Research and Epidemiology
- vaccines and immunoinformatics approaches
- Cancer, Lipids, and Metabolism
- Mycobacterium research and diagnosis
- Peptidase Inhibition and Analysis
- Infectious Diseases and Tuberculosis
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Monoclonal and Polyclonal Antibodies Research
- Advanced Chemical Sensor Technologies
- Phytoplasmas and Hemiptera pathogens
- Biosimilars and Bioanalytical Methods
- Diagnosis and treatment of tuberculosis
- Health Systems, Economic Evaluations, Quality of Life
- Biosensors and Analytical Detection
- Lipoproteins and Cardiovascular Health
- Radiomics and Machine Learning in Medical Imaging
- Microbial Natural Products and Biosynthesis
- Toxin Mechanisms and Immunotoxins
- Analytical Chemistry and Chromatography
- HIV-related health complications and treatments
International Centre for Genetic Engineering and Biotechnology
2020-2025
University of Cape Town
2020-2025
University of Bern
2023
South African Medical Research Council
2020-2021
University of Khartoum
2013-2018
University of Garden City
2018
National Ribat University
2018
Background. Currently, mutations in rpoB, KatG, and rrs genes inhA promoter were considered to be involved conferring resistance rifampicin, isoniazid, streptomycin Mycobacterium tuberculosis (MTB). Objective. The aims of this study detect the prevalence first-line (TB) drug among a group previously treated newly detected TB patients, determine association between multidrug (MDR) demographic information (age sex), explain correlated with MDR tuberculosis, characterize MTB via 16S ribosomal...
Mycetoma is a distinct body tissue destructive and neglected tropical disease. It endemic in many subtropical countries. caused by bacterial infections (actinomycetoma) such as Streptomyces somaliensis Nocardiae or true fungi (eumycetoma) Madurella mycetomatis. To date, treatments fail to cure the infection available marketed drugs are expensive toxic upon prolonged usage. Moreover, no vaccine was prepared yet against mycetoma.The aim of this study predict effective epitope-based...
Current clinical diagnostics are based on biochemical, physics and microbiological methods. The electronic nose system used to detect chemical components or VOCs in urine sample is meant classify different so as be able diagnose diseases other elements accurately. This study from 13 patients Universiti Teknologi Malaysia (UTM) health centre for the analysis. Findings revealed that six tested abnormal with mucus while only one patient bacteria two healthy. test conducted using Cyranose 320...
Cryptococcus neoformans is the highest‐ranked fungal pathogen in Fungal Priority Pathogens List (FPPL) released by World Health Organization (WHO). In this study, through silico simulations, a multi‐epitope vaccine against was developed using mannoprotein antigen (MP88) as candidate. Following retrieval of MP88 protein sequences, these were used to predict antigenic B‐cell and T‐cell epitopes via bepipred tool artificial neural network, respectively. Conserved AYSTPA, AYSTPAS, PASSNCK,...
Introduction Statins, also known as 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors, are lipid-lowering agents that central in preventing or reducing the complications of atherosclerotic cardiovascular disease. Because statins have anti-inflammatory properties, there is considerable interest their therapeutic potential other chronic inflammatory conditions. We aim to identify statin with greatest ability reduce systemic inflammation, independent underlying disease...
Abstract Background Mycetoma is a distinct flesh eating and destructive neglected tropical disease. It endemic in many subtropical countries. caused by bacterial infections (actinomycetoma) such as Streptomyces somaliensis Nocardiae or true fungi (eumycetoma) Madurella mycetomatis. Until date, treatments fail to cure the infection available marketed drugs are expensive toxic upon prolonged usage. Moreover, no vaccine was prepared yet against mycetoma. The aim of this study predict effective...
The KatG gene of Mycobacterium Tuberculosis has been associated with isoniazid (INH) drug resistance. While considered as corner stone and main chemotherapy used throughout the world to manage tuberculosis, thus Progress in apprehension principle concepts resistance allowed molecular tests addition bioinformatics tool for detection drug-resistant tuberculosis be developed. In Consecutive isolates (n = 20) multidrug-resistant part katG was sequenced INH analysis. BLAST analysis all sequences...
<h3>Background</h3> Despite the availability of anti-TB treatment, successfully treated TB patients remain with persisting lung inflammation regardless HIV status. Lung has been linked robust or imbalanced host immune responses which exacerbate tissue necrosis. Soluble biomarkers have shown to correlate development at different stages treatment further affect sputum conversion in these patients. In our ongoing StatinTB trial (RIA2017T-2004; NCT04147286), we evaluate safety and efficacy 40 mg...
<h3>Background</h3> Morbidity and mortality rates after successful completion of a six-month course tuberculosis (TB) treatment remain elevated. Persistent lung inflammation (PLI) on 18F-FDG-PET/CT has been associated with TB relapse may also lead to post-TB disease (PTLD). <h3>Methods</h3> The ongoing EDCTP-funded StatinTB trial (RIA2017T-2004; NCT04147286) evaluates safety/efficacy 40 mg atorvastatin reduce PLI in HIV-/HIV+ adults measured by extended total follow-up 96 weeks (ExtendTB,...
<h3>Background</h3> Post-TB lung disease (PTLD) is a neglected chronic condition that occurs despite successful completion of TB treatment. Statins have broad-range immune-modulatory and anti-inflammatory properties with potential to reduce PTLD improve symptoms. In our ongoing StatinTB trial (RIA2017T-2004; NCT04147286), we evaluate safety efficacy 40 mg atorvastatin persistent inflammation (PLI) after treatment in HIV-/HIV+ adults measured by 18F-FDG-PET/CT. Here aim investigate the ex...