Analyses have been performed, using on-line selected ion flow tube mass spectrometry (SIFT-MS), of the breath three healthy volunteers, as exhaled via mouth and nose also air in oral cavity during hold, each morning over a period one month. Nine trace compounds quantified concentration distributions constructed. Of these compounds, levels acetone, methanol isoprene are same mouth-exhaled nose-exhaled breath; hence, we deduce that totally systemic. The ammonia, ethanol hydrogen cyanide much...

Previous measurements of acetone concentrations in the exhaled breath healthy individuals and small amount comparable data for suffering from diabetes are briefly reviewed as a prelude to presentation new on sporadic wide variations that occur ostensibly individuals. Data also presented which show following ketogenic diet taken by eight their increased up five times over subsequent 6 h. Similarly, six nine when low carbohydrate was two volunteers remained high several days continued. These...

Original on-line measurements of acetone, ammonia and hydrogen cyanide in the exhaled breath several volunteers within age ranges 4-6 years 60-83 are reported compared with previous data on volunteer cohorts covering ages 17-18 20-60 years. The compiled show that a significant statistical increase occurs increasing age, but acetone do not vary greatly age.

Infection by Pseudomonas aeruginosa (PA) is a major cause of morbidity and mortality in patients with cystic fibrosis (CF). Breath analysis could potentially be useful diagnostic such infection, analyses volatile organic compounds (VOCs) emitted from PA cultures are an important part the search for breath markers lung infection. Our pilot experiments using solid‐phase microextraction, SPME gas chromatography/mass spectrometric (GC/MS) produced strains indicated clear presence methyl...

Throughout the development of breath analysis research, there has been interest in how concentrations trace compounds exhaled are related to their ambient inhaled air. In considering this, Phillips introduced concept 'alveolar gradient' and judged that measured volatile organic should be diminished by an amount equal The objective work described this paper was investigate relationship quantitatively. Thus, experiments have carried out which air polluted seven as given below, analysed SIFT-MS...

To characterize the volatile metabolites produced by genotypically diverse strains of Pseudomonas aeruginosa in order to evaluate their potential for use as biomarkers lung infection noninvasive breath analysis.Volatile organic compounds (VOCs) emitted from 36 clinical Ps. (belonging different multilocus sequence types) cultured liquid and on solid media were analysed gas chromatography mass spectrometry (GC-MS) selected ion flow tube (SIFT-MS). Several previously identified VOCs detected,...

RATIONALE Inflammatory bowel disease has a relatively large incidence in modern populations and the current diagnostic methods are either invasive or have limited sensitivity specificity. Thus, there is need for new non‐invasive its diagnosis therapeutic monitoring, breath analysis represents promising direction this area of research. Specifically, method needed absolute quantification pentane human breath. METHODS Selected ion flow tube mass spectrometry (SIFT‐MS) been used to study...

A study has been carried out of the volatile organic compounds present in exhaled breath 58 cystic fibrosis (CF) patients. An important observation is that acetic acid vapour concentration measured by selected ion flow tube mass spectrometry (SIFT-MS) significantly elevated CF patients, independent Pseudomonas aeruginosa (PA) infection status (PA-infected median 170 ppbv; PA-negative 182 ppbv), compared to healthy controls (median 48 ppbv). The cause for this may be decreased pH mucus lining...

A study has been carried out on the volatile organic compounds (VOCs) in exhaled breath of patients suffering from inflammatory bowel disease (IBD), comprising 136 with Crohn's (CD) and 51 ulcerative colitis (UC), together a cohort 14 healthy persons as controls. Breath samples were collected by requesting to inflate Nalophan bags, which then quantitatively analysed using selected ion flow tube mass spectrometry (SIFT-MS). Initially, focus was n-pentane that had previously quantified single...

The concentrations of ammonia, acetone, methanol, ethanol, propanol and hydrogen cyanide have been measured in the exhaled breath 26 young adults age 17/18 years, using selected ion flow tube mass spectrometry (SIFT-MS). Thus concentration distributions constructed are seen to be essentially log normal with median values parts per billion (ppb), being 317; 363; 238; 104; propanol, 13; (HCN), 8. There is a clear separation ethanol levels between those volunteers who had ingested sugary...

Abstract In selected ion flow tube mass spectrometry, SIFT‐MS, analyses of humid air and breath, it is essential to consider account for the influence water vapour in media, which can be profound analysis some compounds, including H 2 CO, S notably CO . To date, methane has not been considered, since known unreactive with 3 O + NO , most important precursor ions SIFT‐MS analyses, reacts only slowly other available ion, However, we have now experimentally investigated report that quantified...

