A5102829241- Oral microbiology and periodontitis research
- Endodontics and Root Canal Treatments
- Infective Endocarditis Diagnosis and Management
- Streptococcal Infections and Treatments
- Respiratory viral infections research
- Bacterial biofilms and quorum sensing
- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Animal Virus Infections Studies
- Dental materials and restorations
- Diet, Metabolism, and Disease
- Antimicrobial Resistance in Staphylococcus
- Diet and metabolism studies
- Lipoproteins and Cardiovascular Health
- vaccines and immunoinformatics approaches
- Food composition and properties
- Ammonia Synthesis and Nitrogen Reduction
- Dental Erosion and Treatment
- Viral gastroenteritis research and epidemiology
- Anesthesia and Sedative Agents
- Salivary Gland Disorders and Functions
- Nausea and vomiting management
- Luminescence Properties of Advanced Materials
- Education and Learning Interventions
- Influenza Virus Research Studies
La Jolla Institute for Immunology
2024
University of Waterloo
2024
Seoul National University
2013-2022
Korea Advanced Institute of Science and Technology
2015-2022
Seoul National University Dental Hospital
2019-2021
Wonkwang University
2020
Sookmyung Women's University
2019
National Cancer Center
2019
Daegu University
2018
Korea University
2017
More than half of the adult population worldwide is overweight or obese, while excess adiposity has been linked to chronic low-grade inflammation, contributing development diseases. Recent studies have showed that diet-induced alterations gut microbiota composition play a pivotal role in obesity. However, cause-effect relationship between obesity and not yet fully understood. In this study, we investigated short-term responses diets with different fat contents their associations inflammatory...
Sessile hydrogel drops on rigid surfaces exhibit a wetting/contact morphology intermediate between liquid and glass spheres. Using density functional theory, we reveal the contact forces acting surface. We show that while transitioning from liquid-like to solid-like hydrogels, there exists critical elasticity enables switch attractive-to-repulsive interaction with underlying Our theoretical model is validated by experimental observations of sessile polyacrylamide hydrogels varying surfaces....
Microglial activation has been implicated in many neurological disorders for its inflammatory and neurotrophic effects. In this study, we investigated the pharmaceutical properties of 6,6'-bieckol on regulation nuclear factor-κB (NF-κB) responsible to expression inducible nitric oxide synthase (iNOS) cyclooxygenase (COX)-2 using lipopolysaccharide (LPS)-stimulated BV2 murine primary microglial cells. Meterials methods: The levels (NO), prostaglandin E2 (PGE)2, pro-inflammatory cytokines were...
The tumor immune microenvironment (TIME) in high-grade glioma (HGG) exhibits high spatial heterogeneity. Though the core and peripheral regions have different biological features, cause of this heterogeneity has not been clearly elucidated. Here, we examined HGG using obtained separately from patients with HGG. We analyzed infiltrating cells by flow cytometry 34 transcriptomes RNA-seq analysis 18 Peripheral region-infiltrating were vitro cultured hypoxic conditions their immunophenotypes...
Staphylococcus aureus is a major pathogen that causes various diseases including skin and soft tissue infections, pneumonia, gastroenteritis, sepsis. Antibiotic-resistant S. such as methicillin-resistant (MRSA) multidrug-resistant serious threat in healthcare-associated settings the communities. In this study, we investigated effects of short-chain fatty acids, metabolites produced by commensal bacteria, on growth both vitro vivo. Sodium propionate (NaP) most potently inhibited MRSA clinical...
Summary Frequent recent spillovers of subtype H5N1 clade 2.3.4.4b highly pathogenic avian influenza (HPAI) virus into poultry and mammals, especially dairy cattle, including several human cases, increased concerns over a possible future pandemic. Here, we performed an analysis epitope data curated in the Immune Epitope Database (IEDB). We found that patterns immunodominance seasonal viruses circulating humans are similar. further conclude significant fraction T cell epitopes is conserved at...
ABSTRACT Frequent recent spillovers of subtype H5N1 clade 2.3.4.4b highly pathogenic avian influenza (HPAI) virus into poultry and mammals, especially dairy cattle, including several human cases, increased concerns over a possible future pandemic. Here, we performed an analysis epitope data curated in the Immune Epitope Database (IEDB). We found that patterns immunodominance seasonal viruses circulating humans are similar. further conclude significant fraction T-cell epitopes is conserved at...
Skeletal muscle atrophy is one of the major symptoms cancer cachexia. Garlic (Allium sativum), world’s most commonly used and versatile herbs, has been employed for prevention treatment diverse diseases centuries. In present study, we found that ajoene, a sulfur compound in crushed garlic, exhibits protective effects against atrophy. Using CT26 tumor-bearing BALB/c mice, demonstrate vivo ajoene extract alleviated degradation by decreasing not only myokines secretion but also janus...
본 연구는 시판중인 에너지음료에 의한 치아 법랑질 침식효과를 알아보기 위하여 선호도가 높은 4종의 에너지음료를 선정하여 산도, 완충능 및 Ca, P 함량을 분석하였다. 또한 에너지음료 침지 전 후의 법랑질의 침식 정도를 표면미세경도와 SEM으로 관찰하여 다음과 같은 결론을 얻었다. 1. 에너지음료의 산성도는 번인텐스에서 <TEX>$2.78{\pm}0.01$</TEX>로 가장 낮았고 대조군인 증류수에서 <TEX>$6.475{\pm}0.01$</TEX>로 높았다. 완충능은 번인텐스가 pH 5.5에서 <TEX>$3.48{\pm}0.155$</TEX>이고, 7.0에서는 <TEX>$1.88{\pm}0.15$</TEX>로 높게 나타났고, 핫식스에서 각각 <TEX>$1.71{\pm}0.37$</TEX>, <TEX>$1.23{\pm}0.35$</TEX>로 낮게 나타났다. 2. 칼슘 함유량은 레드불(<TEX>$77.21{\pm}2.70mg/kg$</TEX>)에서 나타났고...
This study aimed to justify the use of contingent valuation method elicit willingness pay (WTP) for counselling services and analyse socio-demographic psychological factors that influence WTP (through an increase in insurance premiums) South Korea. Regarding services, researchers asked 561 participants double-bounded dichotomous choice questions, which is one major estimation methods. Two survival analysis models were set up with their corresponding variables investigate affecting premiums...
Initiation and progression of oral infectious diseases are associated with streptococcal species. Bacterial infection induces inflammatory responses together reactive oxygen species (ROS), often causing cell death tissue damage in the host. In present study, we investigated effects streptococci on cytotoxicity ROS production human periodontal ligament (PDL) cells. Streptococcus gordonii showed a dose- time-dependent manner. The might be due to apoptosis since S. increased annexin V-positive...