A5071291110- Zebrafish Biomedical Research Applications
- Phytochemical compounds biological activities
- Agricultural and Food Sciences
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Nematode management and characterization studies
- Natural product bioactivities and synthesis
- Protein Hydrolysis and Bioactive Peptides
- Medicinal Plants and Neuroprotection
- Fungal Biology and Applications
- Environmental Sustainability and Education
- Water Quality and Pollution Assessment
- Cholinesterase and Neurodegenerative Diseases
- Mycorrhizal Fungi and Plant Interactions
- Malaria Research and Control
- Phenothiazines and Benzothiazines Synthesis and Activities
- Growth and nutrition in plants
- Chemistry Education and Research
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- DNA Repair Mechanisms
- Estrogen and related hormone effects
- Piperaceae Chemical and Biological Studies
- Chemical synthesis and alkaloids
Deoxi Biotecnologia (Brazil)
2025
Universidade Estadual do Ceará
2020-2024
Universidade Federal do Ceará
2004-2010
Antimycobacterial and cytotoxicity activity of synthetic natural compounds. Secondary metabolites from Curvularia eragrostidis Drechslera dematioidea, Clusia sp. floral resin, alkaloids Pilocarpus alatus, salicylideneanilines, piperidine amides, the amine 1-cinnamylpiperazine chiral pyridinium salts were assayed on Mycobacterium tuberculosis H37Rv. N-(salicylidene)-2-hydroxyaniline was most effective compound with a minimal inhibitory concentration (MIC) 8 µmol/L. Dihydrocurvularin...
It has been reported that pisosterol was active against cancer cells but lacked activity on the development of sea urchin eggs. Recently, it induces differentiation in leukemia cell line. The present study evaluated vivo antitumor a triterpene isolated from Pisolithus tinctorius. Histopathological and morphological analyses tumor organs, including liver, spleen kidney, were performed order to evaluate toxicological aspects associated with treatments. Antitumor (50 or 100 mg/m2) confirmed...
Abstract Pisolithus tinctorius (Basidiomycete) is an ectomicorrhizal fungus found in the roots and soil surrounding of many species eucalyptus pine trees. The present work verified cytotoxic potential pisosterol, a triterpene isolated from P. collected Northeast region Brazil, on three different animal cell models: mouse erythrocytes, sea urchin embryos tumor cells. Pisosterol lacked activity erythrocytes as well development eggs, but strongly inhibited growth all seven lines tested,...
Abstract Despite the remarkable progress in characterization of molecular pathogenesis glioblastoma multiforme (GBM), these tumors remain incurable and, most cases, refractory to aggressive cytotoxic treatments. We conducted a morphological and cytogenetic study two GBM cell lines (U343 AHOL1), before after treatment with pisosterol (at 0.5, 1.0 1.8 µg ml −1 ), triterpene isolated from fungus Pisolithus tinctorius . No significant alteration was observed morphology frequency chromosomal...
A água, por ser um recurso natural precioso e necessário para a existência do homem, torna-se objeto de estudo frequente nos laboratórios todo o mundo. No nordeste brasileiro, especificamente na zona rural, água consumida pelas comunidades geralmente é proveniente chuva armazenada em cisternas. Para consumo humano, se faz necessária uma avaliação da qualidade desta água. Os padrões potabilidade são regulados pela Portaria 2.914/2011 Ministério Saúde. O com indicadores fora dos parâmetros...
The composition and nematicidal activity of the essential oils from leaves native six cultivated varieties P. microphyllus are reported. Twenty-nine compounds were identified (86.2% sesquiterpenes 13.8% aliphatic ketones) which (E)-caryophyllene, germacrene-D, caryophyllene oxide, 2-tridecanone, 1-hydroxy-2-tridecanone found in all analyzed oils. was evaluated against second-stage juvenile nematode Meloidogyne incognita. Essential Xingu Linha V showed high activity, while no for other This...