A5014801711- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory and Cough-Related Research
- Allergic Rhinitis and Sensitization
- Respiratory Support and Mechanisms
- Inhalation and Respiratory Drug Delivery
- Sarcoidosis and Beryllium Toxicity Research
- Congenital Heart Disease Studies
- COVID-19 Clinical Research Studies
- Frailty in Older Adults
- Neonatal Respiratory Health Research
- Lung Cancer Treatments and Mutations
- SARS-CoV-2 and COVID-19 Research
- Cardiac and Coronary Surgery Techniques
- Inflammatory Myopathies and Dermatomyositis
- Aortic Disease and Treatment Approaches
- Intensive Care Unit Cognitive Disorders
- Coronary Artery Anomalies
- Eosinophilic Disorders and Syndromes
- Dental Health and Care Utilization
- Tracheal and airway disorders
- Nutrition and Health in Aging
- Pleural and Pulmonary Diseases
- Health and Wellbeing Research
Yamaguchi University
2016-2025
National Sanyo Hospital
2013-2024
Tokushima University
1990-2022
University of Newcastle Australia
2019
John Hunter Hospital
2019
Hunter Medical Research Institute
2019
Yamaguchi University Hospital
2017
Ube (Japan)
2015
Fujitsu (Japan)
2008-2009
Nagaoka National College of Technology
2006
During tooth development, after the completion of crown formation, apical mesenchyme forms developing periodontium while inner and outer enamel epithelia fuse below level cervical margin to produce a bilayered epithelial sheath termed Hertwig's root (HERS). The role HERS cells in formation is widely accepted; however, precise function these remains controversial. Functions suggested have ranged from structural (subdivide dental ectomesenchymal tissues into papilla follicle), regulators...
Recent advances in biologics have provided new insights into the clinical course of asthma, including disease modification, remission (CR), and deep (DR). However, extent to which achieve CR DR severe asthma patients is poorly understood.To assess achievement rate predictors using long-term biologics, we retrospectively evaluated 54 recently started on biologics. "CR" denotes all three criteria: (1) absence symptoms, (2) no exacerbations, (3) use oral corticosteroids. denoted plus (4)...
Objective Acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) are fatal episodes acute respiratory worsening unknown etiology. Previous studies on distress syndrome have shown that direct hemoperfusion with a polymyxin B-immobilized fiber column (PMX-DHP) can beneficial effect the status. This retrospective study investigated prognosis and survival outcome patients AE-IPF who underwent PMX-DHP. Methods We examined records 50 treated in our hospital. All received corticosteroid...
Abstract Although the 6 min walk test (6MWT) is well-established for assessing desaturation in patients with interstitial lung disease (ILD), it cannot be easily performed primary healthcare settings. This retrospective observational study aimed to evaluate usefulness of 1 sit-to-stand (1STST) during 6MWT ILD normal resting blood oxygen levels. We included 116 patients, and pulse saturation (SpO 2 ) both methods was analyzed. The SpO nadir 1STST correlated strongly (ρ = 0.82). frequency <...
Objective: Asthma is frequently associated with chronic rhinosinusitis nasal polyps (CRSwNP). Although endoscopic sinus surgery (ESS) improves asthma control in CRSwNP patients asthma, the mechanism that underlies response to surgical treatment still unclear. We evaluated relevance of changes and airway/systemic inflammation eosinophilic not well controlled who underwent ESS.Methods: prospectively assessed questionnaire (ACQ) score, blood eosinophil counts (B-Eos), forced expiratory volume 1...
(1) Background: Reduced lung function in early adulthood is associated with future risks to health outcomes that have not been fully explored by gender. We investigated gender-specific relationships between and extrapulmonary variables, assessing their potential as screening markers for respiratory dysfunction young adults. (2) Methods: The participants were 151 medical students. Clinical data, handgrip strength (HS); body composition parameters such skeletal muscle mass index (SMI),...
Chronic obstructive pulmonary disease (COPD) is a heterogeneous inflammatory lung disease. It important to identify patients who would respond anti-inflammatory treatment. This prospective study aims determine how biomarkers could be used predict the potential effect of inhaled corticosteroids (ICS) in terms symptoms and function. We evaluated levels blood eosinophils, exhaled nitric oxide fraction at flow rate 50 ml s-1 (FeNO), alveolar concentration (Calv), immunoglobulin E atopy 43 with...
Abstract Background The magnitude and durability of cell-mediated immunity in older severely frail individuals following coronavirus disease 2019 (COVID-19) vaccination remain unclear. A controlled immune response could be the key to preventing severe COVID-19; however, it is uncertain whether induces an anti-inflammatory cellular response. To address these issues, a 48-week-long prospective longitudinal study was conducted. total 106 infection-naive participants (57 long-term care facility...
Yellow nail syndrome (YNS), a rare condition characterized by thickened yellow nails, lymphedema, and respiratory manifestations, is rarely caused bucillamine, an anti-rheumatic agent. Respiratory manifestations of YNS include chylothorax in 18.8%-22% patients with pleural effusion. We herein report the first case bucillamine-induced chylothorax. Lymphangiography revealed narrowing lymphatic vessels stagnation fluid, suggesting impaired drainage. The persisted despite discontinuation...
IgG4 ‐related disease ( ‐ RD ) is a recently designated entity and its full picture has not yet been elucidated. Here, we report an unusual case of patient with gastric wall thickening secondary to . A 68‐year‐old male visited our hospital itchy skin lesions episode organizing pneumonia. On the suspicion malignancy‐associated lesions, computed tomography CT was performed. The revealed prominent wall. Due possibility malignancy, underwent distal gastrectomy. Histopathological examination...
Sedentary behavior and cognitive impairment have a direct impact on patients’ outcomes. An energy metabolic disorder may be involved in the overlap of these comorbid conditions (motoric risk (MCR)) patients with chronic obstructive pulmonary disease (COPD). We aimed to explore linkage between proapoptotic protein, growth differentiation factor (GDF)-15, MCR. Physical activity (PA), function (Japanese version Montreal Cognitive Assessment: MOCA-J), serum GDF-15 levels were assessed healthy...
Type 2 (T2) inflammation plays an important role in the pathogenesis of allergic diseases such as asthma, eosinophilic chronic rhinosinusitis (ECRS), or otitis media (EOM). Currently, severe asthma with T2 phenotype, biologics targeting mediators dramatically improve management asthma. While treatment a single biologic is common, little known about cases sequential use two biologics. Here, we report case refractory ECRS and EOM which total control these could not be achieved but via...
Abstract Physical inactivity and cognitive impairment in patients with chronic obstructive pulmonary disease (COPD) can lead to frailty poor prognoses. However, little is known regarding the association between human brain. We hypothesized that brain structure could change according COPD focused on cortical thickness. Cortical thickness measured by magnetic resonance imaging scores using Kihon Checklist (KCL) were assessed 40 stable 20 healthy controls. Among 34 regions assessed, multiple...
Abstract Introduction The fraction of exhaled nitric oxide (FeNO) and blood eosinophils, markers local systemic eosinophilic inflammation, respectively, are increased in asthmatic patients. Little is known concerning the relationship between FeNO levels eosinophils asthmatics. Methods Twenty severe asthmatics with persistent elevation (≥40 ppb) eosinophilia (≥3%) despite maintenance therapy including high‐daily‐dose inhaled corticosteroids were analyzed. We investigated response to treatment...