A5049886792- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Cystic Fibrosis Research Advances
- Inhalation and Respiratory Drug Delivery
- Allergic Rhinitis and Sensitization
- Pediatric health and respiratory diseases
- Sinusitis and nasal conditions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Dysphagia Assessment and Management
- Pneumonia and Respiratory Infections
- Neonatal Respiratory Health Research
- Respiratory viral infections research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Eosinophilic Esophagitis
- Obstructive Sleep Apnea Research
- Health and Medical Studies
- Delphi Technique in Research
- SARS-CoV-2 and COVID-19 Research
- Otitis Media and Relapsing Polychondritis
- Medical research and treatments
- COVID-19 Clinical Research Studies
- Drug-Induced Adverse Reactions
- Medication Adherence and Compliance
- Pneumothorax, Barotrauma, Emphysema
- Pharmaceutical studies and practices
Hospital Universitario de La Princesa
2015-2025
Universidad Autónoma de Madrid
2015-2020
Intensive Care Society
2020
State Duma
2017
Universitat de Barcelona
2015
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2015
The efficacy of mepolizumab is well documented in severe eosinophilic asthma (SEA), although the stringent selection criteria adopted by SEA clinical trials limits generalizability results. Our study evaluated effectiveness and safety patients with Spain. primary endpoint was change rate clinically significant exacerbations 12 months after starting compared to baseline prior treatment. Patients were stratified blood eosinophil counts. We conducted a multicentric observational cohort treated...
Severe asthma is a heterogeneous syndrome with several clinical variants and often represents complex disease requiring specialized multidisciplinary approach, as well the use of multiple drugs. The prevalence severe varies from one country to another, it estimated that 50% these patients present poor control their disease. For best management patient, necessary correct diagnosis, an adequate follow-up undoubtedly offer available treatment, including biologic treatments monoclonal...
Background: Some patients with COPD may share characteristics of asthma; this is the so-called asthma–COPD overlap syndrome (ACOS). There are no universally accepted criteria for ACOS, and most treatments asthma have not been adequately tested in population. Materials methods: We performed a survey among pulmonology specialists aimed at collecting their opinions about ACOS attitudes regard to some case scenarios patients. The participants answered structured questionnaire attended...
El asma grave constituye un síndrome heterogéneo con múltiples variantes clínicas y representa el último peldaño en la patología asmática relación su gravedad. La prevalencia del entre los pacientes asmáticos varía de país a otro, se estima que 50% estos graves tienen mal control enfermedad. Para mejor manejo paciente es necesario correcto diagnóstico, seguimiento sin duda ofrecerle tratamiento disponible, incluyendo nuevos avances farmacológicos, como son anticuerpos monoclonales. Con este...
Abstract: Chronic airflow obstruction affects a wide range of airway diseases, the most frequent which are asthma, COPD, and bronchiectasis; they clearly identifiable in their extremes, but quite frequently overlap some pathophysiological clinical characteristics. This has generated description new mixed or overlapping disease phenotypes with no clear biological grounds. In this special article, group experts provides perspective proposes approaching treatment chronic (CAD) through...
This study aimed to validate a 15-item screening questionnaire for the early detection of coexisting type 2 (T2) inflammatory diseases, such as asthma, atopic dermatitis, and chronic rhinosinusitis with nasal polyps (CRSwNP), among others. The questionnaire, designed through expert consensus by scientific committee, underwent Delphi methodology validation. A multidisciplinary panel 19 clinicians from different specialties reviewed clinical relevance, while 39 patients regions Spain evaluated...
Patient-physician opinion concordance could play a key role in asthma control. There have been no studies evaluating this association large samples of patients.To determine between patients and their pulmonologists on the impact disease to correlate control.This was cross-sectional multicentre study including 1160 300 pulmonologists. rates were assessed by two semi-structured qualitative questionnaires: (1) (2) treatment satisfaction. Subsequently, participating determined perceptions...
Pulmonary exacerbation is one of the main risk factors for death in patients with cystic fibrosis. Several biomarkers have proven useful diagnosis and treatment pulmonary exacerbations, although none has been associated severity. The objective present study was to investigate whether C-reactive protein (CRP) level severity requiring admission hospital fibrosis.We designed a index exacerbations based on 4 clinical parameters determined there an association between CRP levels exacerbation. We...
Abstract: This paper, developed by consensus of staff physicians accredited asthma units for the management severe asthma, presents information on process and requirements already-existing to achieve official accreditation Spanish Society Pneumology Thoracic Surgery (SEPAR). Three levels specialized care have been established based available resources, which include highly complex units, basic units. Regardless level obtained, distinction "excellence" could be granted when more in areas...
Dysregulation of type 2 (T2) immune response leads to an aberrant inflammatory reaction that constitutes the pathophysiological basis diseases involving various organs. For this reason, several disorders can coexist in a single patient; however, as different specialists often treat these pathologies, T2 dysregulation, particularly when mild, is not always first diagnostic suspicion. A breakdown interdisciplinary communication or lack adequate tools detect entities delay diagnosis, and this,...
Asthma with airway mucus hypersecretion is an inadequately characterized variant of asthma. While several studies have reported that hypersecreting patients may carry genetic variants in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, many those been questioned for their numerous limitations and contradictory results.(1) To determine presence CFTR gene asthma without hypersecretion. (2) identify clinical, inflammatory functional characteristics phenotype...
Abstract Background Scientific evidence on patients with multimorbid type 2 asthma and chronic rhinosinusitis nasal polyps (CRSwNP) from a united airways disease (UAD) perspective remains scarce, despite the frequent coexistence of these entities. We aimed to generate expert consensus-based recommendations for management UAD patients. Methods Using two-round Delphi method, Spanish allergists, pulmonologists otolaryngologists expressed their agreement 32 statements (52 items) 9-point Likert...
ABSTRACT Rationale Biologics are becoming increasingly important in the management of severe asthma. However, little is known about systemic immunometabolic consequences Th2 response blockage. Objectives To provide a better understanding effects mepolizumab and omalizumab treatments by identifying potential biomarkers for monitoring. Methods In this exploratory longitudinal study asthmatic patients were followed 18 months after initiating ( n = 36) or Omalizumab 20) treatment. Serum samples...