A5073371677- Phytochemicals and Antioxidant Activities
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Fermentation and Sensory Analysis
- Essential Oils and Antimicrobial Activity
- Horticultural and Viticultural Research
- Analytical Methods in Pharmaceuticals
- Natural Compound Pharmacology Studies
- Analytical Chemistry and Chromatography
- Plant tissue culture and regeneration
- Sesquiterpenes and Asteraceae Studies
- Advanced Chemical Sensor Technologies
- Plant Molecular Biology Research
- Bee Products Chemical Analysis
- Chromatography in Natural Products
- Insect and Pesticide Research
- Antibiotics Pharmacokinetics and Efficacy
- Analytical Chemistry and Sensors
- Pesticide Residue Analysis and Safety
- Bioactive natural compounds
- Biochemical Analysis and Sensing Techniques
- Free Radicals and Antioxidants
- Coenzyme Q10 studies and effects
- Phytochemistry and Bioactive Compounds
- Pharmacological Effects and Assays
Institute of Chemistry
2013-2024
Saints Cyril and Methodius University of Skopje
2015-2024
University of Ss. Cyril and Methodius in Trnava
2003-2023
PHI University Psychiatric Clinic - Skopje
2020
Institute of public health of Republic of Macedonia
2018
Saarland University
2013
The phenolic profile of four blueberry varieties (Vaccinium corymbosum L., cv. Toro, Legacy, Duke and Bluecrop) two (Rosenthal Rovada) red currants (Ribes rubrum L.) black nigrum cultivated in Macedonia have been analyzed using HPLC coupled to diode-array detection tandem mass spectrometry with electrospray ionization. A complex anthocyanins, flavonols, flavan-3-ols hydroxycinnamic acid derivatives has assayed acetone−acetic (99:1, v/v) extracts. Anthocyanins comprised the highest content...
Strawberry fruits contain phenolic compounds that exhibit antioxidant, anticancer, antiatherosclerotic, antinflammatory and anti-neurodegenerative properties. High-performance liquid chromatography (HPLC) coupled to electrospray ionization mass spectrometric (ESI-MS) detection in the positive negative ion mode has been used identify extracts from sixteen different strawberry cultivar Republic of Macedonia. Photodiode-array (DAD) for screening classes compounds, whereas MS MSn fragmentation...
Wines and grapes contain a large array of phenolic compounds belonging to non-flavonoids flavonoids. This study evaluates the polyphenolic contents six commercial red white Macedonian wines four grape varieties. Spectrophotometric methods were applied for determination total phenolics, flavonoids, anthocyanins catechins. The efficiency acetone/water (80/20) methanol/water solutions extraction polyphenols from pulp, seeds skins compared. best was achieved using acetone/ water. obtained...
Eight different solvent mixtures containing acetone or methanol pure combined with an acid (acetic, formic, hydrochloric) were tested for their efficiency extraction of phenolic compounds from strawberries belonging to five groups polyphenols: anthocyanins, flavonols, flavan-3-ols, hydroxycinnamic derivatives and conjugated forms ellagic acid. Twenty-eight these have been detected quantified using HPLC-DAD-ESI-MS(n). The yield each compound group was evaluated regard the composition. Acetone...
The aim of this study was to evaluate the phytochemical composition, antimicrobial activity and enzyme inhibitory properties roots (RO), non-flower shoots (NFS) flower (FS) Hypericum perforatum L. originating from Republic Macedonia. identification quantification phenolic compounds in plant material were performed by using HPLC/DAD/ESI–MSn analysis. on some selected species bacteria fungi tested microdilution assay. vitro extracts measured against key enzymes involved depression (monoamine...
Coenzyme Q10 (CoQ10) is one of the essential components mitochondrial electron-transport chain (ETC) with primary function to transfer electrons along and protons across inner membrane (IMM). The concomitant proton gradient IMM for process oxidative phosphorylation consequently ATP production. Cytochrome P450 (CYP450) monoxygenase enzymes are known induce structural changes in a variety compounds expressed IMM. However, it unknown if CYP450 interacts CoQ10 how such an interaction would...
Abstract Hypericum perforatum L. is a common perennial plant with reputed medicinal value. Investigations have been made to develop an efficient protocol for the identification and quantification of secondary metabolites in hairy roots (HR) HR were induced from root segments vitro grown seedlings H. perforatum, after co-cultivation Agrobacterium rhizogenes A4. Transgenic status was confirmed by PCR analysis using rolB specific primers. had altered phenolic profile respect acids, flavonol...
Twenty-one samples of Sideritis species (S. scardica, S. raeseri, taurica, syriaca and perfoliata) from various locations on the Balkan Peninsula were evaluated for their chemical constituents. Chemical analyses focused secondary metabolites, particularly phenolic compounds, which have several roles in plant physiological processes demonstrated significant health beneficial effects. The occurrence hydroxycinnamic acids, phenylethanoid glycosides flavonoids has been investigated taxonomically...
Benzoquinones (BQ) have important functions in many biological processes. In alkaline environments, BQs can be hydroxylated at quinoid ring proton positions. Very little is known about the chemical reaction leading to these structural transformations as well properties of obtained hydroxyl benzoquinones. We analyzed behavior naturally occurring 2,6-dimethoxy-1,4-benzoquinone under conditions and show that upon substitution methoxy-groups, poly-hydroxyl-derivatives (OHBQ) are formed. The...
Hypericum perforatum L. is a medicinal plant considered as an important natural source of secondary metabolites with wide range pharmacological attributes. Hairy roots (HR) were induced from root segments in vitro grown seedlings H. after cocultivation Agrobacterium rhizogenes A4. Investigations have been made to study the production phenolic compounds dark‐grown (HR1) and photoperiod‐exposed (HR2) cultures. The chromatographic analysis acids, flavonols, flavan‐3‐ols, xanthones revealed...
Polyphenolic and mineral profiles of berries leaves V. myrtillus (bilberry) uliginosum (bog bilberry) collected from northwestern Macedonia were examined in this study. Overall, 70 polyphenolic compounds identified various classes. Laricitrin-3-O-pentoside, trans- cis-piceid, hexahydroxydiphenoyl-galoyl-glucose, feruloyl-acetyl glucoside coumaroyl kaempferol for Vaccinium genus. Bilberries had higher total phenolic content than bog bilberry. Major differences the pattern found flavonols...
Flavonoids and other phenolic compounds in young needles of four pine species, Pinus peuce, P. nigra, mugo sylvestris from the Macedonian flora were investigated. The amount total phenols flavonoids determined using Folin-Ciocalteau aluminum chloride assay, respectively. obtained results revealed that content (TPC) (TFC) varied among different species ranging 9.8 to 14.0 mg GAE/g 3.3 7.2 CE/g dried plant material, Qualitative analysis components was made by a LC-DAD/ESI-MS(n) optimized...