Abstract We studied the prevalence of habitual snoring and its associations with tonsillar size, allergic rhinitis, obesity, parental smoking, as well obstructive sleep apnea (OSAS) in a sample 1,142 children aged 6–13 years (mean, 7.25 ± 0.58) from seven randomly selected schools Hat yai, Southern Thailand. Eighty‐five (8.5%) were snorers; was same boys girls. Significant independent association present between rhinitis an odds ratio 5.27 (95% CI, 1.57–17.77). The significantly increased to...

We report the first establishment of in vitro cultivation and genotypic characterization Leishmania siamensis isolated from an autochthonous disseminated dermal visceral leishmaniasis a Thai acquired immunodeficiency syndrome (AIDS) patient. The molecular identification has shown that parasite was identical to L. , recently described species reported southern provinces Thailand. phylogenetic analysis confirmed as closely related zoonotic enrietti .

Head and neck cancers are prevalent in Thailand, particular the southern region of country. However, survival with a large data set has not been reported. The purpose present study was to evaluate figures prognostic factors cohort patients treated university hospital located south Thailand.Consecutive new cases primary carcinoma oral cavity, oropharyx, hypopharynx larynx, at Songklanagarind Hospital during 2002 2004, were analyzed. 5-year overall rates obtained by Kaplan-Meier method....

The 14-3-3 protein has been shown to be involved in the cancer process. However, there is no understanding of relationship between 14-3-3γ (14-3-3 gamma) expression and prognosis advanced non-small cell lung cancer. In this study, we therefore investigated association levels by immunohistochemistry clinicopathological features NSCLC patients. Survival curves were estimated using Kaplan-Meier method tested log-rank. Multivariate analysis was conducted with Cox's regression model determine...

Background. Breast cancer is the second most common cause of death in Thai women. Cancer registry data reveal a high prevalence late-stage disease at diagnosis. The factors resulting delay Thailand have not yet been investigated. Objectives. To determine extent of, and contributing to, breast care. Design. Women with who were first treated Songklanagarind Hospital between June 1994 1996 interviewed retrospective chart audits Measures. Dependent variables included patient (symptom recognition...

MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression at the post-transcriptional level. Since aberrant of miRNAs has been proposed as usage for blood-based biomarkers, hence reliable techniques miRNA isolation well stability in various stored conditions needs to be explored. This present study aimed investigate efficacy Trizol-based technique and serum cDNA derivatives. Total RNA, including miRNAs, was isolated from human a comparison efficiency Trizol®LS...

Background: Immunohistochemistry (IHC)-based protein markers representing molecular subtypes are of great value for routine use. This study aimed to evaluate the frequency distributions triple-negative breast cancer (TNBC) using IHC-based surrogate and examined their prognostic value. Methods: Patients with TNBC treated at a university hospital in Southern Thailand were included this study. Expression levels androgen receptor, CD8, Forkhead box transcription factor C1, Doublecortin-like...

Cisplatin combined with gemcitabine, a doublet regimen, is the first-line treatment for patients advanced lung adenocarcinoma (ADC); however, response remains poor. This study aimed to identify potential biomarkers predicting cisplatin and gemcitabine. Tissue transcriptome blood proteome analyses were conducted on 27 ADC. Blood-derived proteins that reflected tissue-specific obtained using Venn diagrams. The candidate validated by Western blotting. Lentivirus-mediated short hairpin RNA...

Objective: Some endometrial biopsies from patients with atypical hyperplasia/endometrial intraepithelial neoplasia (AH/EIN) show concurrent endometrioid carcinoma (EC). Hysterectomy is the standard treatment for AH/EIN; however, hormonal therapy also acceptable women who wish to preserve fertility. Few studies have simultaneously evaluated expressions of PTEN and ARID1A in predict EC. This study aim whether loss indicate presence Material Methods: Endometrial 46 AH/EIN underwent hysterectomy...

