A5033760233- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Diet, Metabolism, and Disease
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis Viruses Studies and Epidemiology
- Hepatitis C virus research
- Systemic Lupus Erythematosus Research
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- IgG4-Related and Inflammatory Diseases
- SARS-CoV-2 and COVID-19 Research
- Biomedical Research and Pathophysiology
- Poisoning and overdose treatments
- Lysosomal Storage Disorders Research
- Pancreatic function and diabetes
- Dermatology and Skin Diseases
- COVID-19 Clinical Research Studies
- Inflammatory mediators and NSAID effects
- Vitamin C and Antioxidants Research
- Gastrointestinal disorders and treatments
- Pharmacogenetics and Drug Metabolism
- Alcohol Consumption and Health Effects
- Lipid metabolism and disorders
Moscow Clinical Scientific Center
2016-2025
Autoimmune Technologies (United States)
2023
Moscow State University of Medicine and Dentistry
2020
BACKGROUND Noninvasive tests are crucial for the management and follow-up of patients with autoimmune hepatitis, but their validation is limited because insufficient data. AIM To investigate diagnostic performance three fibrosis noninvasive [FibroTest, vibration-controlled transient elastography (VCTE), fibrosis-4 index (FIB-4) two activity biomarkers (alanine aminotransferase (ALT) ActiTest]. METHODS This study enrolled 103 whom liver biopsy, hepatic results, laboratory markers were...
Non-alcoholic fatty liver disease (NAFLD) is the first most common worldwide. In fact, NAFLD associated with metabolic syndrome (MS) and a certain phenotype that has developed as result of combined action complex heterogeneous etiological factors. A feature this its extreme heterogeneity, which raises demand for classification, would help to distinguish between supposedly metabolically favorable unfavorable subtypes. The task international consortium expert group was integrate modern ideas...
Aim. To estimate the incidence of hepatic steatosis (HS) and liver fibrosis (LF) in patients with diabetes mellitus (DM), by applying noninvasive techniques fibroelastometry (LFE) a battery fibrotests (FTs); to determine their diagnostic value identify factors influencing development LF. Subjects methods. A comprehensive examination was made 82 diabetic (mean age, 56.7±12.7 years; p=0.033). The data were statistically evaluated using ROC curve analysis, correlation single-factor analyses...
Background. Despite active research, drug treatment options for metabolic associated fatty liver disease (MAFLD) are limited, and there no currently approved drugs patients with MAFLD. Treatment of at risk developing non-alcoholic steatohepatitis progressive fibrosis (LF) is particular relevance, since they determine the clinical outcomes disease.
 Aim. To evaluate efficacy complex polypeptide (CPD), human placenta hydrolyzate, containing low molecular weight regulatory peptides, amino...
Background. Despite the well-studied pathogenesis, etiology of autoimmune liver disease (AILD) remains unknown. Aim. To determine significance hepatitis A, B, C and E viruses in development progression AILD. Materials methods. A single-center case-control study included 139 patients with AILD: AIH (n=46), primary biliary cholangitis PBS (n=74), sclerosing PSC (n=19). Median age 56 years, IQR 4865 years. 125 without control group (median 55 4665 years). Testing blood serum samples for...
The article is published based on the results of Russian Consensus diagnosis and treatment primary sclerosing cholangitis (PSC), discussed at 44th annual Scientific Session CNIIG "Personalized Medicine in Era Standards" (March 1, 2018). aim review to highlight current issues classification patients with PSC, which causes greatest interest specialists. urgency problem determined by multivariate nature clinical manifestations, often asymptomatic flow, severe prognosis, complexity insufficient...
e severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of new Coronavirus disease 2019 , has been posing a serious threat to public health worldwide.Currently, COVID-19 is considered be systemic that impairs immune system function body, primarily ecting lungs, as well heart, kidneys, intestines, liver and spleen.Liver injury occurs mainly in COVID-19.At present, it remains unclear whether changes laboratory parameters found patients with are sign pre-existing...
Александрова Е.Н
To assess the diagnostic accuracy of controlled attenuation parameter (CAP) to determine grade hepatic steatosis (HS) in patients with chronic liver diseases (CLD) different etiologies and compare obtained results morphological findings.A total 45 (18 men 27 women) aged 25 73 years CLD were examined. All underwent puncture biopsy for assessing HS index fibrosis stage, as well determination elasticity (F, kPa) estimating stage by CAP (S, dB/m) using a FibroScan device. When HS, values <229,...
