Mark A. McGuire

ORCID: 0000-0003-4329-0450
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About
Contact & Profiles
Research Areas
  • Infant Nutrition and Health
  • Fatty Acid Research and Health
  • Breastfeeding Practices and Influences
  • Gut microbiota and health
  • Ruminant Nutrition and Digestive Physiology
  • Milk Quality and Mastitis in Dairy Cows
  • Reproductive Physiology in Livestock
  • Lipid metabolism and biosynthesis
  • Probiotics and Fermented Foods
  • Genetic and phenotypic traits in livestock
  • COVID-19 Impact on Reproduction
  • Digestive system and related health
  • Birth, Development, and Health
  • Neonatal Respiratory Health Research
  • Nutritional Studies and Diet
  • Child Nutrition and Water Access
  • EFL/ESL Teaching and Learning
  • Pediatric health and respiratory diseases
  • Microbial infections and disease research
  • Diet, Metabolism, and Disease
  • Cancer, Lipids, and Metabolism
  • Second Language Learning and Teaching
  • Effects of Environmental Stressors on Livestock
  • SARS-CoV-2 and COVID-19 Research
  • Regulation of Appetite and Obesity

University of Idaho
2016-2025

The Ohio State University
2021-2024

Children's National
2021

The University of Sydney
2000-2020

Royal Prince Alfred Hospital
2000-2020

Prince of Wales Hospital
2020

National Hospital
2020

University of Otago
2005-2018

McMaster University
2015

Self Regional Healthcare
2015

Recent investigations have demonstrated that human milk contains a variety of bacterial genera; however, as yet very little work has been done to characterize the full diversity these communities and their relative stability over time. To more thoroughly investigate microbiome, we utilized microbial identification techniques based on pyrosequencing 16S ribosomal RNA gene. Specifically, characterized present in samples collected from 16 women at three time-points four weeks. Results indicated...

10.1371/journal.pone.0021313 article EN cc-by PLoS ONE 2011-06-17

We examined the role of trans-octadecenoic acids in milk fat depression when low fiber diets were fed. The study consisted four experimental periods with a 2 x factorial arrangement treatments to test effects dietary (saturated vs. unsaturated) and rumen fermentation (high diets) on depression. Dietary concentration type had significant fat. Effects most pronounced unsaturated was added diet. When diet plus fed, percentage yield decreased by 30 35%, respectively, compared high saturated...

10.3168/jds.s0022-0302(98)75686-3 article EN cc-by-nc-nd Journal of Dairy Science 1998-05-01

Abstract Fly larvae may provide an effective method to mitigate two large and growing global concerns: the use of fish meal derived from capture fisheries in aquaculture diets manure management livestock poultry facilities. A 9‐wk feed trial was conducted determine whether fly could be used as a partial oil replacement rainbow trout, Oncorhynchus mykiss , diets. trout diet formulated contain 40% crude protein 15% fat. Sixty‐seven percent control meal, all fat oil. Two test included using...

10.1111/j.1749-7345.2006.00073.x article EN Journal of the World Aquaculture Society 2007-03-01

Abstract.— The black soldier fly, Hermetia illucens , has the potential to reduce animal waste on livestock facilities and produce an animal‐grade feedstuff high in protein fat. lipid content of insects is largely dependent their diet. Data from this study suggest that fly prepupae incorporate α‐linolenic acid (ALA), eicosapentaenoic (EPA), docosahexaenoic (DHA) when fish offal included Fly larvae were fed three different proportions cow manure diets over a 21‐d trial. An additional group...

10.1111/j.1749-7345.2007.00101.x article EN Journal of the World Aquaculture Society 2007-05-25

Background: Human milk is a complex fluid comprised of myriad substances, with one the most abundant substances being group carbohydrates referred to as human oligosaccharides (HMOs). There has been some evidence that HMO profiles differ in populations, but few studies have rigorously explored this variability. Objectives: We tested hypothesis diverse populations healthy women. Next, we examined relations between and maternal anthropometric reproductive indexes indirectly whether differences...

10.3945/ajcn.116.139980 article EN cc-by American Journal of Clinical Nutrition 2017-03-30

A growth trial and fillet sensory analysis were conducted to examine the effects of replacing dietary fish meal with black soldier fly (BSF) prepupae, Hermetia illucens , in rainbow trout, Oncorhynchus mykiss . practical‐type trout diet was formulated contain 45% protein; four test diets developed by substituting 25 50% normal or offal‐enriched (EBSF) prepupae. Dietary fat adjusted approximately 20% lipid using oil poultry fat. Diets fed three replicate tanks per treatment (10 fish/tank) for...

