A5046330630- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Airway Management and Intubation Techniques
- Head and Neck Cancer Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Infrared Thermography in Medicine
- Esophageal Cancer Research and Treatment
- Atomic and Subatomic Physics Research
- Lung Cancer Treatments and Mutations
- Pleural and Pulmonary Diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Cancer Diagnosis and Treatment
- Esophageal and GI Pathology
- Ultrasound in Clinical Applications
- Respiratory and Cough-Related Research
- Advanced Chemical Sensor Technologies
- Gastroesophageal reflux and treatments
- Spectroscopy and Chemometric Analyses
- Pneumothorax, Barotrauma, Emphysema
- Delphi Technique in Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Charles University
2014-2024
General University Hospital in Prague
2014-2024
LRS Institute of Tuberculosis and Respiratory Diseases
2021
Antrim Area Hospital
2020
Ocní klinika
2018
Na Homolce Hospital
2007-2011
The objective of this experimental study was to discover volatile metabolites present in exhaled breath that could be used as biomarkers gastro-esophageal reflux disease, GERD, one the most common causes chronic cough. An vitro model based on pork tissue samples exposed a challenge by artificial gastric fluid identify specific compounds chosen for quantification directly GERD patients and controls using selected ion flow tube mass spectrometry, SIFT-MS. GC/MS analyses headspace indicated...
Background The diagnosis of advanced lung cancer is made with minimally invasive procedures. This often results in the availability cytological material only for subtype determination and companion diagnostic testing, latter being technically clinically validated on histological only. Thus, primary objective MO29978 clinical study was to assess programmed death ligand 1 (PD‐L1) protein expression cytology samples as surrogates histology patients cancer. Methods Formalin‐fixed,...
Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) has an important role in the diagnosis and staging of lung cancer. Evaluation programmed death ligand 1 (PD-L1) expression molecular profiling become standard care but cytological samples frequently contain insufficient tumor cells. The 22G Acquire with Franseen tip was developed to perform biopsy (TBNB) improved tissue specimens. This study evaluated if TBNB results enhanced PD-L1 suitability rate compared regular...
Abstract Background Management of non-small-cell lung cancer (NSCLC) is affected by regional specificities. The present study aimed at determining diagnostic and therapeutic procedures including outcome patients with NSCLC stage III in the real-world setting Central European countries to define areas for improvements . Patients methods This multicentre, prospective non-interventional collected data a web-based registry analysed them centrally. Results Between March 2014 2017, (n=583)...
Introduction Despite many technological advances, the diagnostic yield of bronchoscopic peripheral lung nodule analysis remains limited due to frequent mispositioning. Needle-based confocal laser endomicroscopy (nCLE) enables real-time microscopic feedback on needle positioning, potentially improving sampling location and yield. Previous studies have defined validated nCLE criteria for malignancy, airway parenchyma. Larger demonstrating effect are lacking. We aim investigate if nCLE-imaging...
Videolaryngoscopes may reduce cervical spine movement during tracheal intubation in patients with neck trauma. This manikin study aimed to compare the performance of disposable non-channeled and channeled blades King Vision™ videolaryngoscope simulated injury. Fifty-eight anesthesiologists training intubated TruMan immobilized using each blade a randomized order. The primary outcome was time needed for intubation, secondary aims included total success rate, required visualization larynx,...
<b>Introduction:</b> Bronchial thermoplasty (BT) is a procedure-based treatment for patients ≥18 years with severe persistent asthma not well controlled medication. The BT Global Registry (BTGR) collects data on subjects undergoing this procedure. <b>Objectives:</b> To describe the results of study after 1 year follow-up. <b>Methods:</b> BTGR an all-comer, prospective, open-label, multi-center enrolling adult indicated and treated BT. Baseline characteristics collected included demographics,...
Prolonged artificial pulmonary ventilation by tracheostomy tube (>30 days) doubled the risk of stenosis (relative risk, RR = 2.04, p 0.002). Critically ill patients with repeated tracheotomies were more than six times likely to experience (RR 6.44, p< 0.001) other critically patients.In this retrospective study, we describe occurrence laryngotracheal (LTS) in after elective who had undergone treatment for LTS at Na Homolce Hospital Prague, Czech Republic.We studied 28 diagnosed symptomatic...
Emphysema is a leading cause of disability and death. Patients who require ventilator support as result respiratory failure have limited treatment options. We report successful outcome for dependent patient in whom endobronchial valves were inserted into lobes assessed being without collateral ventilation. A 54 year old male had been two months due to insufficiency from emphysema. Prior admission, FEV1 was 0.89L (25% predicted) RV 4.5L (205% predicted). CT scan showed destruction right lower...
Pulmonary infiltration is an infrequent organ involvement in Waldenström's disease (WD). Diffuse infiltration, isolated parenchymatous nodules, and pleural effusion are the most common manifestations of WD, while endobronchial mass extremely rare. We present a case report 66-year-old man with long-standing history who developed febrile neutropenia after therapy rituximab, cyclophosphamide, dexamethasone. X-ray CT scan showed consolidation consistent right-sided pneumonia. Surprisingly,...
The significance of extraesophageal reflux as a risk factor in lung adenocarcinoma has been understudied. In this study, we investigated whether leads to higher pepsin concentrations bronchoalveolar lavage (BAL) patients with compared controls. Subjects were recruited from non-smoker (lifelong non-smokers and ex-smokers more than 5 years non-smoking history) who had undergone bronchoscopy due pulmonary abnormalities on CT scan met the inclusion criteria. Based histological verification...
Fine-needle aspiration biopsy is crucial for modern diagnostics of endoscopic procedures and thus an efficient reliable method increasing yields urgently needed. In our study, we address the limited availability high price rapid onsite evaluation (ROSE) technique by introducing near-infrared on-site (NOSE) consisting spectral measurement radiation (NIR) transmitted through evaluated material. For this purpose, designed a special optical probe two fibres, which one source fibre second...
Akutně vzniklá mitrální insuficience je život ohrožující stav, jehož příčinou může být i velká fyzická zátěž, zejména při současné myxomatózní degeneraci chlopně.Mortalita neléčené vady 75 % během prvních 24 hodin po vzniku, rovněž perioperační mortalita vysoká.Kasuistika uvádí případ 57letého muže, aktivního sportovce (vytrvalostního běžce), zdravotní stav byl řádně vyšetřován na pracovišti sportovní medicíny v SRN, vždy s normálními nálezy. Bezprostředně absolvování maratonského běhu si...
Abstract Background: Lung cancer screening in high-risk population increases the proportion of patients diagnosed at a resectable stage. Aims: To optimize selection criteria and quality indicators for lung by low-dose CT (LDCT) Czech individuals. compare influence on stage time diagnosis with distribution an unscreened population. estimate impact life-years lost according to stage-specific survival screened calculate cost-effectiveness program. Methods: Based evidence from large national...