Aim. To evaluate the frequency of liver fibrosis progression to stage 34 among patients with non-alcoholic fatty disease (NAFLD), type 2 diabetes and obesity, identify predictors severe fibrosis, propose an algorithm for diagnosing in this category patients. Materials methods. 160 NAFLD, mellitus (DM) obesity 50 NAFLD without were comprehensively examined. Patients underwent laboratory examination (clinical blood test, biochemical analysis, immunoglobulins G, M, autoantibody assay,...
Previous viral hepatitis B increases the risk of cirrhosis in various chronic liver diseases. Aim . Assessment association between previous and severity fibrosis patients with nonalcoholic fatty disease (NAFLD). Materials methods A single-centre cross-sectional trial included 110 HBsAg- anti-HCV-negative confirmed NAFLD (median (IQR) age 60 (53-66) years). Obesity, type 2 diabetes dyslipidemia were 78 (70.9%), 64 (58.2%) 77 (70%) individuals, respectively. To confirm occult virus (HBV)...
ГЕПАТОЛОГИЯПервичный билиарный холангит в эпоху урсодезоксихолевой кислоты: достижения и проблемы терапии Е.В.Винницкая 1 , К.Г.Абсандзе Е.В.Архипова А
Dyslipidemia is one of the main risk factors for development cardiovascular diseases (CVD), which remain leading cause death worldwide. Lipid level control most effective strategy prevention CVD and its complications (CVC). Statins are first-line drugs hypolipidemic therapy. often found in patients with chronic liver (CLD). From a clinical point view, number CLD have an increased CVD. Due to insufficient awareness doctors about possibilities using statin non-statin lipid-lowering therapy...
Autoimmune hepatitis (AIH) has all the characteristic signs of an autoimmune disease, a variability clinical manifestations, depending on age, gender, presence concomitant pathology, hormonal background, may differ in frequency immune-mediated diseases, serological profile, unequal response to immunosuppressive therapy (IST), have different variants onset, course and outcome disease. All this complicates diagnosis determines expediency isolating AIH phenotypes. The recognition phenotypes...
Lysosomal acid lipase deficiency (DLK) is an autosomal recessive disease caused by mutations in the LIPA gene. Cholesterol ester accumulation (BNEH) a clinical phenotype of DLCL characterized lysosomal (LCL) activity with residual enzymatic 1–5%, manifested at later age and slow progression (unlike main classical – Wolman's disease). As rule, even histological examination liver, such patients may be diagnosed non-alcoholic fatty liver (NAFLD), steatohepatitis (NASH) or cryptogenic disease....
Background. In the last decade, understanding of pathogenesis autoimmune hepatitis (AIH) has significantly deepened, based on results new clinical studies some diagnostic issues have been revised and immunosuppressive therapy regimens optimized. Materials methods. The latest Russian guidelines for diagnosis treatment AIH were presented in 2013; 2017, first agreement was held. Updating approaches to management patients with necessitated next systematization use practice. February 2024, final...
Aim : To raise the awareness of general practitioners with special characteristics clinical manifestations drug-induced liver injury (DILI), which can manifest various signs, symptoms and types morphological injury, from asymptomatic increase in transaminases steatosis to chronic hepatitis advanced fibrosis. Key points NSAID is one most commonly prescribed groups agents worldwide. Most them have low risk toxicity. However, prolonged uncontrolled intake by patients without proper medical...
Relevance: Non-alcoholic fatty liver disease is the most common worldwide. Although usually has a favorable, asymptomatic course, in some cases it can occur form of non-alcoholic steatohepatitis, and patients may develop cirrhosis hepatocellular carcinoma. There are more foreign studies proving relationship genetic factors with progression disease. However, information about this association Russian Federation remains scarce. Goal study: to assess prevalence patatinlike phospholipase...
The article describes the current views on pathogenesis of nonalcoholic fatty liver disease and a short overview possible methods therapy. main mechanisms antioxidant action ademetionine in treatment NAFLD analysis evidence base its effectiveness are discussed. We present clinical cases positive impact patients.
Antinuclear antibodies (ANA) are a heterogeneous group of autoantibodies that react with various components the cell nucleus and cytoplasm. ANA is main serological marker for autoimmune liver disease (AILD). The aim study was to compare diagnostic value two methods screening determination (indirect immunofluorescence reaction on HEp-2 cells (IIF -HEp-2) enzyme-linked immunosorbent assay (ELISA) in sera AILD patients. 118 patients (51 hepatitis - AIH, 19 primary biliary cholangitis PBC, 48...