A5101753966- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Galectins and Cancer Biology
- Williams Syndrome Research
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Human Pose and Action Recognition
- Complement system in diseases
- Monoclonal and Polyclonal Antibodies Research
- Obstructive Sleep Apnea Research
- Multimodal Machine Learning Applications
- Metabolomics and Mass Spectrometry Studies
- Angiogenesis and VEGF in Cancer
- Telomeres, Telomerase, and Senescence
- Cancer-related molecular mechanisms research
- Hearing, Cochlea, Tinnitus, Genetics
- Tissue Engineering and Regenerative Medicine
- Firm Innovation and Growth
- Salivary Gland Tumors Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Cancer-related gene regulation
- Cytomegalovirus and herpesvirus research
- Cancer Genomics and Diagnostics
- Gene expression and cancer classification
National Heart Lung and Blood Institute
2012-2024
National Institutes of Health
2012-2024
Shenyang Anorectal Hospital
2024
Xiamen University of Technology
2024
Dalian Municipal Central Hospital
2020-2023
Beijing University of Posts and Telecommunications
2023
Beijing Research Institute of Mechanical and Electrical Technology
2023
The First Affiliated Hospital, Sun Yat-sen University
2020
Sun Yat-sen University
2020
University of Michigan
2020
Genetic defects in telomere maintenance and repair cause bone marrow failure, liver cirrhosis, pulmonary fibrosis, they increase susceptibility to cancer. Historically, androgens have been useful as treatment for failure syndromes. In tissue culture animal models, sex hormones regulate expression of the telomerase gene.In a phase 1-2 prospective study involving patients with diseases, we administered synthetic hormone danazol orally at dose 800 mg per day total 24 months. The goal was...
Abstract Treatment of chronic lymphocytic leukemia (CLL) has shifted from chemo-immunotherapy to targeted agents. To define the evolutionary dynamics induced by therapy in CLL, we perform serial exome and transcriptome sequencing for 61 ibrutinib-treated CLLs. Here, report clonal shifts (change >0.1 cancer cell fraction, Q < 0.1) 31% patients during first year therapy, associated with adverse outcome. We also observe transcriptional downregulation pathways mediating energy metabolism,...
Proteasome inhibition disrupts protein homeostasis and induces apoptosis. Up to 50% of patients with relapsed mantle cell lymphoma (MCL) respond bortezomib. We used gene expression profiling investigate the connection between proteasome inhibition, cellular response, clinical efficacy.
Abstract Aims With increasing prevalence of heart failure (HF) owing to the ageing population, identification modifiable risk factors is important. In a mouse model, chronic hypohydration induced by lifelong water restriction promotes cardiac fibrosis. Hypohydration elevates serum sodium. Here, we evaluate association sodium at middle age as measure hydration habits with develop HF. Methods and results We analysed data from Atherosclerosis Risk in Communities study enrolment (45–66 years) 25...
Abstract In chronic lymphocytic leukemia (CLL), B-cell receptor signaling, tumor–microenvironment interactions, and somatic mutations drive disease progression. To better understand the intersection between microenvironment molecular events in CLL pathogenesis, we integrated bulk transcriptome profiling of paired peripheral blood (PB) lymph node (LN) samples from 34 patients. Oncogenic processes were upregulated LN compared with PB immunoglobulin heavy-chain variable (IGHV) region unmutated...
Hepatic lipogenesis is the principal route to convert excess carbohydrates into fatty acids and mainly regulated by two opposing hormones, insulin glucagon. Although stimulates hepatic lipogenesis, glucagon inhibits it. However, mechanism which suppresses remains poorly understood. In this study, we have observed that p38 mitogen-activated protein kinase plays an inhibitory role in lipogenesis. Levels of plasma triglyceride accumulation liver were both elevated when activation was blocked....
Increased vascular stiffness correlates with a higher risk of cardiovascular complications in aging adults. Elastin (ELN) insufficiency, as observed patients Williams-Beuren syndrome or familial supravalvular aortic stenosis, also increases and leads to arterial narrowing. We used Eln
Abstract Chronic lymphocytic leukemia (CLL) is a malignancy of mature B cells driven by B-cell receptor (BCR) signaling and activated primarily in the lymph node. The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib effectively inhibits BCR-dependent proliferation survival signals has emerged as breakthrough therapy for CLL. However, complete remissions are uncommon achieved only after years continuous therapy. We hypothesized that other pathways sustain CLL cell partially inhibited...
Abstract The clinical efficacy displayed by ibrutinib in chronic lymphocytic leukemia (CLL) has been challenged the frequent emergence of resistant clones. target, Bruton's tyrosine kinase (BTK), is essential for B-cell receptor signaling, and most cases carry mutations BTK or PLCG2, a downstream effector target BTK. Recent findings show that MI-2, small molecule inhibitor para-caspase MALT1, effective preclinical models another type BCR pathway–dependent lymphoma. We therefore studied...
