A5005973351- Analytical Chemistry and Chromatography
- Environmental Toxicology and Ecotoxicology
- Pharmaceutical and Antibiotic Environmental Impacts
- Advanced Chemical Sensor Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Forensic Toxicology and Drug Analysis
- Toxic Organic Pollutants Impact
- Psychedelics and Drug Studies
- Pesticide and Herbicide Environmental Studies
- Antibiotics Pharmacokinetics and Efficacy
- Electrochemical Analysis and Applications
- Photochromic and Fluorescence Chemistry
- Water Quality Monitoring and Analysis
- Chemical Reactions and Isotopes
- Neurotransmitter Receptor Influence on Behavior
- Metabolomics and Mass Spectrometry Studies
- Microplastics and Plastic Pollution
- Effects and risks of endocrine disrupting chemicals
- Various Chemistry Research Topics
University of Trás-os-Montes and Alto Douro
2022-2025
Cooperativa de Ensino Superior Politécnico e Universitário
2020-2025
Unidade em Ciências Biomoleculares Aplicadas
2024
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde
2020-2021
Abstract Chiral pharmaceuticals, racemic or enantiomerically pure forms and their metabolites, can reach aquatic ecosystems via wastewater effluents (inefficient treatment operations) by direct human disposal. They may negatively affect nontarget organisms even at low environmental concentrations. To make an accurate risk evaluation, the (eco)toxicity of both enantiomers needs to be assessed. Promethazine (PMZ) is a chiral antihistamine that has been detected in owing its high consumption....
MDMA (3,4-methylenedioxymethamphetamine) is a chiral psychoactive recreational drug sold in illicit markets as racemate. Studies on the impact of aquatic organisms are scarce. While enantioselectivity toxicity animals and humans has been reported, none reported organisms. This study aimed to investigate ecotoxicological effects its enantiomers Daphnia magna. For that, (enantiomeric purity > 97%) were separated by liquid chromatography using homemade semipreparative column. Daphnids...
Abstract Ketamine is a chiral drug used for various clinical purposes but often misused. It metabolized to norketamine, an active metabolite. Both substances have been detected in environmental matrices, studies about their enantioselective toxic effects are scarce. In the present study, enantiomers of ketamine and norketamine were separated by semipreparative liquid chromatography method, toxicity was investigated different aquatic organisms. The enantioseparation achieved using homemade...
Synthetic cathinones (SC) are drugs of abuse that have been reported in wastewaters and rivers raising concern about potential hazards to non-target organisms. In this work, 44 SC were selected for silico studies, a group five emerging was prioritized further vivo ecotoxicity studies: buphedrone (BPD), 3,4-dimethylmethcathinone (3,4-DMMC), butylone (BTL), 3-methylmethcathinone (3-MMC), 3,4-methylenedioxypyrovalerone (MDPV). short-term exposures performed with the protozoan
Amphetamine (AMP) is a chiral psychoactive substance that exhibits enantioselectivity in its pharmacological properties. It has been detected wastewaters and surface waters can occur as enantiomeric mixtures, but little known about environmental risk potential enantioselective toxicity to aquatic organisms. Our study aimed target AMP the freshwater invertebrate Daphnia magna. Daphnids were subchronically exposed racemate (rac-AMP: 0.1, 1.0, 10 µg/L) pure enantiomers, (R)-AMP (S)-AMP (0.1,...
Ketamine (K) and its main metabolite, norketamine (NK), are chiral compounds that have been found in effluents from wastewater treatment plants (WWTPs) aquatic environments. Little is known about their enantioselective biodegradation during sewage treatment; however, this information pivotal for risk assessment, the evaluation of WWTP performance epidemiological studies. The aim study was to investigate pattern enantiomers K by activated sludge (AS) a WWTP. For that, an liquid chromatography...
3,4-Methylenedioxypyrovalerone (MDPV) is an emerging, chiral, new psychoactive substance belonging to the synthetic cathinones group that has been frequently detected in wastewater effluents and aquatic environments. However, knowledge of its enantioselective occurrence toxicity toward organisms scarce. The aim this work was develop liquid chromatography (LC) method monitor enantiomers MDPV environmental ecotoxicological assays. For that, different chiral columns mobile phases both normal...
Results: Poisoning has been reported as cause of admission and death in Portuguese rescue centres both mammals birds [3,4].Strychnine, insecticides, anticoagulants rodenticides, molluscicides, heavy metals have all wildlife poisoning events Portugal.Clinical cases accidental intentional carnivorous prey (4,5).Iberian wolfs, Iberian lynxes, red foxes, vultures, kites, eagles rooks are among the most frequently species.Stomach contents, blood, urine, liver kidneys used samples to detect these...
e disponibilizadas em 1935, as sulfonamidas rapidamente foram associadas a curas "milagrosas" de várias doenças.