A5100715972- Liver Disease Diagnosis and Treatment
- Sepsis Diagnosis and Treatment
- Machine Learning in Healthcare
- Hepatitis B Virus Studies
- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Phonocardiography and Auscultation Techniques
- Hepatitis C virus research
- Endoplasmic Reticulum Stress and Disease
- Cultural Differences and Values
- Platelet Disorders and Treatments
- Healthcare Technology and Patient Monitoring
- Mental Health Research Topics
- Face Recognition and Perception
- Endometriosis Research and Treatment
- Tea Polyphenols and Effects
- Human Resource Development and Performance Evaluation
- Blood properties and coagulation
- Categorization, perception, and language
- Traumatic Brain Injury and Neurovascular Disturbances
- Immune cells in cancer
- Mental Health via Writing
- Erythrocyte Function and Pathophysiology
- PI3K/AKT/mTOR signaling in cancer
- Pain Management and Placebo Effect
UNSW Sydney
2021-2025
First Affiliated Hospital of Wannan Medical College
2023-2024
Chongqing Medical University
2024
Ruijin Hospital
2021-2024
Shanghai Jiao Tong University
2024
Shandong Agricultural University
2020-2023
First Hospital of Jiaxing
2022
Nanjing University
2015-2016
Nanjing General Hospital of Nanjing Military Command
2016
Lanzhou University
2013
Abstract Resveratrol (3,5,4′‐trihydroxystilbene, RES), a star among dietary polyphenols, shows wide range of biological activities, but it is rapidly and extensively metabolized into its glucuronide sulfate conjugates as well to the corresponding reduced products. This begs question whether metabolites RES contribute in vivo activity. To explore this possibility, we synthesized glucuronidation (3‐GR 4′‐GR) reduction (DHR) metabolites, evaluated effect these structure modifications on...
Abstract Background Fatty liver is a high incidence of perinatal disease in dairy cows caused by negative energy balance, which seriously threatens the postpartum health and milk production. It has been reported that lysine acetylation plays an important role substance metabolism. Predictably, most metabolic processes liver, as vital organ, are subjected to acetylation. Comparative acetylome study were used quantify hepatic tissues from severe fatty group normal group. Combined with...
Abstract Background Progressive hepatitis B virus (HBV) infection can result in cirrhosis, hepatocellular cancer, and chronic hepatitis. While antiviral drugs that are now on the market efficient controlling HBV infection, finding a functional cure is still quite difficult. Identifying host factors involved regulating life cycle will contribute to development of new strategies. Zinc finger proteins have significant function replication, according earlier studies. protein 148 (ZNF148), zinc...
We aimed to develop an early warning system for real-time sepsis prediction in the ICU by machine learning methods, with tools interpretative analysis of predictions. In particular, we focus on deployment a target medical center small historical samples.Light Gradient Boosting Machine (LightGBM) and multilayer perceptron (MLP) were trained Medical Information Mart Intensive Care (MIMIC-III) dataset then finetuned private Historical Database local Ruijin Hospital (HDRJH) using transfer...
Abstract Background Menin is a scaffold protein encoded by the Men1 gene, which interacts with various transcriptional proteins to activate or repress cellular processes and key mediator in multiple organs. Both liver-specific hepatocyte-specific deficiency promotes high-fat diet-induced liver steatosis mice, as well insulin resistance type 2 diabetic phenotype. The potential link between hepatic metabolism homeostasis may provide new insights into mechanism of fatty disease. Results...
Hepatitis B virus (HBV) infection is a persistent global public health problem, and curing for chronic hepatitis (CHB) through the application of existing antiviral drugs beset by numerous challenges. The viral protein HBx critical regulatory factor in life cycle HBV. Targeting promising possibility development novel therapeutic strategies. Nano-Glo® HiBiT Lysis Detection System was used to screen herbal monomer compound library compounds that inhibit expression. Western blotting examine...
Sepsis is still a major health problem that causes high mortality in all populations. Organ dysfunction including sepsis-associated thrombocytopenia prevalent among sepsis patients, resulting increasing rates. Considering the clinical role of platelets, has led to large spend research activity and trials this area, yet there no consensus upon which treatment should be administered. As result, platelet transfusion often indicated resolve low counts, leading an risk multiple risks brings, such...
Background: Monocyte subsets and monocyte–platelet aggregates (MPAs) play important roles in inflammation. Aim: To evaluate the association between three human monocyte their contributions to MPAs mortality among septic patients. Methods: Consecutive patients were enrolled in. Age- gender-matched nonseptic recruited as control determined by flow cytometric analysis. Results: Elevated percentage of (MPAs%) was associated with an increased risk mortality. Conclusions: This study demonstrated...
Background: Recurrent Miscarriage (RM) is a chronic and heterogeneous autoimmune disease. Platelet factor 4 (PF4) has been found to be involved in the pathogenesis of RM. Objective: We aimed explore role mechanism PF4 on trophoblasts RM vitro. Methods: In this study, expression receptor CXC chemokine 3 (CXCR3) placentas patients with were analyzed by RT-qPCR western blotting. Serum level was tested ELISA. Following silencing SOCS3 overexpression HTR-8/SVneo cells, cell proliferation detected...
Abstract Objective We aimed to develop an early warning system for real-time sepsis prediction in the ICU by equipping with interpretation analysis and transfer learning tools improve feasibility deploy system, particularly target cohorts. Design Retrospective observational study. Setting Medical Information Mart Intensive Care (MIMIC) dataset, private Historical Database of local Ruijin Hospital (HDRJH), data collected from real-world Patients 6891 patients MIMIC dataset 453 HDRJH model...
Abstract Background The lack of information interoperability between different devices and systems in the ICU hinders further utilization data, especially for early warning specific diseases ICU. Objectives We aimed to establish a real-time system sepsis based on data integration that can be implemented at bedside intensive care unit (ICU), named SEPRES. Methods Data is collected from through hub uploaded local area network. was designed integrate vital signs laboratory ventilator...
Abstract Background The lack of information interoperability between different devices and systems in the intensive care unit (ICU) hinders further utilization data, especially for early warning specific diseases ICU. Objectives We aimed to establish a data integration system. Based on this system, sepsis prediction module was added compose Sepsis PREdiction System (SEPRES), where real-time can be implemented at bedside Methods Data are collected from through hub uploaded system local area...
Abstract Understanding the cross-cultural differences in emotion perception has captured interest of researchers for decades. While various mechanisms have emerged to explain such differences, general inclination differentiate emotions, irrespective whether they relate others or oneself, remained unclear. To investigate this overarching propensity, we selected Toronto Alexithymia Scale (TAS-20) as a suitable instrument measuring extent which individuals typically recognize and describe their...