A5058834240- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Graphene and Nanomaterials Applications
- Wound Healing and Treatments
- Tissue Engineering and Regenerative Medicine
- Nanoplatforms for cancer theranostics
- Immune cells in cancer
- Freezing and Crystallization Processes
- Bone and Dental Protein Studies
- biodegradable polymer synthesis and properties
- 3D Printing in Biomedical Research
- Spine and Intervertebral Disc Pathology
- Bone health and osteoporosis research
- Synthesis and Catalytic Reactions
- Mesenchymal stem cell research
- Satellite Communication Systems
- Membrane Separation Technologies
- Dental Implant Techniques and Outcomes
- Bone Metabolism and Diseases
- Cyclopropane Reaction Mechanisms
- Thermochemical Biomass Conversion Processes
- Cellular Mechanics and Interactions
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Facial Trauma and Fracture Management
Griffith University
2023-2025
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2024
Shanghai University of Traditional Chinese Medicine
2024
Xidian University
2022-2024
Queensland University of Technology
2021-2023
First Affiliated Hospital of Henan University
2023
South China University of Technology
2017-2022
National Research Center for Rehabilitation Technical Aids
2017-2022
Guangzhou Medical University
2021-2022
Stomatology Hospital
2021-2022
Treatment of diabetic wounds with a rapid healing performance remains critical clinical challenge. An extracellular matrix (ECM)-biomimetic structure has shown promise in promoting tissue regeneration through mediating cellular microenvironment. Herein, we report bone ECM-biomimetic cell-free nanofibrous scaffolds for enhancing full-thickness wounds. This bioactive was composed ECM-componential collagen (Col, mimicking protein), polycaprolactone (PCL), and glass nanoparticles (BGNs,...
We fabricated biomimetic nanofibrous scaffolds with crossed fiber organization, which possess the potential utility for chronic wound repair.
Novel sonosensitizers with intrinsic characteristics for tumor diagnosis, efficient therapy, and microenvironment regulation are appealing in current sonodynamic therapy. Herein, a manganese (Mn)-layered double hydroxide-based defect-rich nanoplatform is presented as new type of sono-chemo sensitizer, which allows ultrasound to efficiently trigger reactive oxygen species generation enhanced sono/chemo-dynamic Moreover, such able relieve hypoxia achieve augmented singlet production via...
Direct hypoxia alleviation and lactate depletion in the tumor microenvironment (TME) are promising for effective cancer therapy but still very challenging. To address this challenge, current research directly reshapes TME inhibiting growth activating antitumor immunity using a drug-free nanozyme. Herein, acid-sensitive nanozymes were constructed based on peroxidized layered double hydroxide nanoparticles O2 self-supply self-boosted depletion. The coloading of partially cross-linked catalase...
DMOG-loaded nanofibrous wound dressings enhanced diabetic healing by stabilizing HIF-1α.
Abstract Bioactive glass (BG) can repair bone defects, however, it is not clear whether BG has the ability for augmentation without making any defect. Unlike intramembranous osteogenesis in defect repair, extramembranous occurs outside cortical and osteoprogenitor cells show reversed migration. Herein, nanoscale bioactive scaffolds (BGSs) are fabricated, their role immunomodulation‐related mechanism investigated. The vitro migration differentiation of calvaria preosteoblasts studied by...
Constructing the interconnected porous biomaterials scaffolds with osteogenesis and angiogenesis capacity is extremely important for efficient bone tissue engineering. Herein, we fabricated a bioactive micro-nano composite excellent in vitro capacity, based on poly (lactic-co-glycolic acid) (PLGA) incorporated glass (MNBG). The results showed that addition of MNBG enlarged pore size, increased compressive modulus (4 times improvement), enhanced physiological stability apatite-forming ability...
Mesenchymal stem cells (MSCs) have broad therapeutic potential due to their ability secrete bioactive factors that are immunomodulatory and trophic (regenerative). In this study, polyacrylamide (PAAm) hydrogels with different stiffness used as a model explore the effects of substrate on paracrine function human mesenchymal (hMSCs). Human MSCs cultured soft substrates produced significantly higher levels compared hMSCs rigid substrates. The enhanced is further confirmed by M2 phenotypic...
Strontium-substituted bioactive glass (Sr-BG) has shown superior performance in bone regeneration. Sr-BG-induced osteogenesis been extensively studied; however, Sr-BG-mediated osteoclastogenesis and the underlying molecular mechanism remain unclear. It is recognized that balance of closely related to repair, receptor activators nuclear factor kappaB ligand (RANKL) signaling pathway plays a key role regulation osteoclastogenesis. Herein, we studied potential impact underling...
Numerous studies have shown that scaffolds incorporated with extracellular matrix (ECM) proteins could regulate cell behaviors and improve wound healing. However, most ECM-containing fail to capture the dynamic features of native ECM. In this regard, nanofibrous which mimic composition transition ECM during healing may great potential in promoting skin regeneration through dynamically modulating microenvironment. Herein, we report a novel ECM-biomimetic coaxial scaffold for repair chronic...
Biomineralization is a process that leads to the formation of hierarchically arranged structures in mineralized tissues, such as bone and teeth. Extensive research has been conducted on crystals bones teeth, with aim understanding underlying mechanisms mineralization process. Pathological/ectopic mineralization, kidney stones, calcific tendinitis, skeletal fluorosis, shares some similar features but different physiological mineralization. A better will provide new perspectives for treating...
Mesoporous bioactive glass (MBG) is a type of material with high biological activity and excellent biocompatibility. Because its specific surface area adjustable morphology, MBG usable for loading delivering molecules. In our previous report, particles were used as gene vectors showed good transfection rate. this paper, MBG, prepared through sacrificial liquid template method in sol–gel process, was covered polyglycerol (PG) the resulting MBG-PG further functionalized octaarginine (Arg8....