A5081830914- GDF15 and Related Biomarkers
- Nutrition and Health in Aging
- Macrophage Migration Inhibitory Factor
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Pregnancy and Medication Impact
Universidade Federal Fluminense
2021-2025
Growth differentiation factor-15 (GDF-15) is a cytokine upregulated in multiple pathological conditions where oxidative stress, endothelial dysfunction, tissue aging, and chronic inflammation are the hallmarks. GDF-15 has many sources of production, including cardiac vascular myocytes, cells, adipocytes macrophages response to metabolic oncogenic transformation burden proinflammatory cytokines or reactive oxygen species. Although main extracardiac tissues, it been shown be elevated...
Resumo Fundamento Há uma falha em se identificar pacientes com insuficiência cardíaca (IC) um risco aumentado de hospitalização e morte. O Fator Diferenciação Crescimento-15 (GDF-15), biomarcador associado inflamação estresse oxidativo, surge como candidato a doença renal cardiovascular. Valores baixos taxa filtração glomerular estimada (TFGe), Sódio Urinário (NaU), valores altos da relação albumina/creatinina urinária são marcadores renais já associados alto internação hospitalar...
Abstract Background There is a lack in identifying heart failure (HF) patients with an increased risk of hospitalization and death. Growth differentiation factor 15 (GDF-15), biomarker associated inflammation oxidative stress, emerges as candidate cardiovascular renal disease. The low estimated glomerular filter rate (eGFR), urinary sodium (UNa), the high ratio albumin to creatinine are markers already mortality. Objective To evaluate relationship between GDF-15 chronic HF. Method We...
Abstract Background Patients with heart failure (HF) often have altered renal function. Urinary sodium is a marker of diuretic resistance and associated worse prognosis in HF. Growth differentiation factor-15 (GDF-15) oxidative stress inflammation prognostic predictor Objectives We sought to assess the relationship GDF-15 function parameters urinary patients chronic Methods undertook cross-sectional study HF from specialized outpatient clinic. signs symptoms LVEF <50% were included....