10.1111/j.1749-7345.2010.00441.x article EN Journal of the World Aquaculture Society 2011-02-01

Background Microbial communities in human milk and those feces from breastfed infants vary within across populations. However, few researchers have conducted cross-cultural comparisons between populations, little is known about whether certain "core" taxa occur normally or populations variation microbiome related to infant fecal microbiome. The purpose of this study was describe microbiomes produced by relatively healthy women living at diverse international sites compare these the their...

10.3389/fnut.2019.00045 article EN cc-by Frontiers in Nutrition 2019-04-17

Conjugated linoleic acids (CLA) may influence the onset and severity of several chronic diseases, including various cancers, atherosclerosis, obesity, bone density loss, diabetes. These findings are special interest to agriculture community, because dietary sources CLA almost exclusively beef dairy products. Thus, a better understanding specific isomers mechanisms responsible for these positive effects on human health would be both prudent economically beneficial. To date, research related...

10.2527/jas2000.00218812007700es0033x article EN Journal of Animal Science 2000-01-01

The human milk microbiome has been somewhat characterized, but little is known about changes over time and relations with maternal factors such as nutrient intake. We sought to characterize the described associations intake, postpartum, delivery mode, body mass index (BMI; in kg/m2). Milk samples (n = 104) 24-h diet recalls were collected 9 times from 21 healthy lactating women day 2 6 mo postpartum. Women classified by BMI weight (<25) or overweight obese (≥25). Bacterial taxa characterized...

10.3945/jn.117.248864 article EN publisher-specific-oa Journal of Nutrition 2017-09-01

Neonatal gastrointestinal (GI) bacterial community structure may be related to communities of the mother, including those her milk. However, very little is known about diversity in and relationships among complex mother-infant dyads.

10.1093/jn/nxy299 article EN cc-by Journal of Nutrition 2018-11-12

Human milk provides a very wide range of nutrients and bioactive components, including immune factors, human oligosaccharides, commensal microbiota. These factors are essential for interconnected processes immunity programming the development normal infant gastrointestinal microbiome. Newborn protection mostly relies on maternal provided through milk. However, studies dealing with an in-depth profiling different compounds present in assessment their natural variation healthy women from...

10.3389/fimmu.2017.00696 article EN cc-by Frontiers in Immunology 2017-06-30

Abstract Background It is not known whether SARS-CoV-2 can be transmitted from mother to infant during breastfeeding, and if so the benefits of breastfeeding outweigh this risk. This study was designed evaluate 1) RNA detected in milk on breast infected women, 2) concentrations milk-borne anti-SARS-CoV-2 antibodies, 3) capacity neutralize infectivity. Methods We collected 37 samples 70 swabs (before after washing) 18 women recently diagnosed with COVID-19. Samples were analyzed for using...

10.1101/2020.09.16.20196071 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2020-09-18

The novel coronavirus SARS-CoV-2 has emerged as one of the most compelling public health challenges our time. To address myriad issues generated by this pandemic, an interdisciplinary breadth research, clinical, and communities have rapidly engaged to find answers solutions. One area active inquiry is understanding mode(s) transmission. While respiratory droplets are a known mechanism transmission, other mechanisms possible. Of particular importance global possibility vertical transmission...

10.1101/2020.04.07.20056812 preprint EN cc-by medRxiv (Cold Spring Harbor Laboratory) 2020-04-11

The goal of Working Group 1 in the Breastmilk Ecology: Genesis Infant Nutrition (BEGIN) Project was to outline factors influencing biological processes governing human milk secretion and evaluate our current knowledge these processes. Many regulate mammary gland development utero, during puberty, pregnancy, through secretory activation, at weaning. These include breast anatomy, vasculature, diet, lactating parent's hormonal milieu including estrogen, progesterone, placental lactogen,...

10.1016/j.ajcnut.2022.11.026 article EN cc-by American Journal of Clinical Nutrition 2023-05-01

Generating top-down tandem mass spectra (MS/MS) from complex mixtures of proteoforms benefits improvements in fractionation, separation, fragmentation, and analysis. The algorithms to match MS/MS sequences have undergone a parallel evolution, with both spectral alignment match-counting approaches producing high-quality proteoform-spectrum matches (PrSMs). This study assesses state-of-the-art for identification (ProSight PD, TopPIC, MSPathFinderT, pTop) their yield PrSMs while controlling...

10.1021/acs.jproteome.2c00673 article EN cc-by-nc-nd Journal of Proteome Research 2023-05-26
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