A5015654228- Chronic Kidney Disease and Diabetes
- Artificial Intelligence in Healthcare
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Research
- Traditional Chinese Medicine Studies
- Machine Learning in Healthcare
- GDF15 and Related Biomarkers
- MicroRNA in disease regulation
- Metabolism, Diabetes, and Cancer
- Circular RNAs in diseases
- CRISPR and Genetic Engineering
- Autophagy in Disease and Therapy
- Parkinson's Disease Mechanisms and Treatments
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Bariatric Surgery and Outcomes
- RNA regulation and disease
- Diabetes and associated disorders
- Advanced Glycation End Products research
- Signaling Pathways in Disease
- Endoplasmic Reticulum Stress and Disease
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac Fibrosis and Remodeling
- Traditional Chinese Medicine Analysis
- Cancer-related molecular mechanisms research
Hainan Medical University
2021-2025
Central South University
2021
Second Xiangya Hospital of Central South University
2021
This study aimed to develop a diabetic kidney disease (DKD) prediction model using long short term memory (LSTM) neural network and evaluate its performance accuracy, precision, recall, area under the curve (AUC) of receiver operating characteristic (ROC) curve. The identified DKD risk factors through literature review physician focus group, collected 7 years data from 6,040 type 2 diabetes mellitus patients based on factors. Pytorch was used build LSTM network, with 70% for training other...
The risk of diabetic cardiovascular complications is closely linked to the length hyperglycemia exposure. Mitophagy plays a significant role in vascular endothelial injury. However, specific mechanisms by which mitophagy contributes injury during sustained remain unclear. In ApoE-/- mice and human umbilical vein cell (HUVEC) models, enhanced following short-term long-term high-glucose Short-term exposure promotes Parkin-mediated upregulates mitochondrial fission protein 1 (Fis1) expression,...
Purpose: To investigate the association of five obesity indices and variability these with diabetic kidney disease (DKD) in patients type 2 diabetes compare predictive validity markers for risk DKD this large longitudinal cohort study. Patients Methods: A total 2659 who did not have were enrolled between 2006 2019 at Lee's United Clinic Taiwan. Data collected each subject, including demographic data, personal medical history, clinical parameters calculated Body mass index (BMI), visceral...
Excessive oxidative stress, inflammation, and myocardial hypertrophy have been associated with diabetic cardiomyopathy (DCM). S14G-humanin (HNG) is a potent humanin analogue that has demonstrated cytoprotective effects in variety of cells tissues. However, the pharmacological function HNG not yet reported. In present study, we investigated protective against streptozotocin (STZ)-induced cardiac dysfunction mice. Myocardial mice was determined using Wheat Gem Agglutinin (WGA) staining. The...
To investigate the frequency, clinical phenotype, inflammatory cytokine levels and genetics of glutamic acid decarboxylase autoantibody (GADA)-positive phenotypic youth-onset type 2 diabetes.This nationwide, multicentre, cross-sectional study included 5324 newly diagnosed subjects with diabetes aged 15 years or older enrolled in LADA China study. GADA was screened 248 15-29 years. Subjects who presented as GADA-positive were defined having latent autoimmune youth (LADY). We added LADY, 1...
Abstract Objective To evaluate the impact of temporary insulin pump use during hospitalization on glycemia, postoperative complications, and cost/utilization in perioperative patients with diabetes. Methods Patients (n=159) type 2 diabetes hospitalized for elective surgery were recruited from three hospitals. Subjects categorized into group multiple daily subcutaneous injection according to their treatment therapy. Data collected at admission, discharge, 3 months post-discharge. Results CSII...
Abstract Background Adenosine deaminases acting on RNA 1 (ADAR1), an editing enzyme, holds a role in cancer, inflammation, and immunity. However, its specific function the nephropathy high-glucose-induced human renal tubular epithelial cells (HK-2) injury diabetic db/db mice is not clear. Methods This study explored expression characteristics of ADAR1 proximal mice, examining mechanism HK-2 cell injury. Furthermore, it elucidated molecular underlying protective effect ADAR1, regulation...
Diabetic nephropathy is one of the microvascular complications diabetes. This study aimed at investigating role and mechanisms salvianolic acid B (Sal B) in diabetic nephropathy. High glucose (HG)-induced human renal tubular epithelial HK-2 cells were treated with Sal B, BAY-60-6583 (agonist adenosine 2B receptor), or PSB-603 (antagonist receptor) for 24 h. Adenosine A2b receptor (ADORA2B), NACHT, leucine-rich repeat (LRR), pyrin (PYD) domains-containing protein 3 (NALP3), nuclear factor...