A5066553704- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Immune Response and Inflammation
- Influenza Virus Research Studies
- Antifungal resistance and susceptibility
- Gastric Cancer Management and Outcomes
- Reproductive Health and Technologies
- Reproductive Health and Contraception
- Colorectal Cancer Surgical Treatments
- Esophageal Cancer Research and Treatment
- Facial Trauma and Fracture Management
- Legionella and Acanthamoeba research
- Pneumothorax, Barotrauma, Emphysema
- Homicide, Infanticide, and Child Abuse
- Global Cancer Incidence and Screening
- Colorectal Cancer Screening and Detection
- Neuroscience and Music Perception
- Functional Brain Connectivity Studies
- Infective Endocarditis Diagnosis and Management
- Neural dynamics and brain function
- Global Health Workforce Issues
- Diphtheria, Corynebacterium, and Tetanus
- Body Contouring and Surgery
- IgG4-Related and Inflammatory Diseases
- Inhalation and Respiratory Drug Delivery
Brown University
2024
Columbia University
2022
NHS Grampian
2021
National University of Ireland, Maynooth
1997-1999
University College Dublin
1997
Using a murine respiratory challenge model we have previously demonstrated role for Th1 cells in natural immunity against Bordetella pertussis, but could not rule out antibody. Here that B. pertussis infection of mice with targeted disruptions the genes IFN-γ receptor resulted an atypical disseminated disease which was lethal proportion animals, and characterized by pyogranulomatous inflammation postnecrotic scarring livers, mesenteric lymph nodes kidneys. Viable virulent bacteria were...
Using a murine respiratory infection model, we have demonstrated previously that with Bordetella pertussis or immunization whole-cell vaccine induced antigen-specific Th1 cells, which conferred high level of protection against aerosol challenge. In contrast, an acellular vaccine, consisting the B. components detoxified toxin, filamentous hemagglutinin, and pertactin adsorbed to alum, generated Th2 cells was associated delayed bacterial clearance following this study, addition interleukin-12...
Abstract Despite recent advances, there is still a major need to better understand the interactions between brain function and chronic gut inflammation its clinical implications. Alterations in executive have previously been identified several inflammatory conditions, including bowel diseases. Inflammation-associated alterations can be captured by connectome analysis. Here, we used resting-state fMRI data from 222 participants comprising three groups (ulcerative colitis (UC), irritable...
We have used a murine respiratory challenge model to examine the local T cell responses in lung during infection with Bordetella pertussis. cells from parenchyma and airways of naive infected mice were refractory both antigen mitogen stimulation presence macrophages. Furthermore irradiated mononuclear lungs suppressed mitogen-induced proliferation, but not IFN-gamma production, by splenic cells. Removal macrophages purified antigen-presenting fully restored response mitogen. However, acute...
Introduction: Panniculectomy is recognized to have a high complication rate with up 56% of patients having postoperative wound healing problems. As they are generally elective procedures, surgeons the chance optimize preoperative variables. We reviewed relationship between serum albumin and BMI short-term panniculectomy complications. Methods: Patients undergoing January 2005 December 2019 were identified via CPT code 15830 from American College Surgeons National Surgical Quality Improvement...
Conference Abstract| February 01 1997 The role of the S-1 and B-oligomer components pertussis toxin in its adjuvant properties for Th1 Th2 cells MARK S. RYAN; RYAN 1Infection Immunity Group, Department Biology, St Patrick's College, Maynooth, Co. Kildare, Ireland. Search other works by this author on: This Site PubMed Google Scholar FIONA GRIFFIN; GRIFFIN 2Infection BERNARD MAHON; MAHON 3Infection KINGSTON H. G. MILLS 4Infection Biochem Soc Trans (1997) 25 (1): 126S....
Conference Article| May 01 1997 Mechanisms of immunity to the respiratory pathogen Bordetella pertussis in normal and gene knockout mice: clearance primary infection is not enhanced by therapeutic interleukin-12 BERNARD P. MAHON; MAHON 1Infection Immunity Group, Department Biology, National University Ireland at Maynooth, Co. Kildare, Search for other works this author on: This Site PubMed Google Scholar MARK RYAN; RYAN FIONA GRIFFIN; GRIFFIN KINGSTON H.G. MILLS Biochem Soc Trans (1997) 25...
Conference Abstract| February 01 1997 Local cellular immunity to the respiratory pathogen Bordetella pertussis: role of costimulatory molecules PETER MC GUIRK; GUIRK 1Infection and Immunity Group, Department Biology, St Patrick's College, Maynooth, Co. Kildare, Ireland. Search for other works by this author on: This Site PubMed Google Scholar BERNARD P. MAHON; MAHON 2Infection FIONA GRIFFIN; GRIFFIN 3Infection KINGSTON H. G. MILLS 4Infection Biochem Soc Trans (1997) 25 (1): 124S....
Photo by Reproductive Health Supplies Coalition on Unsplash INTRODUCTION Emergency contraception is formally recognized as the only effective way to prevent pregnancy after sexual intercourse World Organization.[1] The word emergency used due brief time during which it efficacious. It useful when administered within 72 hours of a encounter.[2] When pharmacists withhold contraception, they permanently eliminate window opportunity in can take effect. If patients do not find another source may...
Photo by Renè Müller on Unsplash INTRODUCTION Forced sterilization of women around the globe is a human rights violation and bioethical concern. In past, countries enacted laws to forcibly sterilize deemed unfit procreate. Although many these have been retracted, practice persists under guise public health. More recently, living with HIV targets nonconsensual sterilization. Consent frequently obtained while duress or threat not at all. Nonconsensual has documented in Chile, Dominican...
Abstract Introduction Despite advances in medical therapies and surgical techniques, oesophagogastric cancer survival remains low. Poorer outcomes from colorectal have been reported for patients living areas of higher socioeconomic deprivation1. Our aim was to determine if deprivation affected North East Scotland. Methods A prospective, single-centre observation study conducted utilising data oesophago-gastric MDT referrals January 2013 December 2019. Patient postcodes were cross-referenced...
Abstract Introduction Despite advances in medical therapies and surgical techniques, oesophagogastric cancer survival remains low. Poorer outcomes for rural dwellers is well documented worldwide has been an area of focus Scotland since 2007, with changes to suspected referral guidelines a government report on delivering remote healthcare. Methods A prospective, single-centre observation study was conducted utilising data from oesophago-gastric MDT referrals January 2013 December 2019. The...