A novel high-energy explosive material, FOX-7 (1,1-diamino-2,2-dinitroethylene), was studied using a combination of laser-induced breakdown spectroscopy (LIBS) and selected ion flow tube mass spectrometry (SIFT-MS). The LIBS technique uses short laser pulses (an ArF excimer laser) as the energy source to convert small quantities sample into plasma induce emission its molecular fragments or atoms. SIFT-MS is method for absolute quantification based on chemical ionization three reagent ions,...

The objective of this experimental study was to discover volatile metabolites present in exhaled breath that could be used as biomarkers gastro-esophageal reflux disease, GERD, one the most common causes chronic cough. An vitro model based on pork tissue samples exposed a challenge by artificial gastric fluid identify specific compounds chosen for quantification directly GERD patients and controls using selected ion flow tube mass spectrometry, SIFT-MS. GC/MS analyses headspace indicated...

The aim of the present study was to characterize volatile metabolites produced by genotypically diverse strains Stenotrophomonas genus in order evaluate their potential as biomarkers lung infection non-invasive breath analysis. Volatile organic compounds (VOCs) emitted from 15 clinical and five environmental belonging different genogroups maltophilia (n = 18) rhizophila 2) cultured Mueller-Hinton Broth (MHB) liquid media were analysed gas chromatography mass spectrometry (GC-MS) selected ion...

The industrial production of poly (ethylene terephthalate), PET, continues to increase and thus it is important understand the composition fumes resulting from its disposal as a part incinerated waste. In this study samples PET material were combusted in furnace corresponding German standard DIN 53,436 at temperatures 500°C, 800°C (in an air flow) also uncontrolled combustion air. gaseous products then analysed using three different analytical methods: high resolution Fourier transform...

The use of selected ion flow tube mass spectrometry (SIFT-MS) and gas chromatography-mass together with solid phase microextraction (GC-MS-SPME) has been compared in the analysis volatile compounds during dry fermented sausage processing. Thus, headspace (HS) samples sausages different fat contents was analyzed their manufacture using both techniques, significant positive correlations were found between SIFT-MS SPME-GC-MS measurements for pentanal, hexanal, 2-heptenal, octanal, 2-nonenal,...

Four types of explosives were studied using a combination Laser Induced Breakdown Spectroscopy (LIBS) and Selected Ion Flow Tube Mass Spectrometry (SIFT-MS). The LIBS technique uses short laser pulses (ArF excimer laser) as the energy source to convert small amounts samples into plasma produce emission from their molecular fragments or atoms. SIFT-MS is novel method for absolute quantification based on chemical ionization three precursor ions, with capability determine concentrations trace...

The meat industry is interested in rapid control of the sensory quality products. Selected ion flow tube mass spectrometry (SIFT-MS) has been applied to rapid, real-time quantification 31 volatile aroma compounds present headspace (HS) dry fermented sausages. Three batches sausages with different fat contents (10, 20, and 30%) were monitored throughout processing time. SIFT-MS revealed significant changes concentration all during Moreover, among various sausages, differences their HS...

As a contribution to the continuing search for breath biomarkers of lung and airways infection in patients with cystic fibrosis, CF, we have analysed volatile metabolites released vitro by Pseudomonas aeruginosa other bacteria involved respiratory infections these patients, i.e. those belonging Burkholderia cepacia complex, Staphylococcus aureus or Stenotrophomonas maltophilia. These opportunistic pathogens are generally harmless healthy people but they may cause serious severe underlying...

Selected ion flow tube mass spectrometry, SIFT-MS, has been widely used in industry and research since its introduction the mid-1990s. Previously described quantitation methods have advanced to include a gas standard for more robust repeatable analytical performance. The details of this approach calculate concentrations from ion–molecule reaction kinetics based on times instrument calibration functions determined known mix are discussed. Important practical issues such as overlap product...

Time-resolved Fourier transform (FT) spectrometry was used to study the dynamics of radical reactions forming HCN and HNC isomers in pulsed glow discharges through vapors BrCN, acetonitrile (CH(3)CN), formamide (HCONH(2)). Stable gaseous products discharge chemistry were analyzed by selected ion flow tube mass (SIFT-MS). Ratios concentrations HNC/HCN obtained using known transition dipole moments rovibrational cold bands v(1) found be range 2.2-3%. A kinetic model assess roles play formation...

Rationale The major objective of this exploratory study was to implement selected ion flow tube mass spectrometry, SIFT‐MS, as a method for the on‐line quantification volatile organic compounds, VOCs, in headspace ground roasted coffee. Methods optimal precursor ions and characteristic analyte were real‐time SIFT‐MS those VOCs that are most abundant or known contribute aroma. NO + reagent reactions exploited VOC analyses. identifications confirmed using gas chromatography/mass GC/MS, coupled...