A5041284576- Attention Deficit Hyperactivity Disorder
- Neuroscience and Neuropharmacology Research
- Endoplasmic Reticulum Stress and Disease
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neural Engineering
- Tryptophan and brain disorders
- Adipose Tissue and Metabolism
- Functional Brain Connectivity Studies
- Diet and metabolism studies
- Autophagy in Disease and Therapy
- Occupational Health and Safety in Workplaces
- Alzheimer's disease research and treatments
- Photoreceptor and optogenetics research
- Pancreatic function and diabetes
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics and Neurodevelopmental Disorders
- Neurogenesis and neuroplasticity mechanisms
- Neurobiology and Insect Physiology Research
- Nuclear Receptors and Signaling
- RNA regulation and disease
- Olfactory and Sensory Function Studies
Allen Institute for Brain Science
2025
Johns Hopkins University
2025
Universidad de Santiago de Chile
2014-2024
Alteration in the buffering capacity of proteostasis network is an emerging feature Alzheimer's disease (AD), highlighting occurrence endoplasmic reticulum (ER) stress. The unfolded protein response (UPR) main adaptive pathway to cope with folding stress at ER. Inositol-requiring enzyme-1 (IRE1) operates as a central ER sensor, enabling establishment and repair programs through control expression transcription factor X-box binding 1 (XBP1). To artificially enforce UPR AD brain, we developed...
Aging compromises brain function leading to cognitive decline. A cyclic ketogenic diet (KD) improves memory in aged mice after long-term administration; however, short-term effects later life and the molecular mechanisms that govern such changes remain unclear. Here, we explore impact of a KD treatment starting at elderly stage on mice. Behavioral testing potentiation (LTP) recordings reveal working hippocampal LTP. Furthermore, synaptosome proteome fed evidence predominantly presynaptic...
In ADHD treatment, methylphenidate (MPH) is the most frequently used medication. The present work provides evidence that MPH restored behavioral impairments and neuroplasticity due to changes in AMPAR subunit composition distribution, as well maturation of dendritic spines, a prenatal nicotine exposure (PNE) mouse model. PNE animals controls were given single oral dose (1 mg/kg), their behavior was tested for attention, hyperactivity, working memory. Long-term potentiation (LTP) induced...
Methylphenidate (MPH) is widely used in the treatment of Attention Deficit Hyperactivity Disorder. Several lines evidence support that MPH can modulate learning and memory processes different ways including improvement impairment test performances. A relevant factor efficacy whether administration performed once or several times. In this study we demonstrate opposite effects on performance preadolescent rats Morris Water Maze test. Animals treated with a single dose (1 mg/kg) significantly...
Attention Deficit-Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder with high incidence in children and adolescents characterized by motor hyperactivity, impulsivity, inattention. MRI-based evidences support that neuroanatomical abnormalities as the volume reduction of neocortex hippocampus are shared several neuropsychiatric diseases schizophrenia, autism spectrum ADHD. In addition, it well documented abnormal development postnatal pruning dendritic spines neocortical neurons...
Two semisynthetic acetyl derivatives of the alkaloid sauroine from Huperzia saururus, monoacetyl sauroine, and diacetyl (DAS) were obtained their chemical structures analyzed by NMR. While is typical product acetylation, DAS an unexpected derivative related to keto-enol formation sauroine. Recordings field excitatory post-synaptic potentials CA1 region rat hippocampal slices showed that only acutely applied induced long-term potentiation (LTP) in a dose-dependent manner with EC50 1.15 ± 0.09...
<title>Abstract</title> <bold>Background.</bold>Attention Deficit-Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder with prevalence around 5% in children and adolescents 2.5% adults. Recent reports using GWAS approaches have identified several genetic risk loci for this disorder. However, the epigenetic influence of extrinsic factors during pregnancy or exposure to environmental childhood, on onset remains unclear. This question has been addressed mainly by analyzing fluid...
Abstract Alteration in the buffering capacity of proteostasis network is an emerging feature Alzheimer’s disease (AD), highlighting occurrence endoplasmic reticulum (ER) stress. The unfolded protein response (UPR) main adaptive pathway to cope with folding stress at ER. Inositol requiring enzyme-1 (IRE1) ER-located kinase and endoribonuclease that operates as a central ER sensor, enabling establishment repair programs through control expression transcription factor X-Box binding 1 (XBP1). A...
Summary Aging is a complex biological process that compromises brain function and neuronal network activity, leading to cognitive decline synaptic dysregulation. In recent years, cyclic Ketogenic Diet (KD) has emerged as potential treatment ameliorate by improving memory in aged mice after long-term administration. However, the molecular mechanisms govern such changes remains unclear. Additionally, whether short-term KD administration later life preserves not been addressed detail....