André Guilherme Portela de Paula

ORCID: 0000-0003-4302-2296
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About
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Research Areas
  • Agricultural and Food Sciences
  • Bee Products Chemical Analysis
  • Phytochemistry Medicinal Plant Applications
  • Phytochemicals and Medicinal Plants
  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Impact on Reproduction
  • Immune cells in cancer
  • Gout, Hyperuricemia, Uric Acid
  • Diabetes and associated disorders
  • Pancreatic function and diabetes
  • COVID-19 Clinical Research Studies
  • Horticultural and Viticultural Research
  • Coronary Artery Anomalies
  • Banana Cultivation and Research
  • Plant Pathogens and Fungal Diseases
  • Amyotrophic Lateral Sclerosis Research
  • Immune Cell Function and Interaction
  • Pomegranate: compositions and health benefits
  • Pharmacological Effects and Assays
  • Biochemical Acid Research Studies
  • Inflammasome and immune disorders
  • Plant Physiology and Cultivation Studies
  • Electrospun Nanofibers in Biomedical Applications
  • Immune responses and vaccinations
  • Minerals Flotation and Separation Techniques

Universidade Federal do Paraná
2022-2025

UniBrasil Centro Universitário
2018-2021

Gout is a disease caused by uric acid (UA) accumulation in the joints, causing inflammation. Two UA forms - monosodium urate (MSU) and soluble (sUA) have been shown to interact physically with inflammasomes, especially nod-like receptor (NLR) family pyrin domain containing 3 (NLRP3), albeit role of immune response poorly understood, given that asymptomatic hyperuricemia does also exist. Macrophage phagocytosis activate NLRP3, lead cytokines release, ultimately, chemoattract neutrophils...

10.1080/08820139.2023.2168554 article EN Immunological Investigations 2023-02-06

Despite all efforts to combat the pandemic of COVID-19, we are still living with high numbers infected persons, an overburdened health care system, and lack effective definitive treatment. Understanding pathophysiology disease is crucial for development new technologies therapies best clinical management patients. Since manipulation whole virus requires a structure adequate level biosafety, alternative technologies, such as synthesis peptides from viral proteins, possible solution circumvent...

10.1038/s41598-023-29588-8 article EN cc-by Scientific Reports 2023-05-17

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that primarily affects motor neurons, leading to muscle weakness and eventual paralysis. Although the precise mechanisms driving ALS are not yet fully elucidated, emerging evidence suggests crucial role of neuroinflammation mitochondrial dysfunction in progression. Microglia, brain’s resident immune cells, play central neuroinflammatory response undergo metabolic reprogramming during ALS, shifting from homeostatic...

10.47191/ijmscrs/v4-i12-16 article EN cc-by International Journal of Medical Science and Clinical Research Studies 2024-12-26

Abstract Despite all efforts to combat the pandemic of COVID-19, we are still living with high numbers infected persons, an overburdened health care system, and lack effective definitive treatment. Understanding pathophysiology disease is crucial for development new technologies therapies best clinical management patients. Since manipulation whole virus requires a structure adequate level biosafety, alternative technologies, such as synthesis peptides from viral proteins, possible solution...

10.21203/rs.3.rs-2073995/v1 preprint EN cc-by Research Square (Research Square) 2022-10-17

A própolis é formada por material resinoso e balsâmico. É empregada pela humanidade para fins terapêuticos, pois possui ação anti-inflamatória, antibacteriana antioxidante. O objetivo deste trabalho foi avaliar o padrão de identidade qualidade quatro extratos hidroglicólicos produzidos com propilenoglicol água, através análises sensoriais (aroma, cor, sabor aspecto) físico-químicas (extrato seco, cera, flavonoides, compostos fenólicos, atividade oxidação, espectro absorção UV-Vis, acetato...

10.25192/issn.1984-7041.v20i15318 article PT cc-by-nc-sa Cadernos da Escola de Saúde 2021-08-05
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