A5046513306- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- Vascular Malformations Diagnosis and Treatment
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Trigeminal Neuralgia and Treatments
- Nausea and vomiting management
- Nanoplatforms for cancer theranostics
- Intraoperative Neuromonitoring and Anesthetic Effects
- Anesthesia and Pain Management
- CAR-T cell therapy research
- Facial Nerve Paralysis Treatment and Research
- Facial Trauma and Fracture Management
- Traumatic Ocular and Foreign Body Injuries
- Nasal Surgery and Airway Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Cerebrospinal fluid and hydrocephalus
- Advanced Radiotherapy Techniques
- Pituitary Gland Disorders and Treatments
- PARP inhibition in cancer therapy
- Spinal Dysraphism and Malformations
- Advanced Neuroimaging Techniques and Applications
- Lung Cancer Research Studies
- Anatomy and Medical Technology
Seoul National University Bundang Hospital
2020-2025
Weifang Medical University
2025
Seoul National University
2021-2024
Seoul National University Hospital
2019-2020
National University College
2020
New Generation University College
2020
Abstract The usefulness of 3-dimensional (3D)-printed disease models has been recognized in various medical fields. This study aims to introduce a production platform for patient-specific 3D-printed brain tumor model clinical practice and evaluate its effectiveness. A full-cycle was created the application (3D-printed model) system. Essential elements included automated segmentation software, cloud-based interactive communication tools, customized with exquisite expression anatomy...
Zygoma is a major buttress of the midfacial skeleton, which frequently injured because its prominent location. fractures are classified according to Knight and North based on direction anatomic displacement pattern created by fracture. In zygomaticomaxillary complex (ZMC) fracture many incisions (lateral eyebrow, lateral upper blepharoplasty, transconjunctival, subciliary, subtarsal, intraoral, direct percutaneous approach) useful. We reviewed various approaches for treatment ZMC discussed...
Background Numerous studies reported a usefulness of 5-aminolevulinic acid (5-ALA) fluorescence-guided surgery (FGS) in high grade gliomas.However, fluorescence patterns and intensities are variable among gliomas.In this study, we report our extensive experience with FGS various gliomas, focusing on epidemiological data patterns. MethodsA total 827 histologically proven glioma patients out 900 brain tumor who had undergone using 5-ALA during the period 8.5 years between July 2010 January...
The mechanism of hearing loss following stereotactic radiosurgery (SRS) for vestibular schwannomas (VSs) remains unclear. There is conflicting evidence regarding cochlear nerve damage by transient volume expansion VSs after and radiation-induced damage. This study aimed to investigate whether there a specific patient population that can achieve definite preservation SRS VSs.
Abstract We explored the genomic events underlying central neurocytoma (CN), a rare neoplasm of nervous system, via multiomics approaches, including whole-exome sequencing, bulk and single-nuclei RNA methylation sequencing. identified FGFR3 hypomethylation leading to overexpression as major event in ontogeny CN that affects crucial downstream events, such aberrant PI3K-AKT activity neuronal development pathways. Furthermore, we found similarities between radial glial cells based on analyses...
Abstract Background Given the typical trajectory of glioblastoma, many patients lose decision-making capacity over time, which can lead to inadequate advance care planning (ACP) and end-of-life (EOL) care. We aimed evaluate patients’ current ACP EOL status. Patients Methods conducted a cohort study on 205 referred oncologists at Korean tertiary hospital between 2017 2022. collected information sociodemographic factors, cancer treatment, palliative consultation, ACP, legal documents...
An optimal radiological surveillance plan is crucial for high-grade glioma (HGG) patients, which determined arbitrarily in daily clinical practice. We propose the assessment schedule using a parametric model of standardized progression-free survival (PFS) curves.A total 277 HGG patients (178 glioblastoma [GBM] and 99 anaplastic astrocytoma [AA]) from single institute who completed standard treatment protocol were enrolled this cohort study retrospectively analyzed. The stratified into each...
Background/Aim: Poly (ADP-ribose) polymerase (PARP) inhibition could enhance the efficacy of temozolomide and prolong survival in patients with glioblastoma. The aim this study was to evaluate combination PARP inhibitor olaparib treatment Materials Methods: vitro vivo antitumor effects together were evaluated. experimental glioblastoma model involved O<sup>6</sup>-methylguanine methyltransferase (MGMT) promoter-methylated (U87MG, U251MG) MGMT promoter-unmethylated (T98G) cell lines using In...
Background Only sporadic reports of fluorescence-guided surgery (FGS) have been published for non-glioma conditions.In this study, we focus on epidemiological data fluorescence patterns and report the diverse experiences FGS in non-gliomas. MethodsDuring 8.5 years between July 2010 January 2019, 900 brain tumor performed Seoul National University Hospital.Among them, a total 73 histologically proven nonglioma patients were analyzed.Indications possibility anaplastic intra-axial tumors...
