A5024033077- Curcumin's Biomedical Applications
- Mesenchymal stem cell research
- Antioxidant Activity and Oxidative Stress
- Phytochemicals and Antioxidant Activities
- Natural Antidiabetic Agents Studies
- SARS-CoV-2 and COVID-19 Research
- Protein Hydrolysis and Bioactive Peptides
- Adipokines, Inflammation, and Metabolic Diseases
- Extracellular vesicles in disease
- Biochemical effects in animals
- Complement system in diseases
- Adipose Tissue and Metabolism
- Pineapple and bromelain studies
- SARS-CoV-2 detection and testing
- Sphingolipid Metabolism and Signaling
- Radiation Therapy and Dosimetry
- Neuroinflammation and Neurodegeneration Mechanisms
- Ethnobotanical and Medicinal Plants Studies
- Garlic and Onion Studies
- Renal Diseases and Glomerulopathies
- RNA Interference and Gene Delivery
- Biomarkers in Disease Mechanisms
- Essential Oils and Antimicrobial Activity
- GABA and Rice Research
- Diet and metabolism studies
Centre Hospitalier Universitaire de La Réunion
2020-2024
Centre de Coopération Internationale en Recherche Agronomique pour le Développement
2024
Université de Montpellier
2024
Institut de Recherche pour le Développement
2024
Institut Agro Montpellier
2024
Pharmac
2021
Observatoire des Sciences de l'Univers de la Réunion
2012-2020
Inserm
2016
Écologie Marine Tropicale des Océans Pacifique et Indien
2016
University of Reunion Island
2014
<h2>Abstract</h2> In radiotherapy, metallic nanoparticles are of high interest in the fight against cancer for their radiosensitizing effects. This study aimed to evaluate ability core-shell Fe<sub>3</sub>O<sub>4</sub>@Au potentiate irradiation effects on redox-, pro-inflammatory markers, and cell death A549 human pulmonary cells. The hybrid were synthesized using green chemistry principles by sonochemistry method. Their characterization transmission electron microscopy demonstrated an...
Obesity has been associated with a marked risk of metabolic diseases and requires therapeutic strategies. Changes in redox status increased oxidative stress adipose tissue have linked obesity-related disorders. Thus, the biological effect antioxidants such as polyphenols is high interest. We aimed to measure antioxidant capacities 28 representative main dietary phenolic acids, flavonoids, stilbenes curcuminoids. Then, 14 molecules were selected for evaluation their on 3T3-L1 preadipocytes...
The complement (C) innate immune system has been shown to be activated in the tumor microenvironment of various cancers. C may support growth by modulating response and promoting angiogenesis through actions anaphylatoxins (e.g., C5a, C3a). important double-edged sword functions brain, but little is known about its role brain tumors. Hence, we analyzed distribution regulated expression C3a receptor C3aR primary secondary We found that was dramatically upregulated Grade 4 diffuse gliomas,...
Plant polyphenols may exert beneficial action against obesity-related oxidative stress and inflammation which promote insulin resistance. This study evaluated the effect of extracted from French Curcuma longa on 3T3-L1 adipose cells exposed to H2 O2 -mediated stress. We found that extract exhibited high amounts curcuminoids identified as curcumin, demethoxycurcumin, bisdemethoxycurcumin, exerted free radical-scavenging activities. improved insulin-mediated lipid accumulation upregulated...
Abstract O’nyong-nyong virus is an alphavirus closely related to chikungunya virus, causing arthralgia, rash and fever. Alphaviruses mainly target synovial fibroblasts persists in the joints of patients, possibly leading chronic arthritis. To date, no specific antiviral treatment available for ONNV infection induced-inflammation. Primary human cells were used assess by resulting cytokine responses. Phenolics (gallic acid, caffeic acid chlorogenic curcumin quercetin) a curcuminoids-rich...
Patients following infection by chikungunya virus (CHIKV) can suffer for months to years from arthralgia and arthritis. Interestingly, methotrexate (MTX) a major immune-regulatory drug has proved be of clinical benefit. We have previously shown that CHIKV persist in the joint one patient 18 post-infection plausibly driving chronic inflammation but through ill-characterized mechanisms. pursued our investigations report novel histological vitro data arguing plausible role COX-2-mediated...
The complement system plays a crucial role in cancer development. Our study investigated the of C3a anaphylatoxin on tumor microenvironment. models consisted mesenchymal stem cells (MSC-like, 3T3-L1), macrophages (Raw 264.7 Blue, (RB)) and (melanoma B16/F0). Recombinant mouse (Mo) (rC3a) was produced CHO transfected with Mo-IL10-signal peptide-Mo plasmid construct. effects rC3a, IFN-γ, TGF-β1, LPS were tested expression C3, C3aR, PI3K, cytokines, chemokines, transcription factors,...
Humoral immunity is critically important to control COVID-19. Long-term antibody responses remain be fully characterized in hospitalized patients who have a high risk of death. We compared specific Immunoglobulin against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) between two groups, intensive care unit (ICU) and non-ICU over several weeks. Plasma IgG, IgM, IgA levels were assessed using commercial ELISA an in-house cell-based ELISA. Among the analyzed (mean (SD) age, 64.4...
Fibrosis is a chronic progressive and incurable disease leading to organ dysfunction. It characterized by the accumulation of extracellular matrix proteins produced mesenchymal stem cells (MSCs) differentiating into myofibroblasts. Given complexity its pathophysiology, search for effective treatments fibrosis paramount importance. Metformin, structural dimethyl analog galegine guanide extracted from “French Lilac” (Fabaceae Galega officinalis), most widely used antidiabetic drug, recently...
Infection by arthritogenic alphaviruses (aavs) can lead to reactive arthritis, which is characterized inflammation and persistence of the virus; however, its mechanisms remain ill-characterized. Intriguingly, it has been shown that viral still takes place in spite robust innate adaptive immune responses, notably infiltration macrophages (sources TNF-alpha) as well T/NK cells IFN-gamma) infected joint. Aavs are known target mesenchymal stem (MSCs) synovium, we herein tested hypothesis...
Manihot esculenta (cassava) roots is a major food crop for its energy content. Leaves contain nutrients and demonstrate biological properties but remain undervalorized. In order to develop bioguided optimization of cassava nutrition–health properties, we compared the phytochemistry bioactive potential root flour extract (CF) with enriched 30% leaves powder (CFL). Cassava supplementation impact was explored on composition (starch, fiber, carotenoids, phenolic compounds), in vivo glycemic...
Background/Objectives: Metallic nanoparticles (NPs) exhibit interesting radiosensitizing effects, and finding a way to accurately deliver them appears be crucial. Due their tumor tropism, mesenchymal stem cells (MSCs) represent strategic approach. Therefore, we aimed evaluate the impact of core–shell Fe3O4@Au NPs on functionality human pulmonary MSCs (HPMSCs). Methods/Results: The results showed that 100 µg/mL NPs, accumulated in HPMSCs (revealed by Prussian blue staining), did not alter...