Abstract Williams–Beuren syndrome (WBS) is a multisystem disorder caused by hemizygous deletion on 7q11.23 encompassing 26–28 genes. An estimated 2–5% of patients have “atypical” deletions, which extend in the centromeric and/or telomeric direction from WBS critical region. To elucidate clinical differentiators among these types, we evaluated 10 individuals with atypical deletions our cohort and 17 similarly classified previously described literature. Larger either often led to more severe...
Abstract Immune stimulation contributes to lenalidomide’s antitumor activity. Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of mature, autoreactive B cells in secondary lymphoid tissues, blood, and bone marrow progressive immune dysfunction. Previous studies CLL indicated that lenalidomide can repair defective T cell function vitro. Whether activation required for clinical response remains unclear. In this study, we report changes microenvironment patients with...
Cutaneous disease in dermatomyositis has no standardized treatment approach and so presents a challenging task for patients clinicians.To study the efficacy safety of apremilast as an add-on therapy with recalcitrant cutaneous dermatomyositis.This phase 2a, open-label, single-arm nonrandomized controlled trial was conducted at single center from June 2018 to 2021. Participants were 8 dermatomyositis, defined by activity severity index (CDASI) score greater than 5 despite steroids,...
We propose a nonlinear regression model for quantitatively analyzing periodic gene expression in studies of experimentally synchronized cells. Our accounts the observed attenuation cycle amplitude by simple and biologically plausible mechanism. represent level each as an average across large number For given cell-cycle gene, we its cell culture following same sinusoidal function except that period, which any individual must be all genes, varies randomly these random periods using lognormal...
An assay proposed to quantify endothelial progenitor cell (EPC) colonies in humans was investigated determine the phenotype of recovered cells and their relevance vivo function.Twelve sedentary subjects participating a worksite wellness program underwent flow-mediated dilation (FMD) testing brachial artery blood sampling for EPC colony assay. Microarray-based genotypic characterization showed surface markers consistent with T lymphocyte phenotype, but not an (CD34, CD133, VEGFR-2) or (CD146)...
It is well recognized that there sex-dimorphic expression of mRNA and protein in the heart; however, underlying mechanism poorly understood. Endothelial nitric oxide synthase (eNOS) an important regulator cardiac function, levels eNOS differ between male female hearts. The aim this study was to examine whether specific microRNA (miRNA, miR) males females contributes changes eNOS. miRNA extracted from myocardium C57BL/6 mice subjected Affymetrix array. Decreased miR-222 discovered confirmed...
Abstract Twenty‐eight synovial effusions (SE) were obtained from 24 patients, paired samples of peripheral blood (PB) 10 these and PB 36 healthy individuals for analysis CD146 on T‐lymphocytes by flow cytometry. CD146+ or CD146− sorted three SE to study gene expression profiles selected genes revalidated using QPCR assays. We found more CD3+CD146+ CD4+CD146+ in patients compared with (4.71% ± 2.48% vs. 2.53% 1.08%, P = 0.028) (6.29% 2.74% 2.41% 0.96%, 0.0017), respectively, whereas...
Supravalvular aortic stenosis (SVAS) is a narrowing of the aorta caused by elastin (ELN) haploinsufficiency. SVAS severity varies among patients with Williams-Beuren syndrome (WBS), rare disorder that removes one copy ELN and 25-27 other genes. Twenty percent children WBS require or more invasive often risky procedures to correct defect while 30% have no appreciable stenosis, despite sharing same basic genetic lesion. There known medical therapy. Consequently, identifying genes modify offers...
There are more than 7000 described rare diseases, most lacking specific treatment. Autosomal-dominant hyper-IgE syndrome (AD-HIES, also known as Job's syndrome) is caused by mutations in STAT3. These patients present with immunodeficiency accompanied severe nonimmunological features, including skeletal, connective tissue, and vascular abnormalities, poor postinfection lung healing, subsequent pulmonary failure. No therapies available for these abnormalities. Here, we investigated underlying...
Background Supravalvar aortic stenosis (SVAS) is a characteristic feature of Williams–Beuren syndrome (WBS). Its severity varies: ~20% people with have SVAS requiring surgical intervention, whereas ~35% no appreciable SVAS. The remaining individuals intermediate severity. Little known about genetic modifiers that contribute to this variability. Methods and Results We performed genome sequencing on 473 developed strategies for modifier discovery in rare disease population. Approaches include...
Recent circadian clock studies using gene expression microarray in two different tissues of mouse have revealed not all circadian-related genes are synchronized phase or peak times across vivo. Instead, some may be delayed by 4-8 hrs one tissue relative to the other. These interesting biological observations prompt a statistical question regarding how distinguish from that systematically lagged phase/peak time tissues.We propose set techniques circular statistics analyze angles tissues. We...