A5030949240- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cutaneous Melanoma Detection and Management
- CAR-T cell therapy research
- Immune cells in cancer
- Radiomics and Machine Learning in Medical Imaging
- Single-cell and spatial transcriptomics
- Ferroptosis and cancer prognosis
- Atherosclerosis and Cardiovascular Diseases
- Advanced Biosensing Techniques and Applications
- Gene expression and cancer classification
- Lymphoma Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Drug Transport and Resistance Mechanisms
- Sports Dynamics and Biomechanics
- Cancer Cells and Metastasis
- Urban Transport and Accessibility
- Medical Imaging Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Sports Performance and Training
- Virus-based gene therapy research
- Hepatitis B Virus Studies
- Sports Analytics and Performance
- Manufacturing Process and Optimization
- Allergic Rhinitis and Sensitization
Columbia University
2019-2023
Medical Research Institute of New Zealand
2022
Columbia College
2020
Royal College of Physicians
2020
New York Hospital Queens
2019
Columbia University Irving Medical Center
2019
NewYork–Presbyterian Hospital
2019
University of Otago
2019
Rhode Island Hospital
2016
Brown University
2016
Abstract Objective We aimed to describe the impact on single ED serving Dunedin, New Zealand, following introduction of an electric‐scooter (e‐scooter) sharing service. Methods A retrospective cohort study comparing number vehicle related injuries during identical 6‐week periods in 2018 and 2019 was performed. descriptive analysis subset e‐scooter presentations undertaken. Results total 172 228 injury were identified samples from 2019, respectively. During period zero identified. In there 56...
Cell culture (cc)-derived hepatitis B virus (HBV) can infect differentiated HepaRG cells, but efficient infection requires addition of polyethylene glycol (PEG) during inoculation. Identification sodium taurocholate cotransporting polypeptide (NTCP) as an HBV receptor enabled ccHBV NTCP reconstituted HepG2 although very little surface antigen (HBsAg) is produced. We found by patient serum-derived (sHBV), which required purification viral particles through ultracentrifugation or PEG...
Abstract Patients with resected stage II-III melanoma have approximately a 35% chance of death from their disease. A deeper understanding the tumor immune microenvironment (TIME) is required to stratify patients and identify factors leading therapy resistance. We previously identified that profile (MIP), an IFN-based gene signature, ratio CD8+ cytotoxic T lymphocytes (CTL) CD68+ macrophages both predict disease-specific survival (DSS). Here, we compared primary metastatic tumors found nuclei...
Abstract Purpose: Biomarkers are needed to stratify patients with stage II–III melanoma for clinical trials of adjuvant therapy because, while immunotherapy is protective, it also confers the risk severe toxicity. We previously defined and validated a 53-immune gene immune profile (MIP) predictive both distant metastatic recurrence disease-specific survival (DSS). Here, we test MIP on third independent population. Experimental Design: A retrospective cohort 78 primary was analyzed using...
Purpose Investigate the ability of 18 F-fluorothymidine (FLT) PET combined with CT at 6 weeks to predict treatment response 12 after pembrolizumab. Methods Five patients unresectable stage IV melanoma were included in this single-institution pilot study. Patients underwent FLT-PET/CT (baseline and weeks) weeks). assessed using Response Criteria Solid Tumors immune Evaluation Tumors, respectively. categorized as responders (complete response, partial response) nonresponders (stable disease,...
We previously isolated AF20, a murine monoclonal antibody that recognizes cell surface glycoprotein of approximately 90–110 kDa. The AF20 antigen is specifically expressed in human hepatoma and colon cancer lines, thus could serve as biomarker. To uncover the molecular identity antigen, combination ion-exchange chromatography, immunoprecipitation, SDS—polyacrylamide gel electrophoresis was employed to purify followed by trypsin digestion mass spectrometry. Surprisingly, three host proteins...
<p>Figure legends for supplementary figures.</p>
<p>MIP correlates with OS.</p>
<p>Heat map showing relative levels of mRNA expression for each gene, specifying the gene represented by row.</p>
<p>Melanoma Immune Profile (MIP) correlates with metastasis cohort including patients local recurrence only.</p>
<p>Patient characteristics in metastasis cohort.</p>
<div>AbstractPurpose:<p>Biomarkers are needed to stratify patients with stage II–III melanoma for clinical trials of adjuvant therapy because, while immunotherapy is protective, it also confers the risk severe toxicity. We previously defined and validated a 53-immune gene immune profile (MIP) predictive both distant metastatic recurrence disease-specific survival (DSS). Here, we test MIP on third independent population.</p>Experimental Design:<p>A retrospective cohort...
<p>Comparison of patient demographics in validation cohort to original publication discovery and test cohorts.</p>
<div>AbstractPurpose:<p>Biomarkers are needed to stratify patients with stage II–III melanoma for clinical trials of adjuvant therapy because, while immunotherapy is protective, it also confers the risk severe toxicity. We previously defined and validated a 53-immune gene immune profile (MIP) predictive both distant metastatic recurrence disease-specific survival (DSS). Here, we test MIP on third independent population.</p>Experimental Design:<p>A retrospective cohort...
<p>MIP correlates with OS.</p>
<p>Comparison of patient demographics in validation cohort to original publication discovery and test cohorts.</p>
<p>Patient characteristics in metastasis cohort.</p>
<p>Melanoma Immune Profile (MIP) correlates with metastasis cohort including patients local recurrence only.</p>
<p>Heat map showing relative levels of mRNA expression for each gene, specifying the gene represented by row.</p>
<p>Supplemental Figure Legends</p>
<p>CD8/CD68 ratio is predictive of recurrence. Receiver Operating Characteristic (ROC) curve analysis for visceral recurrence (n=52, AUC=0.684, p=0.0350 by Mann-Whitney U test).</p>