A5113948114- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Epigenetics and DNA Methylation
- Melanoma and MAPK Pathways
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Retinopathy of Prematurity Studies
- Birth, Development, and Health
- Injury Epidemiology and Prevention
- Alzheimer's disease research and treatments
- Nicotinic Acetylcholine Receptors Study
- Renal and related cancers
- Trauma and Emergency Care Studies
- Pluripotent Stem Cells Research
- Neurobiology and Insect Physiology Research
- Emergency and Acute Care Studies
- Corneal Surgery and Treatments
- Meat and Animal Product Quality
- Allergic Rhinitis and Sensitization
- Retinal Development and Disorders
- Identification and Quantification in Food
- Cancer Cells and Metastasis
- Cholinesterase and Neurodegenerative Diseases
Chinese University of Hong Kong
2009-2025
University of Hong Kong
2025
Monash University
2007
Abstract Accumulation of the amyloid protein (Aβ) in brain is an important step pathogenesis Alzheimer’s disease. However, mechanism by which Aβ exerts its neurotoxic effect largely unknown. It has been suggested that peptide can bind to α7 nicotinic acetylcholine receptor (α7nAChR). In this study, we examined binding Aβ1‐42 endogenous and recombinantly expressed α7nAChRs. did neither inhibit specific α7nAChR ligands rat homogenate or slice preparations, nor it influence activity α7nAChRs...
Crustacean shellfish is one of the eight most common food allergens, and crayfish a highly valued species for consumption in China. However, detailed allergen profile remains unknown, with only four groups reported WHO/IUIS nomenclature database. In this study we aimed to identify novel allergens based on Procambarus clarkii genome reveal its developing better diagnostic tools treatments. We assembled using both long-read short-read sequencing data identified putative BLAST algorithm...
Melanoma is a highly lethal form of skin cancer due to its propensity for metastasis through angiogenesis, which confers melanoma initiating cells with resistance BRAF and MEK inhibitors. However, current drugs targeting angiogenesis have shown limited efficacy, highlighting the need develop new anti-angiogenic therapies effectively combat this devasting malignancy. Here, we found that Follistatin-like 1 (FSTL1) expression significantly increased in metastatic melanoma, correlates higher...
Glaucoma is characterized by retinal ganglion cell (RGC) degeneration and the second leading cause of blindness worldwide. However, current treatments such as eye drop or surgery have limitations do not target loss RGC. Regenerative therapy using embryonic stem cells (ESCs) holds a promising option, but ethical concern hinders clinical applications on human subjects. In this study, we employed spermatogonial (SSCs) an alternative source ESCs for cell-based regenerative in mouse glaucoma...
What is the transcriptome signature associated with poor performance of rescue IVM (rIVM) oocytes and how can we rejuvenate them?The GATA-1/CREB1/WNT signalling axis was repressed in rIVM oocytes, particularly those quality; restoration this may produce more usable oocytes.rIVM aims to mature (MII) for IVF through immature collected from stimulated ovaries. It not popular due limited success rate infertility treatment. Genetic aberrations, cellular stress absence cumulus cell support could...
Abstract Background Epithelial-mesenchymal transition (EMT) is a phenomenon in which epithelial cells acquire mesenchymal traits. It contributes to organogenesis and tissue homeostasis, as well stem cell differentiation. Emerging evidence indicates that heterogeneous expression of EMT gene markers presents sub-populations germline (GSCs). However, the functional implications such heterogeneity are largely elusive. Results We unravelled an EMT-like process GSCs by vitro extracellular matrix...
The issue of advanced maternal age (AMA) has become a global issue, the average increased dramatically through past decades. In vitro fertilization (IVF) is generally presented as viable option but success rate limited by age. low also compound subjective visual quality assessment, which creates huge challenge for AMA women. A novel genetic‐based oocyte assessment platform prediction using mouse oocytes had been developed in this study. Based on transcription profile both immature (GV) and...
Abstract Background Advanced maternal aging has become a worldwide public health issue that contributes to female fertility decline and significant risk embryo development. Despite transcriptional epigenetic alterations reported in oocyte maturation development, the dynamics of gene expression DNA associated with remain elusive. Here we generated simultaneous transcriptome methylome profiles mouse oocytes during at single-cell single-base resolution examine key biological processes identify...
Background Asian carps are popular freshwater fish species in Hong Kong and served as an important protein source for infants. Grass carp parvalbumin was reported to have higher allergenicity than other commercially fishes (salmon cod) terms of IgE reactivity. Objective To identify allergens study the divergence pattern allergens. Method Three complete carps’ genomes were constructed by hybrid assembly approach. All homologs known putative identified based on sequence homology at genomic...