A5065498868- Traditional and Medicinal Uses of Annonaceae
- Cocoa and Sweet Potato Agronomy
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Carbohydrate Chemistry and Synthesis
- Synthesis and Biological Evaluation
- Plant and Fungal Species Descriptions
- Research on Leishmaniasis Studies
- Chemical Synthesis and Reactions
- Oxidative Organic Chemistry Reactions
- Phytochemical compounds biological activities
- Trypanosoma species research and implications
- Cyclopropane Reaction Mechanisms
- Chemical Synthesis and Analysis
- Parkinson's Disease Mechanisms and Treatments
- Catalytic C–H Functionalization Methods
- Natural product bioactivities and synthesis
- Catalytic Cross-Coupling Reactions
- Malaria Research and Control
- Asymmetric Hydrogenation and Catalysis
- Chemical synthesis and alkaloids
- Marine Sponges and Natural Products
- Catalysis and Oxidation Reactions
- Catalytic Processes in Materials Science
- Cholinesterase and Neurodegenerative Diseases
Centre National de la Recherche Scientifique
2016-2025
Université Paris-Saclay
2016-2025
Laboratoire des Biomolécules
2020-2024
Institut de Chimie des Substances Naturelles
2000-2022
Université Paris-Sud
2012-2021
Institut Galien Paris-Saclay
2003-2019
Université Paris Cité
2000-2016
Institut National des Sciences Appliquées Rouen Normandie
2016
Université de Rouen Normandie
1993-2016
Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique
2012-2016
The endoperoxide scaffold is found in numerous natural products and synthetic substances of pharmaceutical interest. main challenge to their access remains the preparation chiral compounds due weakness peroxide bond, which limits scope available or applicable methods. Here, we demonstrate how peroxycarbenium species can be trapped by silylated nucleophiles with high enantioselectivities diastereoselectivities when applicable, using a imidophosphorimidate (IDPi) as catalyst. methodology...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSyntheses of Acetogenins Annonaceae: A New Class Bioactive PolyketidesBruno FigadereCite this: Acc. Chem. Res. 1995, 28, 9, 359–365Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/ar00057a001https://doi.org/10.1021/ar00057a001research-articleACS PublicationsRequest reuse permissionsArticle Views501Altmetric-Citations120LEARN ABOUT THESE...
Dengue virus is the world's most prevalent human pathogenic arbovirus. There currently no treatment or vaccine, and solutions are urgently needed. We previously demonstrated that biflavonoids from <i>Dacrydium balansae</i>, an endemic gymnosperm New Caledonia, potent inhibitors of NS5 RNA-dependent RNA polymerase. Herein we describe structure-activity relationship study 23 compounds: <i>D. balansae</i> (<b>1</b>–<b>4</b>) araucarioides</i> (<b>5</b>–<b>10</b>), hexamethyl-amentoflavone...
A stepwise addition of 2-trimethylsilyloxyfuran (2-TMSOF) to achiral aldehydes in the presence a chiral Lewis acid, such as (R)-(1,1′-bi-2-naphthol)2Ti complex, affords corresponding butenolides [Eq. (1)] good yields with excellent ee values (70 96 % ee). This is first reported catalytic asymmetric autoinductive aldol reaction.
Several studies have reported that the tetracycline (TC) class antibiotic doxycycline (DOX) is effective against Parkinson's disease (PD) pathomechanisms. The aim of present work was three-fold: (i) Establish a model system to better characterize neuroprotection by DOX; (ii) Compare rescue effect DOX other TC antibiotics; (iii) Discover novel neuroprotective TCs having reduced activity. For that, we used cultures mouse midbrain dopamine (DA) neurons and experimental conditions iron-mediated...
We report in this study the vivo efficacy of nine 2-substituted quinolines on Leishmania amazonensis cutaneous infection murine model and infantum donovani visceral models. In case L. model, were administered orally at 25 mg/kg twice daily for 15 days. Quinolines 1, 2, 3, 7 reduced by 80 to 90% parasite burdens lesion, whereas N-methylglucamine antimoniate (Glucantime), subcutaneous injections 100 mg [28 Sb(V)] per kg body weight daily, 98%. leishmaniasis due infantum, mice treated 10 days...
Two new coumarin compounds (1 and 2), phebalosin (3), its derived artifact murralongin (4), murrangatin acetonide (5) were isolated from the leaves of Galipea panamensis. The structures 1 2 assigned as 7-{[(2R*)-3,3-dimethyloxiran-2-yl]methoxy}-8-[(2R*,3R*)-3-isopropenyloxiran-2-yl]-2H-chromen-2-one 7-methoxy-8-(4-methyl-3-furyl)-2H-chromen-2-one, respectively, on basis their spectroscopic data (primarily NMR MS). Compounds 1−3 tested against axenic amastigote forms Leishmania panamensis...
The antiproliferative activities of six medicinal plant extracts from Burkina Faso were evaluated in order to justify their traditional use for the treatment cancer. SOS chromotest method was used vitro on Escherichia coli PQ37 evaluate mutagenic effect extracts. DPPH antioxidant activity each plant. by MTS normal cells (Vero and MCR5) cancer (KB) contact with 72 h. results showed that studied plants are not genotoxic. Lantana ukambensis Acacia macrostachya induced a very significant against...
<ns4:p>The ongoing Ebola virus epidemic has presented numerous challenges with respect to control and treatment because there are no approved drugs or vaccines for the disease (EVD). Herein is proposed simple theoretical criterion fast virtual screening of molecular libraries candidate inhibitors infection. We performed a repurposing screen 6438 from DrugBank using this selected 267 382 experimental as candidates EVD including 15 anti-malarial 32 antibiotics. An open source Web server...