Benjamin Wooden
A5012320419- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Chronic Lymphocytic Leukemia Research
- Vasculitis and related conditions
- Complement system in diseases
- Autoimmune Bullous Skin Diseases
- Systemic Lupus Erythematosus Research
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Cell Adhesion Molecules Research
- Genomics and Rare Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Lymphatic Disorders and Treatments
- Phagocytosis and Immune Regulation
- Liver Disease and Transplantation
- Bioinformatics and Genomic Networks
- Platelet Disorders and Treatments
- Liver physiology and pathology
- BRCA gene mutations in cancer
- Gene expression and cancer classification
- Diabetes and associated disorders
- Neurological and metabolic disorders
- Cancer Genomics and Diagnostics
- Biomedical Research and Pathophysiology
- Liver Diseases and Immunity
Columbia University Irving Medical Center
2022-2025
Columbia University
2022-2025
Icahn School of Medicine at Mount Sinai
2016-2017
African Americans have a significantly higher risk of developing chronic kidney disease, especially focal segmental glomerulosclerosis -, than European Americans. Two coding variants (G1 and G2) in the APOL1 gene play major role this disparity. While 13% carry high-risk recessive genotypes, only fraction these individuals develops FSGS or failure, indicating involvement additional disease modifiers. Here, we show that presence p.N264K missense variant, when co-inherited with G2 allele,...
Abstract We have used a computational approach to identify anti-fibrotic therapies by querying transcriptome. A transcriptome signature of activated hepatic stellate cells (HSCs), the primary collagen-secreting cell in liver, and queried against transcriptomic database that quantifies changes gene expression response 1,309 FDA-approved drugs bioactives (CMap). The flavonoid apigenin was among 9 top-ranked compounds predicted activity; indeed, dose-dependently reduced collagen I human HSC...
Key Points We conducted a clinical, genetic, and pathological analysis on 64 cases from 39 families with TRPC6-associated podocytopathy (TRPC6-AP). Analysis of 37,542 individuals excluded major contribution loss-of-function variants to TRPC6-AP, legitimating current drug discovery approaches. This study identifies key features disease that can help intervention studies design suggests similarities between TRPC6-AP primary FSGS. Background Understanding the genetic basis human diseases has...
Introduction: ANCA-associated vasculitis (AAV) and lupus nephritis (LN) are distinct disease processes that both cause a nephritic picture with acute renal failure, but have different pathophysiologies thus treatment strategies. They also characteristic phenotypes on biopsy. Rarely, the two can coincide in one patient, known as AAV-LN overlap syndrome. Case Presentation: We present case of 78 year old woman who presented rapidly progressive failure Initial workup suggested AAV, further...
Abstract Background and hypothesis Adult pediatric patients with nephrotic syndrome (NS) due to different glomerular diseases are at a higher risk of thromboembolic events than the general population, but use prophylactic anticoagulation (PAC) among them has not been well described. Although Kidney Disease: Improving Global Outcomes (KDIGO) 2021 guidelines offer an algorithm guide management PAC, degree their implementation in practice is unknown. Methods We evaluated thromboprophylaxis NS...
ABSTRACT Black Americans have a significantly higher risk of developing chronic kidney disease (CKD), especially focal segmental glomerulosclerosis (FSGS), than European Americans. Two coding variants (G1 and G2) in the APOL1 gene play major role this disparity. While 13% carry high-risk recessive genotypes, only fraction these individuals develops FSGS or failure, indicating involvement additional modifiers. Here, we show that presence p.N264K missense variant, when co-inherited with G2...
Journal of the American Society Nephrology 33(11S):p 744, November 2022. | DOI: 10.1681/ASN.20223311S1744a