A5103271524- Distributed systems and fault tolerance
- Salmonella and Campylobacter epidemiology
- Integrated Circuits and Semiconductor Failure Analysis
- Parallel Computing and Optimization Techniques
- VLSI and Analog Circuit Testing
- Distributed and Parallel Computing Systems
- Advanced Data Storage Technologies
- Coding theory and cryptography
- Autophagy in Disease and Therapy
- Cryptography and Residue Arithmetic
- Rheumatoid Arthritis Research and Therapies
- Software System Performance and Reliability
- Microbial infections and disease research
- Advanced Database Systems and Queries
- Viral gastroenteritis research and epidemiology
- Hydrocarbon exploration and reservoir analysis
- Non-Destructive Testing Techniques
- Mast cells and histamine
- Low-power high-performance VLSI design
- Animal Behavior and Welfare Studies
- Orthopaedic implants and arthroplasty
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Electrostatic Discharge in Electronics
- Ultrasonics and Acoustic Wave Propagation
Cedars-Sinai Medical Center
2015-2024
Cedars-Sinai Smidt Heart Institute
2015-2024
University of Miami
2022
University of British Columbia
2021
Royal Adelaide Hospital
1996-2020
Sinai Hospital
2017
University of York
2009-2014
University of Waterloo
1996-2013
University of Glasgow
2003-2012
Toronto Metropolitan University
2012
Myogenesis is a crucial process governing skeletal muscle development and homeostasis. Differentiation of primitive myoblasts into mature myotubes requires metabolic switch to support the increased energetic demand contractile muscle. Skeletal specifically shift from highly glycolytic state relying predominantly on oxidative phosphorylation (OXPHOS) upon differentiation. We have found that this phenomenon dramatic remodeling mitochondrial network involving both clearance biogenesis. During...
The role of p38 mitogen-activated protein kinase (MAPK) in responses human fibroblasts and vascular endothelial cells to IL-1 was investigated by use a pyridinyl imidazole compound (SB 203580), which specifically inhibits the enzyme. SB 203580 inhibited (50% inhibitory concentration approximately 0.5 microM) IL-1-induced phosphorylation heat shock 27 (an indicator MAPK activity) without affecting other known IL-1-activated pathways (p42/p44 MAPK, p54 MAPK/c-Jun N-terminal beta-casein...
Non-alterable identification is required for tracking work in progress, detecting part rebranding, radio frequency (RFID), IP protection, and transaction validation. Wafer-level techniques such as laser link cutting, circuit-level EPROM techniques, require expensive machinery or special wafer processing. Integrated circuit (ICID) extracts unique repeatable information from the randomness inherent silicon No external programming process steps are needed, technique may be used with any...
Mast cell activation in vivo is often associated with areas of oedema and connective‐tissue degradation. Tryptase chymase are the major serine proteinases released by mast cells, but they appear to have little activity on most components extracellular matrix. The matrix metalloproteinases (MMP) purported degrade almost all connective tissue elements secreted cells form inactive precursors. Since mechanisms MMP poorly understood we examined potential activate precursor forms human collagenase...
This paper proposes the use of multiple sensors in pulsed eddy-current detection for three-dimensional (3-D) subsurface flaw imaging. A normalization technique has been proposed to eliminate characteristic variation among Hall devices used probe and lift off effects. principal component analysis-based feature extraction that provides orthogonal information sensor fusion introduced investigated. Using features projection coefficients, 3-D surface flaws can be measured reconstructed. The...
Genetic deficiency of dystrophin leads to disability and premature death in Duchenne muscular dystrophy (DMD), affecting the heart as well skeletal muscle. Here, we report that clinical-stage cardiac progenitor cells, known cardiosphere-derived cells (CDCs), improve myopathy mdx mouse model DMD. Injection CDCs into hearts mice augments function, ambulatory capacity, survival. Exosomes secreted by human reproduce benefits induced pluripotent stem cell-derived cardiomyocytes. Surprisingly,...
A new single-crystal diffraction facility has been constructed on beamline 9 of the SRS at Daresbury Laboratory for study structural problems in chemistry and materials science. The station utilizes up to 3.8 mrad horizontally from 5 T wiggler magnet which can be focused vertically. horizontal focusing is provided by a choice gallium-cooled triangular bent Si (111) or (220) monochromators, giving wavelength range 0.3 1.5 Å. Focusing vertical plane achieved cylindrically zerodur mirror with...
