A5068846150- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Autoimmune and Inflammatory Disorders Research
- Platelet Disorders and Treatments
- Acute Myeloid Leukemia Research
- Urinary Tract Infections Management
- Pediatric Urology and Nephrology Studies
- Nitric Oxide and Endothelin Effects
- Urological Disorders and Treatments
- RNA Interference and Gene Delivery
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Uterine Myomas and Treatments
- Animal Nutrition and Physiology
- Glioma Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Complement system in diseases
- Lymphoma Diagnosis and Treatment
- Cystic Fibrosis Research Advances
- Parvovirus B19 Infection Studies
- Sarcoidosis and Beryllium Toxicity Research
- Autoimmune Bullous Skin Diseases
Rijnstate Hospital
2025
University Medical Center Utrecht
2011-2024
Peter MacCallum Cancer Centre
2019-2020
Ziekenhuis Gelderse Vallei
2015-2017
Independent Dance
2015
Center for Translational Molecular Medicine
2015
Wilhelmina Children's Hospital
2011-2014
Utrecht University
2014
University of Michigan
2010
Maastricht University
2009-2010
REVIEW article Front. Immunol., 07 March 2012Sec. Antigen Presenting Cell Biology Volume 3 - 2012 | https://doi.org/10.3389/fimmu.2012.00037
The poor survival rates of refractory/relapsed acute myeloid leukemia (AML) patients after haematopoietic cell transplantation (HCT) requires the development additional immune therapeutic strategies. As elicitation tumor-antigen specific cytotoxic T lymphocytes (CTLs) is associated with reduced relapses and enhanced survival, priming these CTLs using an anti-AML vaccine may result in long-term immunity against AML. Cord blood (CB), as allogeneic HCT source, provide a unique setting for such...
Reactivation of human cytomegalovirus (CMV) is hazardous to patients undergoing allogeneic cord blood transplantation (CBT), lowering survival rates by approximately 25%. While antiviral treatment ameliorates viremia, complete viral control requires CD8+ T-cell-driven immunity. Mouse studies suggest that cognate antigen-specific CD4+ T-cell licensing dendritic cells (DCs) required generate effective responses. For humans, this was not fully understood. We here show T are essential for DCs...
Sex hormones have an important influence on cardiovascular physiology and pathophysiology sex differences in vascular reactivity been widely demonstrated. In the present study we hypothesized 1) presence of sexual dimorphism chicken ductus arteriosus (DA) responsiveness to contractile relaxant stimuli 2) that estrogens are vasoactive DA. vitro contractions (assessed with a wire myograph) induced by normoxia, KCl, 4-aminopyridine, norepinephrine, phenylephrine, U46619, or endothelin-1, as...
EDITORIAL article Front. Immunol., 17 June 2014Sec. Antigen Presenting Cell Biology Volume 5 - 2014 | https://doi.org/10.3389/fimmu.2014.00287
Elicit potent CD8+ T cell responses by dentritic (DC) vaccination to reduce viral reactivations in children and adults after cord blood transplantation (CBT). Although CB grafts have multiple advantages over conventional stem grafts, relapses re-activations remain serious obstacles undergoing CBT. New strategies are needed increase early specific adaptive immune CBT order establish full clearance of, long-term immunological memory against viruses. Improvement the presentation of...