To determine whether the p53 protein expression which is involved in genesis and progression of various malignant tumours may relate to age, sites or aggressive histopathological feature basal cell carcinoma. METHODS ADN RESULTS: One hundred fifty-eight carcinoma specimens from Songklanakarind Hospital, southern Thailand, collected January 1992 December 2000, were examined by immunohistochemistry using polyclonal anti-p53-CM1 (Novocastra Laboratories, Newcastle, UK; dilution 1:700). was...

Since the introduction of image pattern recognition and computer vision processing, classification cancer tissues has been a challenge at pixel-level, slide-level, patient-level. Conventional machine learning techniques have given way to Deep Learning (DL), contemporary, state-of-the-art approach texture localization tissues. Colorectal Cancer (CRC) is third ranked cause death from worldwide. This paper proposes image-level CRC dataset by deep convolutional neural networks (CNN). Simple DL...

<h3>Objective:</h3> MicroRNA (miRNA), a short noncoding RNA, is claimed to be potential blood-based biomarker. We aimed identify and evaluate miRNAs as diagnostic biomarkers for non-small cell lung cancer (NSCLC). <h3>Methods:</h3> Profiles of 745 were screened in the serum 8 patients with NSCLC age- sex-matched controls using TaqMan low-density arrays (TLDAs) validated 25 30 other diseases (OLs) well 19 healthy persons (HPs). The performance candidate was assessed 117 cases 113 OLs...

Diabetes mellitus is widely thought to be a risk factors of cancers, but evidence the association remains inconclusive, especially in Asian countries where few relevant studies have been conducted. Our study aimed estimate overall and specific types cancer risks among diabetes patients Southern Thailand. Patients diagnosed with who visited outpatient clinic Songklanagarind Hospital during 2004 2018 were included. Newly identified using hospital-based registry. Age-standardized incidence...

Background: Epithelial ovarian cancer (EOC) is the leading cause of death in gynecological cancers developed countries. In recent years, there has been a growing need for economical and accurate pretreatment laboratory investigations to assess prognosis patients with advanced EOC (AEOC). We aimed investigate role hemoglobin-albumin-lymphocyte-platelet (HALP) index suboptimal cytoreduction oncological outcomes. Methods: A prognostic prediction model diagnosing AEOC receiving neoadjuvant...

Background/Aim: 14-3-3γ is involved in the metastasis of lung cancer cells. However, its functional roles tumor cell invasion and underlying mechanisms are still not understood. In this study, molecular epithelial–mesenchymal transition (EMT), migration, were investigated using A549 H358 non-small (NSCLC) lines. Materials Methods: siRNA against was used to suppress expression. Expression levels proteins detected by western blotting. Activity matrix metalloproteinases (MMP)-2 MMP9 determined...

Background: Several studies have focused on the clinical outcomes of oral care using colostrum for a limited time (2–5 days) in very-low-birthweight (VLBW) infants. However, effect long-term mother’s own milk (MOM) and microbiota VLBW infants remains unknown. Methods: In this randomized controlled trial, neonates were randomly assigned to by MOM or sterile water (SW) groups until they started feeding. The primary outcome was composition including alpha beta diversity, relative abundance,...

Background: This study aimed to evaluate the expression of class III β-tubulin (TUBB3), ribonucleoside-diphosphate reductase 1 (RRM1), apurinic/apyrimidinic endonuclease (APE1), and survivin in patients with advanced non-small cell lung cancer (NSCLC) predict response chemotherapy. Methods: TUBB3, RRM1, APE1, levels were determined using immunohistochemistry. Protein was validated Car/Pac-resistant human H1792 A549 cells. included 86 patients, among whom 34 received cisplatin...

Background: Persistent high-risk human papillomavirus (HPV) infection is one of the major etiologies oropharyngeal squamous cell carcinoma (OPSCC). This study aimed to determine proportion, temporal trend, and prognostic significance HPV-related OPSCC in Thai patients. Methods: The included patients with who were treated at Songklanagarind Hospital (Songkhla, Southern Thailand) from 2009 2020. HPV status was screened by p16 expression using immunohistochemistry confirmed real-time polymerase...