A5064519824- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Porphyrin and Phthalocyanine Chemistry
- Nanoparticle-Based Drug Delivery
- Analytical Chemistry and Sensors
- Cancer, Hypoxia, and Metabolism
- Mesoporous Materials and Catalysis
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Protein Interaction Studies and Fluorescence Analysis
- Lipid Membrane Structure and Behavior
- Molecular Sensors and Ion Detection
- Lanthanide and Transition Metal Complexes
- Laser Applications in Dentistry and Medicine
- Photoreceptor and optogenetics research
- Curcumin's Biomedical Applications
- Metal complexes synthesis and properties
- Alzheimer's disease research and treatments
- Mass Spectrometry Techniques and Applications
- Cancer therapeutics and mechanisms
- Advanced Fluorescence Microscopy Techniques
- Characterization and Applications of Magnetic Nanoparticles
- Luminescence and Fluorescent Materials
- Photosynthetic Processes and Mechanisms
- Reproductive biology and impacts on aquatic species
University of Pavol Jozef Šafárik
2016-2025
Bioscience (Slovakia)
2016-2025
Institute of Animal Biochemistry and Genetics of the Slovak Academy of Sciences
2023-2025
Slovak Academy of Sciences
2023-2025
École Polytechnique Fédérale de Lausanne
2014-2023
Institute of Physics of the Slovak Academy of Sciences
2023
Science & Technology Park (Czechia)
2020
Technical University of Košice
2020
Sorbonne Université
2010-2012
Centre National de la Recherche Scientifique
2010-2012
A new gradient copolymer has been synthesized by the living cationic ring-opening polymerization of hydrophilic 2-ethyl-2-oxazoline with lipophilic 2-(4-dodecyloxyphenyl)-2-oxazoline (EtOx-grad-DPOx). The prepared is capable assembling in water to yield polymeric nanoparticles that are successfully loaded an anticancer agent, curcumin. Self-assembly was found be tuned polarity as well hydrogen bonding ability solvents. Solvent took distinctive role preparation unloaded and curcumin-loaded...
There seems to be general agreement that oxidative stress is involved in many pathological conditions including Parkinson's, Alzheimer's, and other neurodegenerative diseases, overall aging. Cerium oxide nanoparticles, also known as nanoceria (CeO2-NPs), have shown promise catalytic antioxidants, based on their ability switch between Ce3+ Ce4+ valence states. In the present work we synthesized characterized CeO2-NPs, examined effect of CeO2-NPs amyloidogenesis insulin, analyzed impact...
Abstract The dependence of the uptake hypericin (Hyp) by human glioma U‐87 MG cells on level expression low‐density lipoprotein (LDL) receptors has been studied in this work. A special role LDL receptor‐pathway for Hyp delivery to presence was revealed substantial increase situation, when number cell surface elevated. Moreover, colocalization experiments showed lysosomal localization following and that concentration these organelles enhanced with elevated incubation medium contained LDL....
Glioblastoma is one of the most aggressive types tumors. Although few treatment options are currently available, new modalities needed to improve prognosis. In this context, photodynamic therapy (PDT) a promising adjuvant modality. present work, hypericin-mediated PDT (hypericin-PDT, 2 J/cm2) U87 MG cells combined with (2 min, 15 mW/cm2 at 808 nm) photobiomodulation (PBM). We observed that PBM stimulates autophagy, which, in combination PDT, increases efficacy and leads apoptosis. Confocal...
Early diagnosis and treatment of cancer is rapidly advancing thanks to the development nanotechnology. Here, upconversion nanoparticles (UCNPs) are particularly promising as they finding a wide range of...
Measuring tissue oxygenation in vivo is of interest fundamental biological as well medical applications. One minimally invasive approach to assess the oxygen partial pressure (pO2) measure oxygen-dependent luminescence lifetime molecular probes. The relation between pO2 and probes’ governed by Stern-Volmer equation. Unfortunately, virtually all oxygen-sensitive probes based on this principle induce some degree phototoxicity. For that reason, we studied sensitivity phototoxicity...
Self-assembled nanostructures of amphiphilic gradient copoly(2-oxazoline)s have recently attracted attention as promising delivery systems for the effective hydrophobic anticancer drugs. In this study, we investigated effects increasing side chain length on self-assembly copolymers composed 2-ethyl-2-oxazoline hydrophilic comonomer and various 2-(4-alkyloxyphenyl)-2-oxazolines comonomers. We show that size formed polymeric nanoparticles depends structure copolymers. Moreover, stability...