A5101450925- Pharmacogenetics and Drug Metabolism
- Alzheimer's disease research and treatments
- Pharmacological Effects of Natural Compounds
- Plant Toxicity and Pharmacological Properties
- Microbial Metabolism and Applications
- Metabolomics and Mass Spectrometry Studies
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Drug-Induced Hepatotoxicity and Protection
- Dementia and Cognitive Impairment Research
- Metabolism and Genetic Disorders
- Neurogenesis and neuroplasticity mechanisms
- Autophagy in Disease and Therapy
- Sugarcane Cultivation and Processing
- Neurological Disease Mechanisms and Treatments
- Computational Drug Discovery Methods
- Analytical Chemistry and Chromatography
- Traditional Chinese Medicine Analysis
- Estrogen and related hormone effects
- Cancer Treatment and Pharmacology
- Plant-based Medicinal Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Biochemical and biochemical processes
- Bioactive natural compounds
- Medicinal Plants and Neuroprotection
China Pharmaceutical University
2013-2025
Guangxi Medical University
2015-2025
Shandong Academy of Sciences
2022-2024
Qilu University of Technology
2022-2024
West Anhui University
2021
Anhui University of Traditional Chinese Medicine
2021
Boston Children's Hospital
2013
Chinese University of Hong Kong
2002-2003
The aim of this study was to examine the comprehensive neuroprotective mechanism ligustrazine, which is extracted from Ligusticum Chuanxiong Hort., against vascular dementia (VD) in rats and apoptosis oxygen glucose deprivation (OGD) PC12 cells. Rats were subjected bilateral common carotid artery occlusion (BCCAO) surgery administered ligustrazine intragastrically for 6 weeks. At end experiments, hippocampal biomarkers brain-derived neurotrophic factor (BDNF), monocyte chemotactic protein 1...
Prodigiosin (PG) is a secondary metabolite produced by Serratia marcescens which has promising future in food, textile, and other industries due to its bright color diverse biological activities. Currently, the production of PG mainly restricted components fermentation medium large losses during extraction process, making large-scale industrial impossible. In this study, Box–Behnken design (BBD) was used optimize response surface S. marcescens. The optimum composition found be sucrose, 16.29...
The risk of diabetic cardiovascular complications is closely linked to the length hyperglycemia exposure. Mitophagy plays a significant role in vascular endothelial injury. However, specific mechanisms by which mitophagy contributes injury during sustained remain unclear. In ApoE-/- mice and human umbilical vein cell (HUVEC) models, enhanced following short-term long-term high-glucose Short-term exposure promotes Parkin-mediated upregulates mitochondrial fission protein 1 (Fis1) expression,...
Bartonella spp. are emerging, potentially zoonotic pathogens that most often transmitted by arthropod vectors or animal bites and scratches. However, the vector species involved in transmission of human bartonellosis remain poorly understood. This study investigated presence Triatoma rubrofasciata from Guangxi Hainan provinces China, evaluating its potential role as a for disease. was identified T. samples through PCR amplification sequencing ITS, gltA, rpoB genes. The survival duration...
Emerging evidence shows that mitochondria fusion/fission imbalance is related to the occurrence of hyperglycemia-induced vascular injury. To study temporal dynamics mitochondrial fusion and fission, we observed alteration proteins in a set different high-glucose exposure durations, especially early stage hyperglycemia. The vitro results show persistent cellular apoptosis endothelial dysfunction can be induced rapidly within 12 hours' pre-incubation. Our maintain normal morphology function 4...
The gender differences in the vitro microsomal metabolic activation of hepatotoxic clivorine, a representative naturally occurring otonecine type pyrrolizidine alkaloid, Sprague−Dawley rats and their relation to susceptibility clivorine intoxication were reported present study. Clivorine-induced liver damage male rat via form reactive pyrrolic ester followed by covalent binding tissue constituents has been previously our research group. study demonstrated, for first time, that cytochromes...
Clivorine is a representative naturally occurring hepatotoxic otonecine-type pyrrolizidine alkaloid. Our previous study has demonstrated that clivorine induces liver damage via metabolic activation to form the reactive pyrrolic ester followed by covalent binding tissue constituents. The present investigated species differences in vitro of male rat and guinea pig both sexes. In rat, was found as only pathway. Moreover, toxic tissue-bound pyrroles four isolatable metabolites identified, namely...
Abstract Emerged evidence indicated that stimulating hippocampal neurogenesis is a potential strategy for restoring cognition in AD. Mitogen‐activated protein kinases (MAPKs) play an essential role neurogenesis. Meanwhile, the enzymatic power of phosphatases much greater than kinases. Dual‐specificity phosphatase 16 (DUSP16), known to as negatively regulate MAPKs, may be implicated neural differentiation. Nevertheless, effect DUSP16 on cognitive disorders by progenitor cell (NPC)...
Abstract Mild cognitive impairment (MCI) is a precursor phase of Alzheimer’s disease (AD). As current treatments may be effective only at the early stages AD, it important to track MCI patients who will convert AD. The aim this study develop high performance semi-mechanism based approach predict conversion from AD and improve our understanding MCI-to-AD mechanism. First, analysis variance (ANOVA) test lasso regression are employed identify markers related conversion. Then Bayesian network on...
Abstract A phenylhexyl isothiocyanate (PITC) precolumn derivatization quantitative analysis of multicomponents by a single marker (QAMS) strategy for the simultaneous 20 free amino acids (FAA) in Dendrobium huoshanense is proposed. The method was validated linearity, limit detection (LDO), and quantitation (LOQ), recovery, precision, stability. results showed that when applying established method, LOQ FFAs lower than 1 ng/ml except threonine (1.32 ng) cysteine (1.16 ng). QAMS investigation...
Alzheimer's disease (AD) is age-related progressive neurological dysfunction. Limited clinical benefits for current treatments indicate an urgent need novel therapeutic strategies. Previous transcriptomic analysis showed that DMP1 expression level was increased in AD model animals whereas it can induce cell-cycle arrest several cell lines. However, whether the of neural progenitor induced by affects cognitive function Alzheimer-like mice still remains unknown. The objective our study to...
The impact of mitochondrial haplogroups on Alzheimer's disease (AD) risk has not been fully elucidated and warrants further investigation at the subgroup level.The aim this research is to evaluate association between AD in subgroups level.In total, 809 Neuroimaging Initiative subjects were assessed using mtDNA sequencing, Assessment Scale-Cognitive Subscale (ADAS-cog), hippocampal volume measurements, hypometabolic convergence index (HCI), MCI-to-AD conversion proportion measurements.The...
Aβ, tau and P-tau have been widely accepted as reliable markers for Alzheimer's disease (AD). The crosstalk between these forms a complex network. AD may induce the integral variation disruption of aim this study was to develop novel mathematic model based on simplified network evaluate progression AD. is measured by three parameters. robustness evaluated probability. Presented results show that probability has good linear relationship with Mini Mental State Examination (MMSE). proposed...
Abstract Objectives The goal of this study was to establish an integrated indirect response pharmacokinetic-pharmacodynamic model between telmisartan and hydrochlorothiazide describe the antihypertensive interaction these two drugs in spontaneously hypertensive rats. Methods blood pressure plasma concentrations were measured by tail-cuff test high performance liquid chromatographyߝmass spectrometry, respectively, current pharmacokinetic–pharmacodynamic based on non-competitive...