A5013440267- Mollusks and Parasites Studies
- Parasite Biology and Host Interactions
- Parasitic infections in humans and animals
- Toxoplasma gondii Research Studies
- Medical and Biological Ozone Research
- Parasitic Infections and Diagnostics
- Helminth infection and control
- Bone Tissue Engineering Materials
- Hemostasis and retained surgical items
- Coccidia and coccidiosis research
- Legionella and Acanthamoeba research
- Parasitic Diseases Research and Treatment
- Invertebrate Immune Response Mechanisms
- Cerebrospinal fluid and hydrocephalus
- Protease and Inhibitor Mechanisms
- Barrier Structure and Function Studies
- Mosquito-borne diseases and control
- Peptidase Inhibition and Analysis
- Cytomegalovirus and herpesvirus research
- Parasites and Host Interactions
- Selenium in Biological Systems
- Heme Oxygenase-1 and Carbon Monoxide
- Nanoparticles: synthesis and applications
- Infectious Aortic and Vascular Conditions
- Vanadium and Halogenation Chemistry
Chung Shan Medical University
2015-2025
Chung Shan Medical University Hospital
2009-2025
China Pharmaceutical University
2024
National Chung Hsing University
2001-2002
Lung cancer is among the most common causes of cancer-related mortality. It has a high mortality rate and resistance to chemotherapy due its metastatic potential. Naringenin, bioactive compound identified in several fruits, displays anti-inflammatory antitumor effects. Furthermore, naringenin mitigates migration human cell types. However, effects on lung remain unclear. The current study investigated mechanisms A549 cells. results indicate that significant alteration proliferation was...
The epithelial barrier regulates the movement of ions, macromolecules, immune cells and pathogens. objective this study was to investigate role matrix metalloproteinase (MMP)-9 in degradation tight junction protein during infection with rat nematode lungworm Angiostrongylus cantonensis. results showed that phosphorylation IκB NF-κB increased mice eosinophilic meningoencephalitis. Treatment MG132 reduced activity MMP-9, indicating upregulation MMP-9 through signaling pathway. Claudin-5 brain...
Hemolymph coagulation began almost immediately after wounding in mosquito, Armigeres subalbatus, (Coquillett) larvae. Immunocytochemical localization showed that prophenoloxidase (pro-PO) was distributed the wound site. In initial wounding, and plug formation occurred with granulocyte migration. The hemocytes lysed released granular materials around site, being mostly localized granules cuticle. second phase of healing, melanin accumulation at site along margin cuticle rapidly increased...
ObjectivesTo evaluate the curative effect of albendazole/thalidomide co-therapy on eosinophilic meningitis in BALB/c mice caused by Angiostrongylus cantonensis.
Abstract Emerged evidence indicated that stimulating hippocampal neurogenesis is a potential strategy for restoring cognition in AD. Mitogen‐activated protein kinases (MAPKs) play an essential role neurogenesis. Meanwhile, the enzymatic power of phosphatases much greater than kinases. Dual‐specificity phosphatase 16 (DUSP16), known to as negatively regulate MAPKs, may be implicated neural differentiation. Nevertheless, effect DUSP16 on cognitive disorders by progenitor cell (NPC)...
Summary Blood–central nervous system (blood–CNS) barrier breakdown, an important pathophysiological event in meningitis, results extravasation of leucocytes into subarachnoid space. The blood–CNS disruption is mediated by primarily two enzyme systems, the plasminogen activators (PAs) and matrix metalloproteinases (MMPs). present study showed that activities tissue‐type PA (tPA), urokinase‐type activator (uPA) MMP‐9 cerebrospinal‐like fluid (CSF‐like fluid) were significantly increased mice...
Here we reported the first case in Taiwan of human intestinal myiasis caused by larvae Telmatoscopus albipunctatus. The 21-year-old male patient experienced gastroenteritis and anal itching. During patient's hospital visit doctor suspected Enterobius infection. After treatment with anthelmintic mebendazole, 5 live were passed out feces. Symptoms resolved a few days later. brown slender, measuring approximately 10 mm length. worms located intestine. Subsequent examination showed that cause...
Summary Pulmonary granuloma formation and fibrosis were experimentally induced in Sprague–Dawley strain rats by Angiostrongylus cantonensis . Increased protein levels of matrix metalloproteinase (MMP)‐2, ‐9, ‐13 the imbalance between these enzymes inhibitors, tissue inhibitors MMPs (TIMP‐1 ‐2), occur during granulomatous fibrosis. Activation proteolytic (MMP‐2, ‐9 ‐13) fibronectin degradation simultaneously. Furthermore, present study demonstrated that avidly binds MMP‐2, or ‐13....
Matrix metalloproteinases (MMP) have been implicated in the pathogenesis of various inflammatory diseases central nervous system. In present study, a gelatinase was found to be induced parasitic meningitis caused, mice, by Angiostrongylus cantonensis. The enzyme had molecular weight about 94 kDa, showed maximal activity between pH 6 and 8, clearly inhibited EDTA 1,10-phenanthroline but not leupeptin or phenylmethanesulphonyl fluoride. When samples cerebrospinal fluid from mice with were...
The wound-healing processes in the mosquito Armigeres subalbatus (Coquillett) were observed with electron microscopy. initial reaction involved wound contractions and aggregation of injured surface tissues, cell debris movement granulocytes toward wound. Granulocytes first aggregated around many filamentous filopodia protruded to connect cytoplasmic strands. These strands then interconnected form a network coagulum resulting closure prevent body fluid loss. lysed on wound-site released...
A 62‐year‐old woman presented with unilateral eye swelling and itching. Subsequent examination showed the cause was an infestation of parasitic worm Thelazia callipaeda. The vector leading to human infection is fly. possible mechanisms for this patient are discussed. Although a known form ocular infection, especially in Asia, one few reported cases Taiwan.
Abstract Angiostrongylus cantonensis can invade the central nervous system, leading to human eosinophilic meningitis or meningoencephalitis. Curcumin is a natural product which has effects of anti-inflammation, anti-oxidation and anti-carcinogensis, while administration curcumin been reported possibly relieve symptoms meningitis. The present study tested potential efficacy in A. -induced BALB/c mice. Assay indicators for therapeutic effect included larvicidal effect, eosinophil counts matrix...