A5101840816- Clostridium difficile and Clostridium perfringens research
- Congenital Heart Disease Studies
- Pulmonary Hypertension Research and Treatments
- Yersinia bacterium, plague, ectoparasites research
- Cardiovascular Function and Risk Factors
- Medical Imaging Techniques and Applications
- Parasitic infections in humans and animals
- Radiomics and Machine Learning in Medical Imaging
- Radiation Dose and Imaging
- Bacterial Infections and Vaccines
- Ultrasound in Clinical Applications
- Antimicrobial Resistance in Staphylococcus
- Coronary Artery Anomalies
- Glycosylation and Glycoproteins Research
- Vascular Procedures and Complications
- Advanced X-ray and CT Imaging
- Aortic Disease and Treatment Approaches
- COVID-19 Clinical Research Studies
- Pancreatitis Pathology and Treatment
- Dental Health and Care Utilization
- Cancer Cells and Metastasis
- Abdominal Trauma and Injuries
- Cancer, Hypoxia, and Metabolism
- Dialysis and Renal Disease Management
- Bacterial Identification and Susceptibility Testing
Jožef Stefan Institute
2024
General University Hospital in Prague
2020-2023
Charles University
2020-2023
National Institute of Biology
2022
Comenius University Bratislava
2018-2021
Meningococcal glycoconjugate vaccines sourced from capsular polysaccharides (CPSs) of pathogenic Neisseria meningitidis strains are well-established measures to prevent meningococcal disease. However, the exact structural factors responsible for antibody recognition not known. CPSs serogroups Y and W differ by a single stereochemical center, yet they evoke specific immune responses. Herein, we developed monoclonal antibodies (mAbs) targeting C, Y, evaluated their ability kill bacteria. We...
Summary Human alveolar echinococcosis (AE) is a silently-progressing disorder that has become threat in many countries. Since 2000, when the first case was recorded, number of human AE patients Slovakia on continuous raise. The article presents rare with infiltration adrenal gland and discusses problems associated differential diagnosis disease. In 2016, abdominal ultrasound performed due pain complaint showed presence cystic lesions right liver lobe 54-year old female patient. During...
Objective The aim of this study was to compare three different reconstruction algorithms for the volumetry visceral adipose tissue (VAT) and subcutaneous (SAT) on ultra‐low‐dose computed tomography (CT) images. Methods Thirty‐seven male patients underwent CT at level fourth lumbar vertebra (22.5 mm in z‐axis). acquisitions were reconstructed 5‐mm slices with 50% overlap using filtered back projection (FBP), hybrid iterative (HIR), model‐based (IMR) techniques. volume VAT SAT measured an...
Objective. To determine the association between COVID-19 infection and peripancreatic changes on CT as a sign of acute pancreatic injury. Methods. Retrospective analysis examinations in patients with confirmed yielded 103 instances. An age- gender-matched cohort without was found. were evaluated for stranding or edema, fluid collection, necrosis, any other explanation. Depicted pulmonary parenchyma possible COVID-19-related changes. Clinical laboratory data retrieved from clinical database....
In this prospective randomized single-blinded study (reg. ISRCTN11414306), 76 patients with a dysfunctional dialysis fistula or graft due to single de novo recurrent stenosis in the access circuit were receive either conventional PTA (POBA) as standard of care (n = 38) + adjunctive drug-coated (paclitaxel-resveratrol matrix) SeQuent® Please OTW balloon 38, DCB). Patients scheduled for follow-up at 3, 6, 9, and 12 months. The time clinically driven target-lesion reintervention rate (primary...
Abstract Introduction: Decrease of nonspecific imunity in patients and the treatment with broad spectrum antibiotics form appropriate conditions for appearance medically severe Clostridium difficile infection (CDI) - enterocolitis that can have characteristics community or hospital acquired (HAI). The aim our work is to identify trend their incidence Slovakia define risk groups according age department hospitalisation. Material Methods: Retrospective analysis comparison CDI was performed...
Abstract Background: Lung cancer screening in high-risk population increases the proportion of patients diagnosed at a resectable stage. Aims: To optimize selection criteria and quality indicators for lung by low-dose CT (LDCT) Czech individuals. compare influence on stage time diagnosis with distribution an unscreened population. estimate impact life-years lost according to stage-specific survival screened calculate cost-effectiveness program. Methods: Based evidence from large national...
Clostridium (Clostridioides) difficile is the most common pathogen of nosocomial and antibiotic-related diarrhea in health-care facilities. The aim analysis was to show testing algorithm identify hypervirulent strains (suspected RT 027).The retrospective patient samples suspected on CDI carried out by a two-step algorithm. Biological specimens were analysed GDH or culture, immunoenzymatic assay toxins A/B selected also real-time PCR.In 1006 specimen CDI, 202 evaluated as positive Conflicting...
Abstract The oral cavity is a biologically significant and complex site of the human body. It gateway into internal environment organism. There are many processes, such as beginning digestion, speech creation, sensory perception taste. Oral health closely related to general person. contains an enormous number microorganisms that can cause various diseases. bacteria responsible for diseases in mouth, but also seriously harm health. microbiome serves indicator health, respectively morbidity...
Abstract Background Intratumoral heterogeneity plays an important role in glioblastoma (GB) resistance to standard therapy consisting of irradiation and chemotherapy with temozolomide (TMZ). However, classical vitro GB models fail represent the complex cellular composition tumors vivo, which hinders relevant examination therapeutic response. To overcome these limitations, we studied effects TMZ a novel patient-derived organoid model. Material Methods We established model by protocol recently...