A5034757688- Glioma Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- Radiomics and Machine Learning in Medical Imaging
- Neurofibromatosis and Schwannoma Cases
- Medical Imaging and Analysis
- Augmented Reality Applications
- Surgical Simulation and Training
- Bone Tumor Diagnosis and Treatments
- Brain Metastases and Treatment
- Intraoperative Neuromonitoring and Anesthetic Effects
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Spinal Fractures and Fixation Techniques
- Anatomy and Medical Technology
- Musculoskeletal synovial abnormalities and treatments
- Cerebrospinal fluid and hydrocephalus
- Brain Tumor Detection and Classification
- Robotics and Sensor-Based Localization
- Single-cell and spatial transcriptomics
- Cell Image Analysis Techniques
- Vascular Malformations Diagnosis and Treatment
- Orthopedic Surgery and Rehabilitation
- Advanced Radiotherapy Techniques
Seoul National University Bundang Hospital
2023-2025
Seoul National University
2021-2025
Seoul National University Hospital
2016-2024
National University College
2021-2024
New Generation University College
2021-2024
Kookmin University
2024
University of Colorado System
2021
University of Colorado Boulder
2021
Lieber Institute for Brain Development
2021
Chonnam National University Hwasun Hospital
2012
Abstract The usefulness of 3-dimensional (3D)-printed disease models has been recognized in various medical fields. This study aims to introduce a production platform for patient-specific 3D-printed brain tumor model clinical practice and evaluate its effectiveness. A full-cycle was created the application (3D-printed model) system. Essential elements included automated segmentation software, cloud-based interactive communication tools, customized with exquisite expression anatomy...
Background Accurate and rapid measurement of the MRI volume meningiomas is essential in clinical practice to determine growth rate tumor. Imperfect automation disappointing performance for small previous automated volumetric tools limit their use routine practice. Purpose To develop validate a computational model fully meningioma segmentation on contrast‐enhanced scans using deep learning. Study Type Retrospective. Population A total 659 intracranial patients (median age, 59.0 years;...
The tumor immune microenvironment (TIME) in high-grade glioma (HGG) exhibits high spatial heterogeneity. Though the core and peripheral regions have different biological features, cause of this heterogeneity has not been clearly elucidated. Here, we examined HGG using obtained separately from patients with HGG. We analyzed infiltrating cells by flow cytometry 34 transcriptomes RNA-seq analysis 18 Peripheral region-infiltrating were vitro cultured hypoxic conditions their immunophenotypes...
We report retrospective and prospective studies to identify the causes of fracture femoral neck associated with shaft nailing on same side. Of a total 14 fractures in series 152 nailings, eight were not visible initial pelvic radiographs. used CT scans before after operation, fluoroscopy during procedure our series, reviewed abdominal retrospectively window set bone level. Six undisplaced shown have been present but two iatrogenic. recommend preoperative use high-risk patients such as those...
PurposeThe purpose of this study was to determine the epidemiologic characteristics and survival patients with primary brain other central nervous system (CNS) tumors in Korea compare our findings those from United States.Materials MethodsWe collected data on CNS diagnosed between 2007 2016 Central Cancer Registry. The age-standardized incidence rates (ASRs) 5-year relative (RSRs) were evaluated. We applied classification definitions Brain Tumor Registry States analysis for direct comparison...
The activation of the telomere maintenance mechanism (TMM) is one critical drivers cancer cell immortality. In gliomas, TERT expression and promoter mutation are considered to reliably indicate telomerase activation, while ATRX and/or loss indicates an alternative lengthening telomeres (ALT). However, these relationships have not been extensively validated in tumor tissues.
Mucin 1 (MUC1) is a transmembrane glycoprotein involved in tumorigenesis of diverse cancers. However, the role MUC1 glioblastoma (GBM) has not yet been fully explored. In this study, anticancer mechanism suppression GBM was investigated. The expression level analyzed human glioma and paired normal brain tissues. overexpressed negatively associated with overall survival. Moreover, we silenced to investigate its effect cell lines found that knockdown inhibited proliferation resulted cycle...
