A5058227452- Gut microbiota and health
- Diet and metabolism studies
- Nutritional Studies and Diet
- Diet, Metabolism, and Disease
- Probiotics and Fermented Foods
- Liver Disease Diagnosis and Treatment
- Consumer Attitudes and Food Labeling
- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Fatty Acid Research and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Inflammatory Bowel Disease
- Diabetes and associated disorders
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Food composition and properties
- Cardiovascular Disease and Adiposity
- Nuts composition and effects
- Cancer Research and Treatments
- Nutrition, Genetics, and Disease
- Biochemical Analysis and Sensing Techniques
- Clinical Nutrition and Gastroenterology
- Bone and Dental Protein Studies
- Digestive system and related health
Inserm
2020-2025
Université Paris Cité
2020-2025
Centre National de la Recherche Scientifique
2020-2025
Institut Pasteur
2025
Institut Cochin
2020-2023
Institut Universitaire de Cardiologie et de Pneumologie de Québec
2017-2022
Université Laval
2006-2022
Food Research Institute
2022
Montreal Heart Institute
2017-2021
Lung Institute
2019-2020
Background Accumulating evidence indicates that some non-absorbed food additives, including emulsifiers carboxymethylcellulose (CMC) and polysorbate 80 (P80), can negatively impact intestinal microbiota, leading to microbiota encroachment, chronic low-grade inflammation and, subsequently, promotion of metabolic dysregulations. Detrimental impacts emulsifier consumption on gut include depletion the health-associated mucus-fortifying bacteria, Akkermansia muciniphila . Objective Investigate,...
Animal models of human diseases are classically fed purified diets that contain casein as the unique protein source. We show provision a mixed source mirroring found in western diet exacerbates diet-induced obesity and insulin resistance by potentiating hepatic mTORC1/S6K1 signaling compared to alone. These effects involve alterations gut microbiota shown fecal transplantation studies. The detrimental impact is also linked with early changes microbial production branched-chain fatty acids...
Abstract Meta-analyses suggest that yogurt consumption reduces type 2 diabetes incidence in humans, but the molecular basis of these observations remains unknown. Here we show dietary intake preserves whole-body glucose homeostasis and prevents hepatic insulin resistance liver steatosis a mouse model obesity-linked diabetes. Fecal microbiota transplantation studies reveal effects are partly linked to gut microbiota. We further impacts metabolome, notably maintaining levels branched chain...
Metabolic syndrome is, in humans, associated with alterations the composition and localization of intestinal microbiota, including encroachment bacteria within colon's inner mucus layer. Possible promoters these events include dietary emulsifiers, such as carboxymethylcellulose (CMC) polysorbate-80 (P80), which, mice, result altered microbiota composition, encroachment, low-grade inflammation metabolic syndrome. While assessments gut have largely focused on fecal/luminal samples, we...
Given the growing evidence that gut dysfunction, including changes in microbiota composition, plays a critical role development of inflammation and metabolic diseases, identification novel probiotic bacteria with immunometabolic properties has recently attracted more attention. Herein, bacterial strains were first isolated from dairy products human feces then screened vitro for their immunomodulatory activity. Five selected further analyzed vivo, using mouse model diet-induced obesity....
The intestinal epithelial barrier (IEB) restricts the passage of microbes and potentially harmful substances from lumen through paracellular space, rupture its integrity is associated with a variety gastrointestinal disorders extra-digestive diseases. Increased IEB permeability has been linked to disruption metabolic homeostasis leading obesity type 2 diabetes. Interestingly, recent studies have uncovered compelling evidence that AMP-activated protein kinase (AMPK) signaling pathway plays an...
Dietary (poly)phenols are metabolized by intestinal microbiota, but their potential effect on gas production and gas-reated symptoms remain uncertain. The aim of this study was to correlate production, digestive sensations, gut microbiota composition, metabolites in urine feces upon consumption. Twenty-three healthy subjects consumed a (poly)phenol-rich berry mix for 18 days. initially increased anal evacuation induced gas-related which reverted days dietary administration, indicating that...
Selecting the most relevant control diet is of critical importance for metabolic and intestinal studies in animal models. Chow LF-purified differentially impact gut microbiome outcomes resulting major changes integrity LF-fed animals which contributes to altering homeostasis. Dietary fat low fiber both contribute deleterious effect purified HF diets through selective overlapping mechanisms.
Abstract We compared endogenous ω-3 PUFA production to supplementation for improving obesity-related metabolic dysfunction. Fat-1 transgenic mice, who endogenously convert exogenous ω-6 PUFA, and wild-type littermates were fed a high-fat diet daily dose of either or PUFA-rich oil 12 wk. The improved glucose intolerance insulin resistance but not hepatic steatosis. Conversely, fully prevented steatosis failed improve resistance. Both models increased levels PUFA-containing 2-monoacylglycerol...
We investigated the effect of yogurt consumption at 8% energy intake on insulin sensitivity in mice fed high-fat high-sucrose diet that contains a protein mixture representative US (HFHS-PM). Yogurt (2% fat, 5% protein, 7% carbohydrate, Lactobacillus bulgaricus CNCM I-1519, Streptococcus thermophilus I-1630) was lyophilized and incorporated into HFHS-PM (HFHS-PM + LYP; 4.8 kcal/g). The control group kept (4.8 A low-fat low sucrose (LFLS-PM; 3.7 Whole-body glucose homeostasis tissue action...
The tooth organ is extensively used in developmental biology to investigate organogenesis and cell differentiation. It also represents an advantageous system for the study of various cellular extracellular matrix events that regulate formation both collagenous noncollagenous calcified tissues. This article describes vivo surgical approach access experimentally manipulate supporting tissues rat incisor. By use a dental drill, “window” was created through alveolar bone on buccal aspect...
Oral antibiotic treatment is often applied in animal studies order to allow establishment of an introduced antibiotic-resistant bacterium the gut. Here, we compared application streptomycin dosed orally microcontainers dosage through drinking water. The selective effect on a resistant bacterial strain, as well effects fecal, luminal, and mucosal microbiota composition, were investigated. Three groups rats (
Animal models fed a high-fat high-sucrose (HFHS) diet are commonly used to study obesity and cardiometabolic diseases. While much attention is paid the impact of fat carbohydrates sources, very little consideration given composition dietary proteins. Indeed, casein often only source protein in rodent's diet. This aimed evaluate mix that more relevant typical intakes proteins humans its influences on body weight gain, metabolic health gut microbiota. Our new contained 10 sources based NHANES...
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