A5005388955- Mast cells and histamine
- Asthma and respiratory diseases
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Food Allergy and Anaphylaxis Research
- Chemokine receptors and signaling
- Antimicrobial Peptides and Activities
- Urticaria and Related Conditions
- Cytokine Signaling Pathways and Interactions
- Allergic Rhinitis and Sensitization
- Liver Disease Diagnosis and Treatment
- Eosinophilic Esophagitis
- Liver physiology and pathology
- Immunotherapy and Immune Responses
- Liver Disease and Transplantation
Instituto Politécnico Nacional
2010-2016
Center for Research and Advanced Studies of the National Polytechnic Institute
2007-2016
Universidad Nacional Autónoma de México
2007-2015
Instituto Nacional de Cancerología
2015
Harvard University
2014
Boston Children's Hospital
2014
Instituto de Estudios Avanzados
2010
Abstract Mast cells produce proinflammatory cytokines in response to TLR4 ligands, but the signaling pathways involved are not fully described. In this study, participation of Src family kinase Fyn production TNF after stimulation with LPS was evaluated using bone marrow–derived mast from wild-type and Fyn-deficient mice. Fyn−/− showed higher LPS-induced secretion preformed de novo–synthesized TNF. both cell types, colocalized vesicle-associated membrane protein (VAMP)3-positive...
AII (angiotensin II) is a vasoactive peptide that plays an important role in the development of liver fibrosis mainly by regulating profibrotic cytokine expression such as TGF‐β (transforming growth factor‐β). Activated HSCs (hepatic stellate cells) are major cell type responsible for ECM (extracellular matrix) deposition during and also target actions. Here, we studied effect on mRNA levels isoforms primary cultures rat HSCs. Both quiescent activated were stimulated with different time...
Abstract Signaling through the high affinity receptor for IgE (FcεRI) on mast cells comprises an intricate network of protein‐protein modifications and interactions leading to cell degranulation, lipid‐derived mediator production cytokine release. Depending tissue where are activated, release can induce distinct allergy symptoms. FcεRI mainly couples at least two Src family kinases (Lyn Fyn), which responsible initiation signaling cascade. Distinct membrane bound adapters couple initial...
Abstract Signaling pathways leading to cytokine production after TLR-4 triggering in mast cells (MC) are not well described. In this work, the participation of Src family kinase Fyn on TNF stimulation with LPS was evaluated MCs from WT and Fyn-deficient mice. Fyn−/− showed higher LPS-induced secretion preformed de novo synthesized processes underlying that phenotype were investigated. both cell types, co-localized VAMP3-positive compartments. Although addition provoked coalescence VAMP3...