OBJECTIVE With the advancement of 3D modeling techniques and visualization devices, augmented reality (AR)–based navigation (AR navigation) is being developed actively. The authors a pilot model their newly inside-out tracking AR system. METHODS technique was based on visual inertial odometry (VIO) algorithm. Quick Response (QR) marker created used for image feature–detection Inside-out works through steps device recognition, implementation, registration within running environment. A virtual...
Objective The skull base reconstruction step, which prevents cerebrospinal fluid (CSF) leakage, is one of the most challenging steps in endoscopic surgery (ESS). purpose this study was to assess outcomes and complications a technique for immediate CSF leakage repair using multiple onlay grafts following ESS. Methods A total 230 consecutive patients who underwent with fibrin sealant patch (FSP), hydroxyapatite cement (HAC), pedicled nasoseptal flap (PNF) high-flow ESS at three institutions...
Primary CNS tumors (PCNSTs) are originating from the brain and surrounding tissues. These account for a significant proportion of cancer deaths morbidity globally. Accurate epidemiologic data essential shaping clinical practices, research priorities, health care policies. This study presents latest 2020 national on PCNSTs Republic Korea (ROK) explores trends in incidence their societal implications context an aging population.
The mechanism of hearing loss following stereotactic radiosurgery (SRS) for vestibular schwannomas (VSs) remains unclear. There is conflicting evidence regarding cochlear nerve damage by transient volume expansion VSs after and radiation-induced damage. This study aimed to investigate whether there a specific patient population that can achieve definite preservation SRS VSs.
Abstract We explored the genomic events underlying central neurocytoma (CN), a rare neoplasm of nervous system, via multiomics approaches, including whole-exome sequencing, bulk and single-nuclei RNA methylation sequencing. identified FGFR3 hypomethylation leading to overexpression as major event in ontogeny CN that affects crucial downstream events, such aberrant PI3K-AKT activity neuronal development pathways. Furthermore, we found similarities between radial glial cells based on analyses...
The prognostic nutritional index (PNI) reflects immunonutritional status. We evaluated the effects of postoperative PNI and perioperative changes in on overall survival (OS) glioblastoma (GBM) patients.Demographic, laboratory, clinical data were retrospectively collected from 335 GBM patients. Preoperative PNIs calculated serum albumin concentration lymphocyte count, which measured within 3 weeks before surgery 1 month after surgery. Patients classified into high (n = 206) or low 129) groups...
Abstract Alu is a primate-specific repeat element in the human genome and has been increasingly appreciated as regulatory many biological processes. But appreciation of limited tumorigenesis, especially for brain tumor. To investigate relevance to gliomagenesis, we studied element-associated post-transcriptional processes RNA expression by performing RNA-seq total 41 pairs neurotypical diverse glioma tissues. We find that A-to-I editing circular levels, well expression, are decreased overall...
Abstract Augmented reality (AR) offers a new medical treatment approach. We aimed to evaluate frameless (mask) fixation navigation using 3D-printed patient model with fixed-AR technology for gamma knife radiosurgery (GKRS). Fixed-AR was developed the inside-out method visual inertial odometry algorithms, and flexible Quick Response marker created object-feature recognition. Virtual 3D-patient models AR-rendering were via 3D-scanning utilizing TrueDepth cone-beam computed tomography (CBCT)...
Functional magnetic resonance imaging (fMRI) and diffusion tensor imaging-derived tractography (DTI-t) contribute to the localization of language areas, but their accuracy remains controversial. This study aimed investigate diagnostic performance preoperative fMRI DTI-t obtained with a simultaneous multi-slice technique using intraoperative direct cortical stimulation (DCS) or corticocortical evoked potential (CCEP) as reference standards.This prospective included 26 patients (23-74 years;...
Although limb salvage surgery for primary sarcoma of the upper is a standard procedure, it often technically challenging. We asked whether segmental resection and replantation would provide (1) local control long-term survival (2) useful function in patients who had advanced malignant aggressive tumors limbs. retrospectively reviewed six treated with this procedure when wide around tumor could not be achieved other limb-salvage procedures. Diagnoses included osteosarcoma (two), Ewing's...