A5078575387- Galectins and Cancer Biology
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Ubiquitin and proteasome pathways
- Signaling Pathways in Disease
- Glaucoma and retinal disorders
- Macrophage Migration Inhibitory Factor
- Cancer-related Molecular Pathways
- Nerve injury and regeneration
- Neonatal and fetal brain pathology
- Mitochondrial Function and Pathology
- Axon Guidance and Neuronal Signaling
- Alzheimer's disease research and treatments
- Protein Tyrosine Phosphatases
- Genetics and Neurodevelopmental Disorders
- Immune cells in cancer
- Ophthalmology and Eye Disorders
- Retinal Diseases and Treatments
- Neuroscience and Neuropharmacology Research
- Cell death mechanisms and regulation
- Inflammation biomarkers and pathways
- Amino Acid Enzymes and Metabolism
- Multiple Sclerosis Research Studies
- Neurological Disease Mechanisms and Treatments
- Magnesium Alloys: Properties and Applications
Consejo Nacional de Investigaciones Científicas y Técnicas
2013-2025
University of Buenos Aires
2014-2025
Instituto de Química y Fisicoquímica Biológicas
2014-2025
Abstract Glaucoma is a leading cause of blindness, characterized by retinal ganglion cell ( RGC ) loss and optic nerve ON damage. Cumulative evidence suggests glial involvement in the degeneration s. We analyzed contribution microglial reactivity to early axoglial alterations an induced model ocular hypertension. For this purpose, vehicle or chondroitin sulfate CS were weekly injected into eye anterior chamber from Wistar rats for different intervals. The amount Brn3a(+) significantly...
The multicatalytic protease complex or proteasome is a fundamental nonlysosomal tool that the cell uses to process degrade proteins at fast rate through ubiquitin and ATP-dependent proteolytic pathway. Examples of these important include tumor suppressor protein p53, various cyclins, cyclin-dependent kinase inhibitor p27, NFkappaB, IkappaB, c-fos, c-jun. activation enzymes, including certain cystein-proteases ced-3/ICE (interleukin-1beta-converting enzyme) family, characteristic feature...
Diabetic retinopathy is a leading cause of acquired blindness. Visual function disorders have been observed in diabetic patients with very early or even before the onset retinopathy. The aim present work was to analyze visual pathway an stage experimental diabetes. Diabetes induced Wistar rats by i.p. injection streptozotocin. A deficit anterograde transport from retina superior colliculus 6 weeks after streptozotocin injection. At this time point, morphologic studies did not reveal retinal...
Multiple sclerosis (MS) is one of the most common causes progressive disability affecting young people with very few therapeutic options available for its forms. Its pathophysiology involves demyelination and neurodegeneration apparently driven by microglial activation, which physiologically dependent on colony-stimulating factor-1 receptor (CSF-1R) signaling. In present work, we used modulation through oral administration brain-penetrant CSF-1R inhibitor BLZ945 in acute chronic cuprizone...
Abstract Our previous studies showed that the intracerebral injection of apotransferrin (aTf) attenuates white matter damage and accelerates remyelination process in a neonatal rat model cerebral hypoxia‐ischemia (HI) injury. However, aTf might not be practical for clinical treatments. Therefore, development less invasive techniques capable delivering to central nervous system would clearly aid its effective use. In this work, we have determined whether intranasal (iN) administration human...
Early life stress (ELS), a prenatal/early postnatal period of severe trauma, social deprivation, or neglect, among other adversities, constitutes risk factor for developing psychopathologies and different health complications in adulthood. Maternal separation with early weaning (MSEW) induces long-term consequences mouse retinal function structure. We analyzed microglia involvement adult retina ELS-induced sequelae. C57Bl/6 J mice were separated from the dams at days (PND) 4-6, 7-9, 10-12,...
We have previously demonstrated that aTf (apotransferrin) accelerates maturation of OLs (oligodendrocytes) in vitro as well vivo. The purpose this study is to determine whether plays a functional role model H/I (hypoxia/ischaemia) the neonatal brain. Twenty-four hours after insult, rats were intracranially injected with and effects treatment evaluated CC (corpus callosum) SVZ (subventricular zone) at different time points. Similar previous studies, event produced severe demyelination CC....
Changes of neurosteroids may be involved in the pathophysiology multiple sclerosis (MS). The present study investigated whether changes neurosteroidogenesis also occurred grey and white matter regions brain mice subjected to cuprizone‐induced demyelination. Accordingly, we compared expression neurosteroidogenic proteins, including steroidogenic acute regulatory protein (StAR), voltage‐dependent anion channel (VDAC) 18 kDa translocator (TSPO), as well enzymes, side chain cleavage enzyme...