A5060428161- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Neural dynamics and brain function
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Cell Image Analysis Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Amino Acid Enzymes and Metabolism
- Advanced Memory and Neural Computing
- Advanced Fluorescence Microscopy Techniques
- Memory and Neural Mechanisms
University at Albany, State University of New York
2017-2023
State University of New York
2019
Cornell University
2011
Most animal species operate according to a 24-h period set by the suprachiasmatic nucleus (SCN) of hypothalamus. The rhythmic activity SCN modulates hippocampal-dependent memory, but molecular and cellular mechanisms that account for this effect remain largely unknown. Here, we identify cell-type-specific structural functional changes occur with circadian rhythmicity in neurons astrocytes hippocampal area CA1. Pyramidal change surface expression NMDA receptors. Astrocytes their proximity...
Abstract Interference is a critical problem for memory systems and primary cause of retrieval failure. One strategy minimizing interference to associate the items be remembered with context in which they were learned. For example, human subjects who learn two lists words separate contexts experience less better recall than both same context. The hippocampus has long been known involved processing contextual information recent studies have shown that hippocampal neurons exhibit context‐unique...
There is an ongoing debate on the contribution of neuronal glutamate transporter EAAC1 to onset compulsive behaviors. Here, we used behavioral, electrophysiological, molecular, and viral approaches in male female mice identify molecular cellular mechanisms by which controls execution repeated motor Our findings show that, striatum, a brain region implicated with movement execution, limits group I metabotropic receptor (mGluRI) activation, facilitates D1 dopamine (D1R) expression, ensures...
Group III metabotropic glutamate receptors (mGluRIII) are expressed broadly throughout the neocortex and hippocampus but thought to inhibit neurotransmitter release only at a subset of synapses in target cell- specific manner. Accordingly, previous slice physiology experiments hippocampal area CA1 showed that mGluRIII GABA excitatory inhibitory formed onto GABAergic interneurons, not pyramidal cells. Here, we show supposed cell-specific modulation occurs when extracellular calcium...
Synapses are critical targets of Alzheimer s disease (AD), a highly prevalent neurodegenerative associated with accumulation extracellular amyloid-β peptides. Although amyloidosis and aggregation the 42-amino acid (Aβ42) have long been considered pathogenic triggers for AD, clinical evidence linking high levels Aβ42 normal cognition challenges this hypothesis. To resolve conundrum on role in regulating synaptic activity, we used an adeno-associated viral vector approach that spatial memory...
Understanding the function of glutamate transporters has broad implications for explaining how neurons integrate information and relay it through complex neuronal circuits. Most what is currently known about transporters, specifically their ability to maintain homeostasis limit diffusion away from synaptic cleft, based on studies glial transporters. By contrast, little functional The transporter EAAC1 widely expressed throughout brain, particularly in striatum, primary input nucleus basal...
Summary Most animal species operate according to a 24-hour period set by the suprachiasmatic nucleus (SCN) of hypothalamus. The rhythmic activity SCN is known modulate hippocampal-dependent memory processes, but molecular and cellular mechanisms that account for this effect remain largely unknown. Here, we show there are cell-type specific structural functional changes occur with circadian rhythmicity in neurons astrocytes hippocampal area CA1. Pyramidal change surface expression NMDA...
Abstract One of the fundamental goals in neuroscience is to determine how brain processes information and ultimately controls execution complex behaviors. Over past four decades, there has been a steady growth our knowledge morphological functional diversity neurons, building blocks brain. These cells clearly differ not only for their anatomy ion channel distribution, but also type, strength, location, temporal pattern activity many synaptic inputs they receive. Compartmental modeling...
ABSTRACT There is an ongoing debate on the contribution of neuronal glutamate transporter EAAC1 to onset compulsive behaviors. Here we use behavioral, electrophysiological, molecular and viral approaches in male female mice identify cellular mechanisms by which controls execution repeated motor Our findings show that striatum, a brain region implicated with movement execution, limits group I metabotropic receptor (mGluRI) activation, facilitates D1 dopamine (D1R) expression ensures long-term...
Most animal species operate according to a 24-hour period set by the suprachiasmatic nucleus (SCN) of hypothalamus. The rhythmic activity SCN is known modulate hippocampal-dependent memory processes, but molecular and cellular mechanisms that account for these effects remain largely unknown. Here, we show there are cell-type specific structural functional changes occur with circadian rhythmicity in neurons astrocytes hippocampal area CA1. Pyramidal change surface expression NMDA receptors,...
Abstract Understanding the function of glutamate transporters has broad implications for explaining how neurons integrate information and relay it through complex neuronal circuits. Most what is currently known about transporters, specifically their ability to maintain homeostasis limit diffusion away from synaptic cleft, based on studies glial transporters. By contrast, little functional The transporter EAAC1 widely expressed throughout brain, particularly in striatum, primary input nucleus...
Abstract One of the fundamental goals in neuroscience is to determine how brain processes information and ultimately controls execution complex behaviors. Over past four decades, there has been a steady growth our knowledge morphological functional diversity neurons, building blocks brain. These cells clearly differ not only for their anatomy ion channel distribution, but also type, strength, location temporal pattern activity many synaptic inputs they receive. Compartmental modeling...