A5089686159- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Sulfur Compounds in Biology
- Photochromic and Fluorescence Chemistry
- Nanoparticle-Based Drug Delivery
- Photodynamic Therapy Research Studies
- Advanced Nanomaterials in Catalysis
- Computational Drug Discovery Methods
- Nicotinic Acetylcholine Receptors Study
- Lanthanide and Transition Metal Complexes
- Cholinesterase and Neurodegenerative Diseases
- Nerve injury and regeneration
- Photochemistry and Electron Transfer Studies
- Crystallization and Solubility Studies
- Hemoglobin structure and function
- Silicon Nanostructures and Photoluminescence
- Ultrasound and Hyperthermia Applications
- Acute Kidney Injury Research
- Analytical Chemistry and Sensors
- Antimicrobial Peptides and Activities
- Folate and B Vitamins Research
- Parkinson's Disease Mechanisms and Treatments
- Covalent Organic Framework Applications
Kyung Hee University
2020-2025
Graduate School USA
2020-2021
Government of the Republic of Korea
2020-2021
Engineering excitation wavelength of photosensitizers (PSs) for enhanced reactive oxygen species (ROS) generation has inspired new windows opportunities, enabling investigation previously impracticable biomedical and photocatalytic applications. However, controlling the corresponding to operating conditions remains challenging while maintaining high ROS generation. To address this challenge, we implement a wavelength-engineerable imidazolium-based porous organic system (KUP system) via...
Acetylcholinesterase (AChE) is an extremely critical hydrolase tightly associated with neurological diseases. Currently, developing specific substrates for imaging AChE activity still remains a great challenge due to the interference from butyrylcholinesterase (BChE) and carboxylesterase (CE). Herein, we propose approach designing detection by combining dimethylcarbamate choline self-immolative scaffold. The representative P10 can effectively eliminate CE BChE. high specificity of has been...
Cervical cancer screening is a crucial field of femtech (female technology). In this work, we disclosed new solution─a simple, straightforward, and on-site applicable urine-based cervical diagnostic method using fluorescent biothiol probe. Our newly developed nitrobenzene-based probe, named NPS-B, effectively differentiates between cysteine homocysteine within urine samples via controlled Smiles rearrangement. The analysis emission-based signals offers the potential utility in cancer. NPS-B...
A fluorescent molecular probe for the identification of glioblastoma is developed. The allows tracing cysteine (Cys) level, which recognized as a new biomarker GBM.
Fluorescence-guided surgery (FSG) is a surgical method to selectively visualize the tumor site using fluorescent materials with instrumental setups in operation rooms. It has been widely used of brain tumors, such as glioblastoma (GBM), which difficult distinguish from normal tissue. Although FSG crucial for GBM surgery, commercially available have shown serious adverse effects. To satisfy clinical demand, we recently reported reaction-based probes based on 4-chloro-7-nitrobenzofurazan (NBD)...
Photodynamic therapy (PDT) has been used to reduce cancerous and precancerous cells via reactive oxygen species (ROS) generation from photosensitizers. Numerous photosensitizers are available today treat a variety of diseases, but their therapeutic efficacy is hindered within the tumor microenvironment, there safety concerns associated with non-specific activation. In this work, we disclosed nano-therapeutic based on in situ activatable nitrobenzene–cysteine–copper(II) nano-complexes (NCCNs)...
Abstract Amino‐single benzene‐based fluorophores (SBBFs) are representative small‐size fluorescent dyes that have an electron push‐pull structure within the benzene core. In this work, a new library of amino‐SBBFs, which trifluoroacetyl moiety at electron‐pushing amine group (named SBBF‐TFA), featuring variety methylamines, dimethylamines, as well acetyl. To explore SBBF‐TFA library, we conducted (i) synthesis, (ii) assessment various photophysical properties in nine different types...
Recent studies suggesting the importance of gut-microbiome in intestinal aggregated alpha synuclein (α-syn) have led to exploration possible role gut-brain axis central nervous system degeneration. Proteus mirabilis (P. mirabilis), a gram-negative facultative anaerobic bacterium, has been linked brain neurodegeneration animal studies. We hypothesised that P. mirabilis-derived virulence factors aggregate α-synuclein and could prompt pathogenesis dopaminergic brain.
The alleviation properties of a Pt-dendrimer nanozyme for GBM metastasis were introduced the first time. biological demonstrated as suppressor migration, invasion, and adhesion.
Fluorescence guided surgery (FGS) has been highlighted in the clinical site for guiding surgical procedures and providing surgeon with a real-time visualization of operating field. FGS is powerful technique precise surgery, particularly tumor resection; however, clinically approved fluorescent dyes have often shown several limitations during FGS, such as non-tumor-targeting, low vivo stability, insufficient emission intensity, blood–brain barrier penetration. In this study, we disclose dye...
We report, for the first time, a new red-emitting hybrid material based on single-benzene-based fluorophore (SBBF) and silica. This robust formulation shows several features, including bright emissions at red wavelength (>600 nm), high scalability (>gram-scale), facile synthesis (one-pot reaction; SBBF formation, hydrolytic condensation, propagation), stability (under different humidity, pH, light), bio-imaging applicability with low cellular toxicity, an antibacterial effect within...
Background. Kidney transplantation is a widely used treatment for end-stage kidney disease. Nevertheless, the incidence of acute injury (AKI) in deceased donors poses potential hazard because it significantly increases risk delayed graft function and potentially exerts an influence on allograft outcome. It crucial to develop diagnostic model capable assessing existence severity AKI renal grafts. However, no suitable markers have been developed thus far. Methods. We evaluated efficacy...
A hybrid composite of silver nanoparticles (AgNPs) and porous silicon microparticles (pSiMPs) was developed applied for the computed tomography (CT) scanning lungs as an image-guided localization agent. We confirmed grafting AgNPs on oxidized pSiMPs template using various analytical equipment, including a electron microscope (SEM), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), energy-dispersive spectroscopy (EDS). The showed high CT contrast intensity (>1000 HU)...