A5045655742- Probiotics and Fermented Foods
- Polysaccharides and Plant Cell Walls
- Microbial Metabolites in Food Biotechnology
- Gut microbiota and health
- Graphene and Nanomaterials Applications
- Advanced Drug Delivery Systems
- Immune cells in cancer
- Fungal Biology and Applications
- Cancer Research and Treatments
- Clostridium difficile and Clostridium perfringens research
- Digestive system and related health
- Nanoplatforms for cancer theranostics
- Phagocytosis and Immune Regulation
- Wound Healing and Treatments
- Immune responses and vaccinations
- Proteins in Food Systems
- Seaweed-derived Bioactive Compounds
- Food composition and properties
- Neuroinflammation and Neurodegeneration Mechanisms
Chinese University of Hong Kong
2020-2024
Beijing University of Chinese Medicine
2023
South China Agricultural University
2021
Xi'an University of Technology
2009
Abstract Treatment for inflammatory bowel disease (IBD) is challenging since current anti-inflammatory and immunosuppressive therapies do not address the underlying causes of illness, which include increased levels reactive oxygen species (ROS) dysbiosis gut commensal microbiota. Additionally, these treatments often have systemic off-target effects adverse side effects. In this study, we developed a prebiotic yeast β-glucan nanocomplex coated with bio-adhesive polydopamine (YBNs@PDA) to...
In this study, 22 strains of exopolysaccharides-producing lactic acid bacteria were isolated from silage, and the strain SSC-12 with highest exopolysaccharide (EPS) production was used as test strain. The identified Pediococcus pentosaceus, based upon 16S rDNA gene sequencing Neighbor Joining (NJ) phylogenetic analysis. analysis kinetic results EPS generation showed that reached maximum value at 20 h culture. characterization study produced by a homogeneous heteropolysaccharide comprising...
β-d-glucans have the potential of serving as both macrophage-targeted carriers and immune stimulators via inducing trained immunity in macrophages. In this study, a carboxymethylated β-glucan from mushroom sclerotium Pleurotus tuber-regium (CMPTR) was combined with iron oxide nanoparticles (IONPs) to form nanocomplexes (CMPTR/IONPs) particle size around 193 ± 7 nm, which could exert concerted effect on proinflammatory M1 phenotype macrophages for immunotherapy. This nanocomplex exhibited...
Gut microbiota has been described as a new 'organ' that interferes with host physiology by its metabolites produced from the utilization and biotransformation of undigested food components. Fu Ling (FL), sclerotia fungi Wolfiporia cocos, contains β-glucan, which is known natural polysaccharide strong medicinal efficacy. This study endeavors to evaluate fermentability FL polysaccharides extracted sclerotia. An in vitro fermentation structurally characterized β-glucan human fecal was...
Abstract Background: The exopolysaccharides (EPS) produced by lactic acid bacteria (LAB) are widely used in various fields because of their safety and biological activities. In this study, we extracted characterized the composition as well antioxidant antibacterial activities EPS from Pediococcus pentosaceus SSC-12 isolated silage. Results: LAB strain was screened identified , based upon 16S rDNA gene sequencing Neighbor Joining (NJ) phylogenetic analysis. analysis production kinetics...
We proposed a framework with parametric modeling to obtain biological relevant parameters from the total probiotic growth pattern and metabolite production curves. The lag phase, maximum increase rate, capacity were obtained via 205-h exploratory in vitro fermentation of library 13 structural-characterized prebiotic candidates against an exclusively breastfed infant fecal inoculum. also conducted 16S rRNA amplicon sequencing Moreover, we introduce robust composite metabolite-based indicator...