A5084966105- Neuroscience and Neuropharmacology Research
- Medicinal Plant Extracts Effects
- Medicinal Plants and Neuroprotection
- Phytochemistry and Biological Activities
- Synthesis of Organic Compounds
- Cholinesterase and Neurodegenerative Diseases
- Attention Deficit Hyperactivity Disorder
- Synthesis and biological activity
- Photochromic and Fluorescence Chemistry
- Natural product bioactivities and synthesis
- Chemical Reaction Mechanisms
- Alkaloids: synthesis and pharmacology
- Computational Drug Discovery Methods
- Biochemical Analysis and Sensing Techniques
- Macrophage Migration Inhibitory Factor
- Epilepsy research and treatment
- Phenothiazines and Benzothiazines Synthesis and Activities
- Biological Activity of Diterpenoids and Biflavonoids
- Pain Mechanisms and Treatments
- Migraine and Headache Studies
- Bioactive natural compounds
- Phytochemicals and Antioxidant Activities
- Galectins and Cancer Biology
- Piperaceae Chemical and Biological Studies
- Neurological Disease Mechanisms and Treatments
Instituto de Química y Fisicoquímica Biológicas
2011-2024
University of Buenos Aires
2013-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2009-2024
University of Palermo
2014
University of Strathclyde
1996
Instituto de Biología Molecular y Celular de Rosario
1996
Stanford University
1984
University at Albany, State University of New York
1984
University of California, Santa Barbara
1984
The list of activities plant flavonoids did not include effects on the central nervous system (CNS) up to 1990, when our laboratory described existence natural anxiolytic flavonoids. first these was chrysin (5,7-dihydroxyflavone), followed by apigenin (5,7,4'-trihydroxyflavone) and flavone itself. Semisynthetic derivatives obtained introducing halogens, nitro groups or both in its molecule, give rise high affinity ligands for benzodiazepine receptor, active in-vivo; 6,3'-dinitroflavone,...
Anxiety disorders, depression and pain are highly prevalent pathologies. Their pharmacotherapy is associated with unwanted side effects; hence there a clinical need to develop more effective drugs fewer adverse reactions. Chalcones one of the major classes naturally occurring compounds. their derivatives have huge importance in medicinal chemistry, displaying wide range pharmacological activities including anti-inflammatory, antimicrobial, antioxidant, cytotoxic antitumor actions. The aim...
The resurgence of interest in monoamine oxidases (MAOs) has been fueled by recent correlations this enzymatic activity with cardiovascular, neurological, and oncological disorders. This promoted increased research into selective MAO-A MAO-B inhibitors. Here, we shed light on how inhibition can be achieved geometric isomers cis- trans-1-propargyl-4-styrylpiperidines. While the cis are potent human inhibitors, trans analogues selectively target only isoform. was studied kinetic analysis,...
Using the guidance by a competitive assay for benzodiazepine binding site in GABA(A) receptor, active compounds were isolated from rhizomes and roots of Valeriana wallichii DC. The UV, NMR mass spectral data permitted identification 6-methylapigenin. This flavonoid has Ki = 495 nM BDZ-bs GABA ratio 1.6-2.0, which suggests possible agonistic properties. calculated percentage 6-methylapigenin crude drug is range: 0.013% to 0.0013%.
A mathematical model of the periodic, rippled P beta' phase phosphatidylcholine is described. In this shows a periodic variation in membrane properties corresponding to lateral between fluid-like and crystal-like states. The based on curvature-dependent Landau-de Gennes free-energy functional. Our proposed form free energy remedies subtle flaw an earlier having similar physical content [Falkovitz, M. F., Seul, M., Frisch, H. L. & McConnell, (1982) Proc. Natl. Acad. Sci. USA 79, 3918-3921].
Stevia rebaudiana Bertoni, widely recognized for its natural sweetening properties, contains bioactive compounds such as stevioside (STV), which exhibit significant and multiple health benefits. This study explores the anticonvulsant properties of STV underlying mechanisms using in vitro vivo epilepsy models, focusing on antioxidant neuroprotective actions. In SH-SY5Y neuronal cultures, (10-100 μM) reversed pentylenetetrazol (PTZ)-induced damage without affecting cell viability significantly...