In this paper an algorithm for GF(2/sup m/) multiplication/division is presented and a new, more generalized definition of duality proposed. From these the bit-serial Berlekamp multiplier derived shown to be specific case general class multipliers. Furthermore, it that hardware efficient, bit-parallel dual basis multipliers can also designed. These have regular structure, are easily extended different hence suitable VLSI implementations. As in hardwired carry out constant multiplication....
The increasing cost of computer system failure has stimulated interest in improving software reliability. One way to do this is by adding redundant structural data structures. Such redundancy can be used detect and correct (structural) errors instances a structure. intuitive approach paper, which makes heavy use examples, complemented the more formal development companion "Redundancy Data Structures: Some Theoretical Results."
Mitophagy occurs during ischemia/reperfusion (I/R) and limits oxidative stress injury. Mitochondrial turnover was assessed in patients undergoing cardiac surgery involving cardiopulmonary bypass (CPB). Paired biopsies of right atrial appendage before initiation after weaning from CPB were processed for protein analysis, mitochondrial DNA/nuclear DNA ratio (mtDNA:nucDNA ratio), mtDNA damage, mRNA, polysome profiling. the post-CPB samples evidenced by decreased levels mitophagy adapters NDP52...
In the United Kingdom there has been a marked increase in number of human infections caused by toxigenic Corynebacterium ulcerans. During 2002 and 2003 organism was also isolated from several domestic cats with bilateral nasal discharge. As C. ulcerans never previously cats, 16S rRNA gene three cat isolates sequenced to confirm their species identities. Fifty clinical 1986 seven were characterized ribotyping determine whether ribotypes genotypically related those found for isolates. For...
Recent studies with viral oncogene tyrosine kinases have suggested that these may phosphorylate phosphoinositides and diacylglycerol.Since the receptors for insulin epidermal growth factor (EGF) also possess kinase activity, we investigated possible effects of EGF on phosphoinositide metabolism in rat liver plasma membranes hepatocytes.In prepared from rats injected 18 h prior [SH]rnyo-inositol or incubated [y32P]ATP, phosphatidylinositol-4-P phosphatidylinositol-4,5-P~ were formed, but...
Background: Bone marrow lesions (BMLs) are useful diagnostic and prognostic markers in knee osteoarthritis (OA), but what they represent at the tissue level remains unclear.The aim of this study was to provide comprehensive characterization BMLs detected using two specific MRI sequences.Methods: Tibial plateaus were obtained from 60 patients (29 females, 31 males), undergoing arthroplasty for OA.To identify BMLs, performed ex vivo T1 PDFS-weighted sequences.Multi-modal analyses osteochondral...
Preservation of mitochondrial function, which is dependent on homeostasis (biogenesis, dynamics, disposal/recycling), critical for maintenance skeletal muscle function.Skeletal performance declines upon aging (sarcopenia) and accompanied by decreased function in fastglycolytic muscles.Oxidative metabolism promotes homeostasis, so we investigated whether preserved oxidative muscles.We compared tibialis anterior (predominantly glycolytic) soleus (oxidative) muscles from young (3 mo) old (28-29...
Browning of white adipose tissue (WAT) promotes increased energy expenditure through the action uncoupling protein 1 (UCP1) and is an attractive target to promote weight loss in obesity. Lowering mitochondrial membrane potential by UCP1 uniquely beneficial this context; other tissues, reduced clearance via mitophagy. It unknown how parkin-mediated mitophagy regulated beige adipocytes.The relationship between parkin expression WAT browning was investigated 3T3-L1 adipocytes parkin-deficient...
Sodium–glucose cotransporter 2 (SGLT2) inhibitors such as empagliflozin are known to reduce the risk of hospitalizations related heart failure irrespective diabetic state. Meanwhile, adverse cardiac remodeling remains leading cause and death in USA. Thus, understanding mechanisms that responsible for beneficial effects SGLT2 is utmost relevance importance. Our previous work illustrated a connection between regulation mitochondrial turnover cellular energetics using short-acting glucagon-like...