A5033068258- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Plant Virus Research Studies
- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- Herpesvirus Infections and Treatments
- Virus-based gene therapy research
- CRISPR and Genetic Engineering
- Identification and Quantification in Food
- Animal Virus Infections Studies
- RNA and protein synthesis mechanisms
- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Bacteriophages and microbial interactions
- Plant tissue culture and regeneration
- RNA Research and Splicing
- Lymphoma Diagnosis and Treatment
- Hepatitis B Virus Studies
- T-cell and Retrovirus Studies
- Parvovirus B19 Infection Studies
- Primate Behavior and Ecology
- Hepatitis C virus research
- Zoonotic diseases and public health
University of Amsterdam
2013-2024
Amsterdam University Medical Centers
2020-2024
Amsterdam Institute for Addiction Research
2022
Amsterdam UMC Location University of Amsterdam
2002-2018
Institute of Infection and Immunity
2011-2012
GTx (United States)
2010
Leiden University
1990-1991
Vrije Universiteit Amsterdam
1985-1987
We are interested in the influence of nucleotide composition on fundamental characteristics virus RNA genome. Most viruses have genomes with a distinct composition, e.g. ranging from minimally 12.9 % to maximally 40.3 (C- and U-count, respectively, coronavirus HKU). present global analysis diverse types, including plus-strand, minus-strand double-strand viruses, for impact this preference predicted structure genome that is packaged virion particles codon usage viral open reading frames....
Sialoadhesin (CD169, siglec-1 or Sn) is an activation marker seen on macrophages in chronic inflammatory diseases and tumours, subsets of tissue macrophages. CD169 highly expressed by present AIDS-related Kaposi's sarcoma lesions. It also increased blood monocytes HIV-1 infected patients with a high viral load despite antiretroviral treatment.We investigated expression sialoadhesin untreated HHV-8 patients, real-time PCR FACS analysis to establish its relation infection disease progression....
Journal Article Analysis of upstream activation sites yeast ribosomal protein genes Get access Lambertus P. Woudt, Woudt Biochemisch Laboratorium, Vrije Universiteitde Boelelaan 1083, 1081 HV Amsterdam, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar Willem H. Mager, Mager René T. M.Nieuwint, M.Nieuwint Gertrude M. Wassenaar, Wassenaar Antoinette C. van der Kuyl, Kuyl Jan J. Murre, Murre Marco F.M. Hoekman, Hoekman Paul G.M. Brockhoff,...
In vitro, animal, and mathematical models suggest that human immunodeficiency virus (HIV) co- or superinfection would result in increased fitness of the pathogen and, possibly, virulence. However, patients, impact dual HIV type 1 (HIV-1) infection on disease progression is unclear, because parameters relevant for have not been strictly analyzed. The objective present study to analyze effect HIV-1 infections a well-defined cohort men who sex with men. Between 2000 2009, 37 had primary subtype...
Different classes of porcine endogenous retroviruses (PERVs), which have the potential to infect humans during xenotransplantation, been isolated from pig genome. Because vertebrate genomes may contain numerous retrovirus sequences, genome was examined for additional retroviruses, resulting in isolation a novel, complete genome, designated PERV-E. The gag , pol and env genes PERV-E are closely related those human (HERV) 4-1, belongs HERV-E family. Results studies determine presence copy...
A complete endogenous type D viral genome has been isolated from a baboon genomic library. The provirus, simian retrovirus (SERV), is 8,393 nucleotides long and contains two terminal repeats genes for gag, pro, pol, env. primer binding site complementary to tRNA(Lys)3, like in lentiviruses. env GP70 protein highly homologous that of virus (BaEV). PCR analysis primate DNA showed related proviral sequences are present Old World monkeys the subfamily Cercopithecinae but not apes humans....
ABSTRACT Analysis of a cat genomic DNA library showed that cats harbor previously unrecognized endogenous type C retrovirus, whose env gene has homology to the murine Fv-4 resistance gene. This unique designated FcEV ( Felis catus retrovirus), pol gene, closely related primate Papio cynocephalus virus (PcEV) , not overlapping unlike in other retroviruses, and is presumably present higher copy number than RD-114. Phylogenetic analysis RD-114 fragments amplified from species comparison with...
Xenotropic murine leukaemia virus-related virus (XMRV) is a recently discovered human gammaretrovirus with yet unknown prevalence and transmission route(s). Its presence in prostate stromal fibroblasts prostatic secretions suggests that XMRV might be sexually transmitted. We chose to study compartment closely connected the prostate, location where was detected independent studies. Seminal plasma samples from HIV-1 infected men were examined as they have an increased probability of acquiring...
The BEEHIVE (Bridging the Evolution and Epidemiology of HIV in Europe) project aims to analyse nearly-complete viral genomes from >3000 HIV-1 infected Europeans using high-throughput deep sequencing techniques investigate virus genetic contribution virulence. Following development a computational pipeline, including new de novo assembler for RNA genomes, generate larger contiguous sequences (contigs) abundance short sequence reads that characterise data, another area determines genome...
PCR amplification of baboon endogenous virus (BaEV) long terminal repeat, reverse transcriptase gene, and env fragments from 24 different species African monkeys indicates that BaEV is less widespread than was formerly thought. Instead being present in every primates, can be found only baboons, geladas, mangabeys (all belonging to the Papionini tribe) green monkey (Cercopithecus aethiops)subspecies. BaEV, which activated gelada tissues, most likely introduced germ line recently (less a few...