A5084730518- Venomous Animal Envenomation and Studies
- Rabies epidemiology and control
- Endometriosis Research and Treatment
- Bioactive Natural Diterpenoids Research
- Reproductive System and Pregnancy
- Ovarian function and disorders
- Cholinesterase and Neurodegenerative Diseases
- Diet, Metabolism, and Disease
- Studies on Chitinases and Chitosanases
- Uterine Myomas and Treatments
- Reproductive tract infections research
- Pelvic floor disorders treatments
- Ion channel regulation and function
- Ectopic Pregnancy Diagnosis and Management
- Reproductive Health and Technologies
- Neuroscience and Neuropharmacology Research
- Healthcare and Venom Research
- Liver Disease Diagnosis and Treatment
- Gynecological conditions and treatments
- Autophagy in Disease and Therapy
- Blood Coagulation and Thrombosis Mechanisms
- Eosinophilic Esophagitis
- Nicotinic Acetylcholine Receptors Study
- Toxin Mechanisms and Immunotoxins
Wannan Medical College
2025
Guangxi Medical University
2022-2024
First Affiliated Hospital of GuangXi Medical University
2022-2023
To investigate the antioxidative mechanism of snake venom-derived protein C activator (PCA) in mitigating vascular endothelial cell injury. Human umbilical vein cells (HUVECs) were cultured DMEM containing 1.0 g/L D-glucose and exposed to hypoxia (1% O2) for 6 h followed by reoxygenation 2 establish a model oxygen-glucose deprivation/reoxygenation (OGD/R). The was treated with μg/mL PCA alone or combination 2-ME2 (a HIF-1α inhibitor) DMOG stabilizer), intracellular production reactive oxygen...
Abstract Intrauterine adhesions (IUA) are a common gynecological problem. Stem cell therapy has been widely used in the treatment of IUA. However, due to complex and harsh microenvironment uterine cavity, effectiveness such is greatly inhibited. This study aimed investigate whether melatonin pretreatment enhances efficacy human umbilical cord mesenchymal stem cells (HucMSCs) IUA rats. First, we explored effect on biological activity HucMSCs vitro through macrophage co-culture system, Cell...
Naja atra bite is one of the most common severe snakebites in emergency departments. Unfortunately, pathophysiological changes caused by are unclear due to lack good animal models. In this study, an model Guangxi Bama miniature pigs was established intramuscular injection at 2 mg/kg venom, and serum metabolites were systematically analyzed using untargeted metabolomic targeted approaches. Untargeted analysis revealed that 5045 chromatographic peaks obtained ESI+ 3871 ESI-. Screening modes...
Background: Bungarus multicinctus is one of the most dangerous venomous snakes prone to cardiopulmonary damage with extremely high mortality. In our previous work, we found that glutamine (Gln) and synthetase (GS) in pig serum were significantly reduced after bite. present study, explore whether there a link between pathogenesis injury Gln metabolic changes induced by venom. We investigated effect supplementation on lung heart function snakebite. Methods: supplemented different...
α-conotoxin AuIB is the only one of 4/6 type α-conotoxins (α-CTxs) that inhibits γ-aminobutyric acid receptor B (GABABR)-coupled N-type calcium channel (CaV2.2). To improve its inhibitory activity, a series variants were synthesized and evaluated according to structure-activity relationships 4/7 α-CTxs targeting GABABR-coupled CaV2.2. Surprisingly, substitution Pro7 with Arg results in 2-3-fold increase inhibition CaV2.2 (IC50 0.74 nM); substitutions position 9-12 basic or hydrophobic amino...
Abstract Activation of hepatic stellate cells (HSCs) is the most important factor in fibrosis progression. Autophagy closely related to activation HSCs. Based on our previous works, this research tried explore anti-fibrotic mechanism combination therapy with Taurine, Epigallocatechin gallate（EGCG） and Genistein, referred as TEG, by monitored autophagy HSCs CCl4-induced liver rats. Transmission electron microscopy showed that there were many autophagosomes lysosomes fibrotic After TEG...