Functional magnetic resonance imaging (fMRI) and diffusion tensor imaging-derived tractography (DTI-t) contribute to the localization of language areas, but their accuracy remains controversial. This study aimed investigate diagnostic performance preoperative fMRI DTI-t obtained with a simultaneous multi-slice technique using intraoperative direct cortical stimulation (DCS) or corticocortical evoked potential (CCEP) as reference standards.This prospective included 26 patients (23-74 years;...
OBJECTIVE Postoperative nausea and vomiting (PONV) occurs frequently after microvascular decompression (MVD). Fentanyl, an opioid, is strongly related to the development of PONV, ketorolac, a nonsteroidal anti-inflammatory drug, has been approved for postoperative pain management. However, how ketorolac-based patient-controlled analgesia (PCA) causes PONV or its efficacy differs from that fentanyl-based PCA MVD unclear. In this study, authors compared with in terms incidence severity MVD....
Abstract The natural growth pattern of vestibular schwannoma (VS) associated with the rare disease neurofibromatosis type 2 (NF2) has not been sufficiently elucidated, and rationale for proactive treatment VS in NF2 is firmly established. This study aimed to uncover identify risk factors rapid growth. A total 68 VSs from 41 patients who were diagnosed Seoul National University Bundang Hospital July 2006 2023 retrospectively reviewed. was clinically according Manchester criteria. mean age...
Abstract We report a case of glioneuronal tumor (GNT) with discovery novel gene fusion CLIP2-MET resulting from aberrant chromosome 7 abnormalities. executed an elaborate genomic study on this including whole-exome sequencing and RNA sequencing. Genomic analysis the revealed aberrations in chromosomes 1 fusion. Further upregulated genes substantial connections MAPK pathway activation. concluded that abnormalities prompted which successively leads to deliberated activation is one driver...
Metaplastic meningioma is an extremely rare subtype of World Health Organization (WHO) grade I meningioma. It has distinctive histological subtypes according to its own mesenchymal components. Owing scarcity, clinical or radiological features a metaplastic are poorly described.Between 2004 and 2018, we analyzed total 1814 cases surgically proven for 15 years. Among them, was diagnosed in 11 cases. Magnetic resonance images were taken all patients, computed tomography scan 10 patients.WHO...
Rathke's cleft cysts (RCCs) are nonneoplastic cysts. Most of them asymptomatic and stable; when symptomatic, RCCs surgically fenestrated drained. However, the outcomes remain unclear. The authors evaluated RCC decompression.Between 2004 2019, 32 were decompressed in a single tertiary institution. clinical characteristics, intraoperative findings, postoperative complications, endocrinological surgical retrospectively reviewed. Patients who underwent sequential imaging at least twice 12 months...
OBJECTIVE The lateral spread response (LSR) is an aberrant electrophysiological in which a stimulus on one branch of the facial nerve spills over to other branches nerve, can be captured by electrodes near each branch. authors performed this study evaluate prognostic value follow-up LSR with sufficient time interval from intraoperative (IO-LSR) after microvascular decompression (MVD) for hemifacial spasm (HFS), excluding interference various situations. METHODS A total 247 patients treated...
Infection is the most serious complication after rhinoplasty, with rates reported to range from 2.6% 5.3% [[1]]. In that study, infections were found be localized and improved removal of implant appropriate antibiotic therapy. Although a case report has described staphylococcal spinal osteomyelitis septoplasty as consequence bacteremia [[2]], no sepsis resulting in death rhinoplasty been reported. We male patient who expired due infection septal extension graft, silicone implant, fat...
Brown syndrome is known as limited elevation of the affected eye during adduction. It caused by a disorder superior oblique tendon, which makes it difficult for eyeball to look upward, especially classified into congenital true sheath and acquired simulated syndrome. Acquired can be trauma, infection, or inflammatory conditions. The surgical restoration blowout fractures also lead limitations ocular motility, including We report on three patients with syndrome, who complained diplopia...
Intraoperative language mapping under general anesthesia is imperative for brain tumor surgery because awake not always feasible. Monitoring corticocortical evoked potential (CCEP) known to be a useful method tracking neuronal connectivity and localizing functional areas. The authors evaluated the clinical benefit of intraoperative CCEP monitoring function preservation in patients undergoing glioma surgery.
Packing after closed reduction of nasal fracture causes uncomfortable obstruction in patients. We packed the superior meatus with synthetic polyurethane foam (SPF) to support bone, and middle a airway splint (NAS) SPF. The aim this article is prospectively compare subjective patient discomfort SPF (Nasopore Forte plus) packing alone NAS.We compared (group A) NAS B) via visual analog scale (VAS; 0, no symptom; 100, most severe symptom).At first postoperative day group B showed significant...
Objective: Rathke's cleft cysts (RCCs) are nonneoplastic cysts. Most of them asymptomatic and stable; when symptomatic, RCCs surgically fenestrated drained. However, the outcomes remain unclear. The authors evaluated RCC decompression.