A5084383026- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Tracheal and airway disorders
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Esophageal Cancer Research and Treatment
- Reproductive biology and impacts on aquatic species
- Salivary Gland Tumors Diagnosis and Treatment
- Protein Interaction Studies and Fluorescence Analysis
- Neuroblastoma Research and Treatments
- Gastric Cancer Management and Outcomes
- Actinomycetales infections and treatment
- Spine and Intervertebral Disc Pathology
- Advanced Biosensing Techniques and Applications
- Ecology and Conservation Studies
- Voice and Speech Disorders
- Occupational exposure and asthma
- Cancer therapeutics and mechanisms
- Infectious Diseases and Mycology
- Regulation of Appetite and Obesity
- Synthesis and Catalytic Reactions
- Lung Cancer Research Studies
- Curcumin's Biomedical Applications
- Corneal Surgery and Treatments
Institute of Animal Biochemistry and Genetics of the Slovak Academy of Sciences
2014-2024
Slovak Medical University
2024
University Hospital Bratislava
2024
Comenius University Bratislava
2024
Slovak Academy of Sciences
2014-2024
Vysoká Škola Zdravotníctva a Sociálnej Práce sv. Alžbety
2020-2021
Onkologický Ústav Svätej Alžbety
2012
University of Pavol Jozef Šafárik
2009-2010
Univerzitná Nemocnica Louisa Pasteura
2001-2006
Self-assembled nanostructures of amphiphilic gradient copoly(2-oxazoline)s have recently attracted attention as promising delivery systems for the effective hydrophobic anticancer drugs. In this study, we investigated effects increasing side chain length on self-assembly copolymers composed 2-ethyl-2-oxazoline hydrophilic comonomer and various 2-(4-alkyloxyphenyl)-2-oxazolines comonomers. We show that size formed polymeric nanoparticles depends structure copolymers. Moreover, stability...
There has been increasing interest in fluorescence-based imaging techniques clinical practice, with the aim to detect and visualize tumour configuration border healthy tissue.Strong photodynamic activity of hypericin (Hyp) can be improved by various molecular transport systems (e.g.LDL).Our was examine pharmacokinetics Hyp presence LDL particles on ex ovo chorioallantoic membrane (CAM) Japanese quail implanted TE1 spheroids (human squamocellular carcinoma).Spheroids were CAM surface...
Photosensitizing properties of hypericin are well known, and the chicken chorioallantoic membrane has previously been used to test photodynamic effects other substances. In our study effect in ex ovo quail model was evaluated. Steady-state time-resolved fluorescence spectroscopy solution PEG-400 its mixture PBS performed assess characterize process aggregation disaggregation during drug formulation preparation. A therapeutical (2 µg/g embryo weight) topically applied on CAM into silicone...
Due to the simple one-step preparation method and a promising application in biomedical research, amphiphilic gradient copoly(2-oxazoline)s are gaining more interest compared their analogous block copolymers. In this work, curcumin solubilization ability was tested for series of with different lengths hydrophobic side-chains, consisting 2-ethyl-2-oxazoline as hydrophilic monomer 2-(4-alkyloxyphenyl)-2-oxazoline monomer. It is shown that length side-chain copolymers plays crucial role loading...
Autofluorescence bronchoscopy (AFB) has been shown to be sensitive detect preneoplastic lesions in central lung airways system. In early stages of carcinogenesis, up-regulation cyclooxygenase (COX)-2, Ki67 and/or increased angiogenesis may play a role by promoting the proliferation tumoral cells and their resistance apoptosis, as well angiogenesis, tumor cell invasion setting up metastatic process. The present study compared expression proliferative (COX-2, PCNA) angiogenic markers (CD34...
Pathological angiogenesis characterized by uncontrollable vessel growth is an accompanying feature of many diseases. The avian embryo chorioallantoic membrane (CAM) excellent model for research. In our study we used a less common Japanese quail CAM the testing angiogenic potential leptin, high-molecular (heparin sodium) andlow-molecular (nadroparin calcium) heparins. Heparins play significant role in vascular endothelial cell function, and they are able to modulate activities factors. On...
Fine-needle aspiration biopsy is crucial for modern diagnostics of endoscopic procedures and thus an efficient reliable method increasing yields urgently needed. In our study, we address the limited availability high price rapid onsite evaluation (ROSE) technique by introducing near-infrared on-site (NOSE) consisting spectral measurement radiation (NIR) transmitted through evaluated material. For this purpose, designed a special optical probe two fibres, which one source fibre second...
Obstructive sleep apnea syndrome (OSAS) is a frequently underdiagnosed disorder marked by recurrent episodes of and/or hypopnea during sleep, primarily resulting from the partial or complete collapse upper airway. OSAS significantly affects patients’ health and quality life. Additionally, it recognized risk factor for inducing microsleep daily activities, particularly in occupations such as professional driving, where sustained attention critical. The aim our study was to identify an...