Manuel J. Rial
A5102854329- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Food Allergy and Anaphylaxis Research
- Contact Dermatitis and Allergies
- Dermatology and Skin Diseases
- Delphi Technique in Research
- Occupational exposure and asthma
- MicroRNA in disease regulation
- Drug-Induced Adverse Reactions
- Urticaria and Related Conditions
- Occupational Health and Safety Research
- Neonatal Respiratory Health Research
- Eosinophilic Esophagitis
- Pharmaceutical studies and practices
- Pediatric health and respiratory diseases
- Extracellular vesicles in disease
- Respiratory Support and Mechanisms
- Inhalation and Respiratory Drug Delivery
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- Bone and Joint Diseases
- Occupational and environmental lung diseases
- IL-33, ST2, and ILC Pathways
Complexo Hospitalario Universitario A Coruña
2016-2025
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2018-2025
Instituto de Salud Carlos III
2018-2024
Universidade da Coruña
2020-2024
Instituto de Investigación Biomédica de A Coruña
2024
Hospital La Paz Institute for Health Research
2019-2023
Hospital San Juan de la Cruz
2022-2023
Hospital Universitario La Paz
2023
Hospital Clínic de Barcelona
2023
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2023
There is a lack of consensus over the description and severity assignment allergic adverse reactions to immunotherapy, although there seems be at least in terms using World Allergy Organization (WAO) grading systems describe local events for Sublingual Immunotherapy (SLIT) Systemic Allergic Reactions (SARs) Subcutaneous (SCIT) amongst major national/regional allergy societies. In this manuscript, we propose modification previous WAO Grading system SARs, which aligns with newly-proposed...
Asthma is a syndrome characterized by airway inflammation and obstruction. Due to its heterogeneity, the difficulties in asthma diagnosis treatment make discovery of new biomarkers focus research. So, we determined differential miRNA expression eosinophils between healthy asthmatic patients establish differentially expressed profile detectable sera for use as biomarker.MicroRNAs from peripheral subjects were isolated analyzed next-generation sequencing confirmed quantitative PCR 29...
Clinical Implications•This study aimed to determine the rate of severe acute respiratory syndrome coronavirus 2 infection in Spanish patients with asthma under biological treatment and examine whether rates severity differ among several antiasthma drugs between without biologicals. With data from this cohort, we hypothesize that for uncontrolled does not represent a risk factor disease 2019 or its there are no significant differences different biologic used. •This On March 11, 2020, World...
Eosinophil-related diseases represent a group of pathologic conditions with highly heterogeneous clinical presentation and symptoms ranging from mild to critical. Both systemic localized forms disease are typically treated glucocorticoids. The approval novel biologic therapies targeting the interleukin-5 pathway can help reduce use glucocorticoids (SGC) in eosinophilic risk SGC-related adverse effects (AEs). In this article, panel experts different medical specialties reviewed current...
Abstract Background Benralizumab, a monoclonal antibody targeting the human interleukin-5 (IL-5) receptor (IL-5R), was used before marketing authorisation in Spain real world setting as part of an early-access programme (EAP) to treat patients with severe eosinophilic asthma prior insufficient response or intolerance anti-IL5 treatment (mepolizumab reslizumab). The objective this study is describe patient profile candidate for and assess benralizumab effectiveness. Methods This...
There is currently enough evidence to think that miRNAs play a role in several key points asthma, including diagnosis, severity of the disease, and response treatment. Cells release different types lipid double-membrane vesicles into extracellular microenvironment, exosomes, which function as very important elements intercellular communication. They are capable distributing genetic material, mRNA, mitochondrial DNA, microRNAs (miRNAs). Serum miRNA screening was performed order analyze...
Severe eosinophilic asthma poses a serious health and economic problem, so new therapy approaches have been developed to control it, including biological drugs such as benralizumab, which is monoclonal antibody that binds IL-5 receptor alpha subunit depletes peripheral blood eosinophils rapidly. Biomarkers predict the response this drug are needed microRNAs (miRNAs) can be useful tools. This study was performed with fifteen severe asthmatic patients treated serum miRNAs were evaluated before...
Chronic rhinosinusitis with nasal polyps (CRSwNP), which is characterized by partial loss of smell (hyposmia) or total (anosmia), commonly associated asthma and/or nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD). CRSwNP worsens severity and quality life. The objective this real-world study was to determine whether biological treatments prescribed for severe can improve olfaction in patients CRSwNP. A further compare the improvement N-ERD non-N-ERD subgroups.We...
<b><i>Background/Objective:</i></b> The objective of this study was to describe the molecular sensitization profile mite allergy in an area with a high environmental exposure house dust mites (HDM) and storage mites. <b><i>Methods:</i></b> Skin prick tests were performed standardized extracts (DIATER, Madrid, Spain). A specific commercial panel (MADx) for <i>Dermatophagoides pteronyssinus</i> (Dpt), farinae</i> (Dfar),...